925 completed, 263 unknown, 130 recruiting, 72 not yet recruiting. 385 Not applicable, 276 Phase 2, 201 Phase 1, 166 Phase 3, 100 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Advanced HIV Re-engagement in Care ARC - Advanced HIV Disease | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 724 | 2027-05-01 | 2026-07-23 |
| Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB ID93 + GLA-SE vaccine, Placebo vaccine - Tuberculosis, Pulmonary | Phase 2 | Not yet recruiting | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 1500 | 2027-01-31 | 2026-08-24 |
| Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa VPM1002 Vaccine, BCG Vaccine, Placebo - Tuberculosis, HIV Infections | Phase 1 / Phase 2 | Withdrawn | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 2026-12-31 | 2026-08-17 | |
| Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities Tuberculosis, Tuberculosis (TB) | Not yet recruiting | Universidade Nova de Lisboa | 200 | 2026-12-01 | 2026-07-07 | |
| Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children Cryopreserved aorta - Trachea Diseases, Tracheal Stenosis | Not applicable | Enrolling by invitation | National Taiwan University Hospital | 5 | 2026-12-01 | 2026-08-17 |
| A Clinical Study of the HCMV-TB Vaccine Candidate VIR-1778 in Healthy Adults VIR-1778 (5 × 10^5 ffu), VIR-1778 (5 × 10^6 ffu), HT Diluent Placebo - Tuberculosis | Phase 1 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 116 | 2026-11-06 | 2026-09-14 |
| The LalelaLung Study: Digital Stethoscope Clinical Evaluation StethoMe AI-enabled digital stethoscope system, Standard IMCI assessment - Pneumonia, Tuberculosis, Pulmonary | Phase 4 | Not yet recruiting | Johns Hopkins University | 350 | 2026-11-02 | 2026-09-23 |
| A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB) Isoniazid, Rifampin, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 900 | 2026-10-30 | 2026-08-19 |
| Integrating Tuberculosis Treatment Into Community Pharmacies to Improve TB/HIV Outcomes in Uganda The intervention is TB treatment delivery via community pharmacies for people with TB/HIV, Control Arm - standard of care - TB - Tuberculosis, HIV - Human Immunodeficiency Virus | Not applicable | Not yet recruiting | Makerere University | 124 | 2026-10-01 | 2026-09-25 |
| Re-evaluating the Duration in Children of TB Treatment Rifampicin, Isoniazid, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 230 | 2026-10-01 | 2026-09-29 |
| Digital Psychosocial Interventions on Stigma and Health Outcomes in TB Patients Online Mindfulness, Online CBT Intervention, Human-computer Interaction - Tuberculosis (TB) | Not applicable | Not yet recruiting | Peking Union Medical College | 496 | 2026-10-01 | 2026-08-03 |
| A 6-Month MDR-END Plus Regimen for Rifampicin-Resistant Tuberculosis MDR-END Plus regimen, Standard-of-care (SoC) treatment - Rifampicin-Resistant Tuberculosis | Phase 3 | Not yet recruiting | Seoul National University Hospital | 294 | 2026-10-01 | 2026-06-30 |
| STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis Hydrocortisone administration, Expanded antimicrobial therapy - Sepsis, Tuberculosis | Phase 3 | Not yet recruiting | University of Virginia | 344 | 2026-10-01 | 2026-06-01 |
| Plasma MTB cfDNA Before Bronchoscopy Diagnostic Test: Plasma MTB cfDNA assay - Tuberculosis Diagnosis | Not yet recruiting | Chinese University of Hong Kong | 600 | 2026-10-01 | 2025-11-17 | |
| Silymarin Versus N-Acetylcysteine as Protective Effect Against Anti-tuberculosis Drugs Induced Liver Injury. Antituberculosis drugs Group - Drug-Induced Acute Liver Injury, Tuberculosis (TB) | Early Phase 1 | Not yet recruiting | Assiut University | 102 | 2026-10-01 | 2026-10-21 |
| Fibroblast Activating Protein (FAP) PET/CT in Adults With Tuberculosis [18F]-FAPI-74 - Tuberculosis, Pulmonary | Early Phase 1 | Recruiting | University of Pennsylvania | 10 | 2026-09-30 | 2026-09-21 |
| A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV Rifapentine, Isoniazid, Dolutegravir - Tuberculosis | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 144 | 2026-09-28 | 2026-10-19 |
| Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis TBAJ-587 50 mg, Pretomanid 200mg, Linezolid 600Mg Tab - Tuberculosis, Pulmonary | Phase 2 | Not yet recruiting | TASK Applied Science | 135 | 2026-09-25 | 2026-09-25 |
| Effectiveness of Chat-based Mobile Application for Consultation (Zalo) in Improving Compliance With Follow-up Tests After Abnormal Chest X-ray Findings Interpret by Artificial Intelligent chat-based mobile application (Zalo) - Lung Cancer, Tuberculosis (TB) | Not applicable | Recruiting | Gia Dinh People Hospital | 2692 | 2026-09-15 | 2026-09-16 |
| rBCG-N-RSV Vaccine in Adults Aged 60 Years and Older Vaccination with rBCG-N-RSV, Vaccination with conventional BCG (BCG-WT) - Respiratory Syncytial Virus Infection Prevention, Tuberculosis Prevention | Phase 2 | Recruiting | Biothervax SpA | 200 | 2026-09-14 | 2026-09-15 |
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Tuberculosis, Pulmonary (309) · Latent Tuberculosis (198) · Tuberculosis, Multidrug-Resistant (129) · HIV Infections (116) · Acquired Immunodeficiency Syndrome (92) · Disease (35) · Tuberculosis, Meningeal (30) · Mycobacterium Infections (26) · Lung Neoplasms (25) · Extensively Drug-Resistant Tuberculosis (23) · Pulmonary Disease, Chronic Obstructive (23) · Diabetes Mellitus (17) · Lung Diseases (17) · Pneumonia (16)
Bacterial Infections and Mycoses (1532) · Actinomycetales Infections (1531) · Gram-Positive Bacterial Infections (1529) · Bacterial Infections (1521) · Infections (1518) · Mycobacterium Infections (1506) · Respiratory Tract Diseases (399) · Lung Diseases (359) · Respiratory Tract Infections (345) · Immune System Diseases (225) · Virus Diseases (212) · Urogenital Diseases (207) · RNA Virus Infections (205) · Blood-Borne Infections (197)
Isoniazid (166) · Rifampin (130) · Pyrazinamide (92) · Ethambutol (70) · bedaquiline (64) · Moxifloxacin (54) · rifapentine (52) · Linezolid (44) · pretomanid (38) · OPC-67683 (34) · Levofloxacin (25) · MVA 85A (25) · efavirenz (22) · Clofazimine (20) · Rifabutin (20)
National Institute of Allergy and Infectious Diseases (NIAID) (84) · University of Oxford (38) · Johns Hopkins University (36) · Global Alliance for TB Drug Development (31) · Centers for Disease Control and Prevention (28) · University of Cape Town (28) · Aeras (23) · National Taiwan University Hospital (23) · Beijing Chest Hospital (19) · GlaxoSmithKline (19) · Assistance Publique - Hôpitaux de Paris (18) · Huashan Hospital (18) · Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. (17) · Seoul National University Hospital (16) · University of California, San Francisco (16)
South Africa (279) · United States (156) · China (107) · Uganda (107) · India (90) · United Kingdom (71) · South Korea (62) · Tanzania (59) · Brazil (58) · Indonesia (52) · Zambia (45) · Taiwan (43) · Thailand (42) · Vietnam (42) · France (41)
Helen McShane (20) · Nicholas Paton (10) · Clifton E Barry, Ph.D. (8) · Susan Dorman, MD (8) · Jae-Joon Yim, MD (7) · Andreas Diacon, MD (6) · Grant Theron, PhD (6) · Marc Weiner, MD (6) · Chin-Chung Shu, MD (5) · Dick Menzies, MD (5) · Richard Chaisson, MD (5) · Rodney Dawson, MD (5) · Sophia B Siddiqui, M.D. (5)
PMID 33616229, PMID 40122135, PMID 25466778, PMID 36808186, PMID 28043488, PMID 28063795, PMID 33542052, PMID 17957238, PMID 19529780, PMID 19880906, PMID 20442432, PMID 20629533, PMID 21215445, PMID 22150035, PMID 23691171, PMID 23979737, PMID 24675585, PMID 25114140, PMID 25359354, PMID 25904367, PMID 26400476, PMID 26647431, PMID 27243774, PMID 27868466, PMID 28216183, PMID 29393655, PMID 31866327, PMID 32539440, PMID 32785709, PMID 32934758, PMID 33283229, PMID 34021314, PMID 35404075, PMID 36053506, PMID 36546625, PMID 36560565, PMID 36730240, PMID 36949623, PMID 37035978, PMID 37980911, PMID 37988391, PMID 38768617, PMID 39189858, PMID 39252005, PMID 39651910, PMID 39752894, PMID 40067046, PMID 42054680, PMID 42286358, PMID 10767258
R01HD071779 (6), 2009 (5), U01AI068636 (4), UM1AI068636 (4), 2005 (3), 2017 (3), 2023 (3), 5UL1RR024982-02 (3), U01AI152087 (3), 2008 (2), 2014 (2), 2019 (2), D43TW009127 (2), R01AI150432 (2), R24TW007988 (2)