16 completed, 6 unknown, 5 not yet recruiting, 1 withdrawn. 21 Not applicable, 2 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Completed 13, Unknown 5, Not yet recruiting 3 |
| Phase 2 | 2 | Not yet recruiting 2 |
| Phase 3 | 2 | Not yet recruiting 2 |
| Phase 4 | 1 | Unknown 1 |
Follow TMJ Disc Disorder: new trials by email Literature Review of TMJ Disc Disorder trials Research Report on TMJ Disc Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ Arthroscopic lysis and lavage, arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid - TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction | Not applicable | Not yet recruiting | Cairo University | 52 | 2026-05-01 | 2026-05-29 |
| a Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Tomporomandibular Joint dextrose 5%, Arthrocentesis/Saline - TMJ Disc Disorder | Not applicable | Not yet recruiting | Cairo University | 42 | 2025-10-01 | 2025-08-19 |
| Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam Application of a rubber dam during dental treatments for varying durations. - Temporomandibular Joint Condition Post Longstanding Mouth Opening During Dental Procedure Using Rubber Dam, TMJ Disc Disorder | Not applicable | Not yet recruiting | Al-Azhar University | 300 | 2025-08-10 | 2025-02-18 |
| Therapeutic Effect of Microfragmented Adipose Tissue (Lipogems) Injection on Maximum Interincisal Opening Versus Injectable Platelet-rich Plasma (PRP) for the Treatment of Anterior Disc Displacement With Reduction : A Randomized Clinical Trial microfragmented adipose tissue, platelet-rich plasma - TMJ Disc Disorder | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 16 | 2025-08-05 | 2025-08-06 |
| Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial . injection of dextrose 10% in retrodiscal tissues, injection of dextrose 25% in retrodiscal tissues - TMJ Disc Disorder | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 24 | 2025-03-03 | 2025-03-05 |
| Comparison Between Different Concentrations of Ozone Gas as an Intra-articular Injection for Treatment of Internal Derangement of Tempromandibular Joint Patients will be treated with 2ml ozone oxygen mixture with concentration 6 micron/ml, Patients will be treated with 2ml ozone oxygen mixture with concentration 12 micron/ml - TMJ Disc Disorder | Not applicable | Completed | Alexandria University | 20 | 2025-02-01 | 2026-06-25 |
| Evaluation of the Effectiveness of Arthrocentesis Using Catheter in the Treatment of Temporamandibular Joint Disorders Procedure: TMJ Arthrocentesis - TMJ Disc Disorder, Treatment | Not applicable | Completed | Eskisehir Osmangazi University | 30 | 2025-01-13 | 2026-10-16 |
| i-PRF for Temporomandibular Joint Disorders Arthrocentesis (lavage only), Arthrocentesis + Injectable Platelet-Rich Fibrin (i-PRF) - TMJ Disc Disorder, Treatment | Not applicable | Completed | Eskisehir Osmangazi University | 40 | 2024-09-02 | 2025-09-23 |
| Arthrocentesis of Temporomandibular Joint Using Ozonated Water Alongside With Platelet Rich Plasma Injection in Management of Anterior Disc Displacement Without Reduction: Ozonated water and PRP injection, Ozonated water - TMJ Disc Disorder | Not applicable | Completed | Alexandria University | 20 | 2024-07-02 | 2026-09-25 |
| Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials intra-articular injection with Platelet lysate (PL)., intra-articular injection with Hyaluronic Acid. - TMJ Disc Disorder | Not applicable | Completed | Mansoura University | 60 | 2024-04-01 | 2024-12-04 |
| I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin And Botulinum Toxin Type A, TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin, TMJ Arthrocentesis - TMJ Disc Disorder, TMJ Pain | Not applicable | Completed | Fayoum University | 39 | 2024-01-18 | 2026-09-01 |
| Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic for Internal Derangement Chitosan-Hyaluronate Gel Mixture, Hyaluronic Acid - TMJ Disc Disorder | Phase 4 | Unknown | Ain Shams University | 20 | 2024-01-17 | 2024-05-23 |
| Evaluation of Arthrocentesis With and Without PRP Injection in Patients With Disc Displacement With Reduction. arthrocentesis without PRP, arthrocentesis with PRP - TMJ Disc Disorder | Not applicable | Completed | Cairo University | 74 | 2023-08-01 | 2024-08-27 |
| Ultrasound-Guided Vs Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. a Randomized Clinical Trial Prolotherapy - TMJ Disc Disorder, Ultrasound Therapy; Complications | Not applicable | Completed | Cairo University | 22 | 2022-11-10 | 2024-09-19 |
| Assessment of Concentric Needle Technique in Temporomandibular Joint (TMJ) Internal Derangement. Arthrocentesis - TMJ Disc Disorder | Not applicable | Unknown | Cairo University | 20 | 2022-09-01 | 2022-08-22 |
| Comparing Single Needle and Double Needle Arthrocentesis for Temporomandibular Joint Disorders Singel Needle Double Cannula TMJ Arthrocentesis, Double Needle TMJ Arthrocentesis - TMJ Disc Disorder | Not applicable | Completed | Yuzuncu Yil University | 28 | 2022-01-01 | 2025-01-03 |
| MDR-JuggerKnot Mini Soft Anchor in Maxillofacial TMJ JuggerKnot Mini Soft Anchor - TMJ Disc Disorder, TMJ Pain | Withdrawn | Zimmer Biomet | 2021-12-01 | 2022-01-27 | ||
| A Comparative Study Between the Different Levels of TMJ Arthroscopy in the Management of TMJ Internal Derangement three levels of TMJ arthroscopy - TMJ Disc Disorder | Not applicable | Completed | Alexandria University | 30 | 2021-06-01 | 2023-10-10 |
| Comparison Between Splint and Laser in Patients Without Disc Displacement With Reduction stabilization splint, laser therapy, stabilization splint and laser therapy - TMJ Disc Disorder | Not applicable | Completed | Mansoura University | 42 | 2021-03-03 | 2022-09-27 |
| Clinical and MRI Finding of The Temporomandibular Joint Posterior Disk Displacement MRI - TMJ Disc Disorder | Completed | Al-Azhar University | 900 | 2020-02-20 | 2021-07-07 |
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Temporomandibular Joint Disorders (5) · Chronic Pain (1) · Facial Pain (1) · Myofascial Pain Syndromes (1) · Osteoarthritis (1) · Tinnitus (1)
Musculoskeletal Diseases (7) · Joint Diseases (6) · Muscular Diseases (6) · Craniomandibular Disorders (5) · Jaw Diseases (5) · Mandibular Diseases (5) · Stomatognathic Diseases (5) · Neurologic Manifestations (2) · Pain (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Arthritis (1) · Ear Diseases (1) · Hearing Disorders (1) · Nervous System Diseases (1)
Arthrocentesis (6) · Hyaluronic Acid (2) · Arthroscopy (1) · Botulinum Toxins, Type A (1) · Control Groups (1) · Injections, Intra-Articular (1) · Laser Therapy (1) · Low-Level Light Therapy (1) · Prolotherapy (1) · Sodium Chloride (1) · Therapeutic Irrigation (1) · proliferation regulatory factors, human urine (1)
Cairo University (10) · Al-Azhar University (5) · Alexandria University (3) · Eskisehir Osmangazi University (2) · Mansoura University (2) · Ain Shams University (1) · Fayoum University (1) · Fonseca, Julio (1) · Istanbul Arel University (1) · Yuzuncu Yil University (1) · Zimmer Biomet (1)
Egypt (15) · Turkey (Türkiye) (4) · Portugal (1)
Nadia Galal, MD (2) · Ayman Hegab, Phd (1) · Kacy Arnold (1) · Mohamed Fayad, MD (1) · Moustafa Mohamed Talaat, Cairo assistant professor, PHD (1) · Nadia Galal, Ass.prof (1) · Noha Elshahid (1) · Ozge Baykan Copuroglu, MSc (1) · Yasmine AA Nassar (1)
PMID 22855899, PMID 28618972, PMID 29244893, PMID 35501215, PMID 36564950, PMID 38840358, PMID 39482101, PMID 39957867, PMID 42049640, PMID 42062696