13 completed, 2 not yet recruiting, 2 terminated, 2 unknown. 20 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 13, Not yet recruiting 2, Terminated 2, Unknown 2, Withdrawn 1 |
| Phase 2 | 9 | Completed 7, Not yet recruiting 2 |
Follow Tinnitus: new trials by email Literature Review of Tinnitus trials Research Report on Tinnitus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Testing Safety and Efficacy of Transtympanic Paliroden for the Treatment of Cochlear Synaptopathy in Participants With Chronic, Constant Tinnitus paliroden (CIL001), Placebo - Tinnitus, Bilateral, Cochlear Synaptopathy | Phase 1 / Phase 2 | Not yet recruiting | Cilcare SAS | 60 | 2027-01-01 | 2026-09-17 |
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | San Diego State University | 20 | 2026-11-01 | 2026-11-06 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Blinding and Adverse Effects of Ultrasonic Vagus Nerve Stimulation (U-VNS) Ultrasound Vagus Nerve Stimulation (U-VNS), Sham U-VNS - U-VNS, Sham U-VNS | Phase 1 / Phase 2 | Completed | University of Nottingham | 20 | 2024-12-10 | 2025-07-29 |
| Treatment of Tinnitus With Olanzapine Olanzapine 5 Mg ORAL TABLET, Placebo Drug - Tinnitus, Tinnitus, Subjective | Phase 1 | Completed | University of Sao Paulo | 50 | 2023-10-01 | 2026-09-15 |
| OTO-313 in Subjects With Subjective Tinnitus OTO-313, Placebo - Tinnitus, Subjective | Phase 1 / Phase 2 | Completed | Otonomy, Inc. | 43 | 2019-04-04 | 2022-12-23 |
| Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis Venous stenting for internal jugular vein stenosis, One-month routine medical treatment followed by venous stenting for internal jugular vein stenosis - Stent Stenosis, Intracranial Hypertension | Phase 1 | Unknown | Capital Medical University | 60 | 2018-01-01 | 2017-12-14 |
| Study to Evaluate SPI-1005 in Adults With Meniere's Disease SPI-1005 - Meniere's Disease | Phase 1 / Phase 2 | Completed | Sound Pharmaceuticals, Incorporated | 40 | 2015-12-01 | 2026-06-29 |
| Evaluation of Adding Lidocaine to Dexamethasone in Intra-tympanic Injection for Management of Tinnitus Intra-tympanic injection of drugs, Data management of intratympanic drugs - Tinnitus | Phase 1 | Completed | saad elzayat | 44 | 2015-03-01 | 2017-08-29 |
| Pilot Study of Deep Brain Stimulation (DBS) in Area LC for Chronic Tinnitus Deep Brain Stimulation (DBS) - Tinnitus | Phase 1 | Completed | Paul Larson | 10 | 2014-01-01 | 2019-04-18 |
| Effectiveness of Cannabis in the Treatment of Tinnitus Patients Cannabis, Placebo - Tinnitus | Phase 1 | Withdrawn | Wolfson Medical Center | 2013-12-01 | 2016-12-28 | |
| Gameplay as a Source of Intrinsic Motivation in a Randomized Controlled Trial of Auditory Training for Tinnitus reactive auditory training, Interactive auditory training - Tinnitus | Phase 1 / Phase 2 | Completed | Nottingham University Hospitals NHS Trust | 60 | 2011-08-01 | 2016-11-04 |
| Transcranial Magnetic Stimulation for Tinnitus repetitive transcranial magnetic stimulation (rTMS), placebo rTMS - Tinnitus | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 70 | 2011-03-01 | 2017-03-29 |
| Hearing Impairment, Cognitive Therapy and Coping 8-session CBTcourse, 8 session cognitive behavioral therapy - Hearing Loss, Tinnitus | Phase 1 | Unknown | Oslo University Hospital | 180 | 2010-10-01 | 2013-06-14 |
| OTO-104 for Meniere's Disease OTO-104 (steroid) 3 mg, Placebo, OTO-104 (steroid) 12 mg - Meniere's Disease | Phase 1 | Completed | Otonomy, Inc. | 44 | 2010-03-01 | 2011-06-08 |
| Cognitive Behavioral Therapy (CBT) for Tinnitus Cognitive Behavioral Therapy, Tinnitus Education - Tinnitus | Phase 1 / Phase 2 | Completed | US Department of Veterans Affairs | 33 | 2009-02-01 | 2015-05-06 |
| Safety Study for NST-001 and the Neuroject Injection Set to Treat Tinnitus NST-001 - Tinnitus | Phase 1 | Terminated | NeuroSystec Corporation | 8 | 2009-01-01 | 2013-04-22 |
| Clinical Trial of Acamprosate for Tinnitus Acamprosate, Placebo - Tinnitus | Phase 1 | Completed | Oregon Health and Science University | 154 | 2008-01-01 | 2016-11-08 |
| Use of Modafinil in the Treatment of Tinnitus Modafinil, Placebo - Tinnitus | Phase 1 | Terminated | University of Arkansas | 7 | 2006-08-01 | 2015-10-08 |
| The Effect of Tinnitus Retraining Therapy on Subjective and Objective Measures of Chronic Tinnitus Tinnitus retraining therapy, Sound therapy - Tinnitus | Phase 1 | Completed | Tinnitus Research Consortium | 41 | 2005-11-01 | 2009-09-24 |
Hearing Loss (3) · Meniere Disease (2) · Vertigo (2) · Escape Reaction (1) · Headache (1) · Hearing Loss, Hidden (1) · Intracranial Hypertension (1) · Mental Fatigue (1) · Papilledema (1) · Stress, Psychological (1) · Vision Disorders (1)
Ear Diseases (20) · Hearing Disorders (20) · Nervous System Diseases (20) · Neurologic Manifestations (20) · Otorhinolaryngologic Diseases (20) · Pathological Conditions, Signs and Symptoms (20) · Sensation Disorders (20) · Signs and Symptoms (20) · Endolymphatic Hydrops (2) · Labyrinth Diseases (2) · Vestibular Diseases (2) · Behavior (1) · Behavior, Animal (1) · Behavioral Symptoms (1) · Brain Diseases (1)
Nicotine Chewing Gum (2) · Acamprosate (1) · Cognitive Behavioral Therapy (1) · Deep Brain Stimulation (1) · Lidocaine (1) · Modafinil (1) · Olanzapine (1) · Steroids (1) · Tablets (1) · Transcranial Magnetic Stimulation (1) · ebselen (1) · nabiximols (1)
Otonomy, Inc. (2) · San Diego State University (2) · Capital Medical University (1) · Cilcare SAS (1) · NeuroSystec Corporation (1) · Nottingham University Hospitals NHS Trust (1) · Oregon Health and Science University (1) · Oslo University Hospital (1) · Paul Larson (1) · Sound Pharmaceuticals, Incorporated (1) · Tinnitus Research Consortium (1) · US Department of Veterans Affairs (1) · University of Arkansas (1) · University of Nottingham (1) · University of Sao Paulo (1)
United States (11) · United Kingdom (2) · Belgium (1) · Brazil (1) · France (1) · Israel (1) · Norway (1)
Xianhui Wang (2) · Bruno Frachet, MD (1) · Carl LeBel, PhD (1) · Carol A Bauer, MD (1) · Deborah Hall, Professor (1) · Egil W Martinsen, Prof. dr. med. (1) · John L Dornhoffer, MD (1) · Jonathan Kil, MD (1) · Katharine C Williams, cand. psychol. (1) · Paul Larson, MD (1) · Pierre Garin, MD (1) · Ran Meng, MD, PhD (1) · Robert D. Kerns, PhD (1)
PMID 15474106, PMID 25215617, PMID 25470623, PMID 26181507, PMID 28183355, PMID 30738400, PMID 31553940, PMID 32483557, PMID 33281736