39 completed, 11 recruiting, 9 unknown, 7 active not recruiting. 18 Phase 2, 14 Not applicable, 8 Phase 1, 8 Phase 3, 6 Phase 4.
Follow Synovitis: new trials by email Literature Review of Synovitis trials Research Report on Synovitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| Transarterial Embolization Versus Sham Procedure in Adults With Treatment-Resistant Inflammatory Arthritis of a Single Large Joint Transarterial embolization with resorbable gelatin microspheres, Sham embolization procedure - Arthritis | Not applicable | Not yet recruiting | Istituto Ortopedico Rizzoli | 30 | 2026-11-01 | 2026-10-14 |
| A Study of DCC-3014 to Evaluate the Efficacy, Safety, and Pharmacokinetics in Subjects With TGCT DCC-3014 - Tenosynovial Giant Cell Tumor | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 18 | 2026-10-31 | 2026-09-22 |
| Synovial Tissue as a Biomarker in the Management of Pigmented Villonodular Synovitis synovial biopsy - Synovitis Villonodular | Not applicable | Recruiting | Nantes University Hospital | 30 | 2026-10-30 | 2026-11-06 |
| Musculoskeletal Ultrasound in Patients With Hematologic Malignancies Hematologic Neoplasms, Leukemia | Not yet recruiting | Assiut University | 50 | 2026-09-01 | 2026-08-25 | |
| Musculoskeletal Ultrasound for Differentiating Rheumatoid and Gouty Arthritis Rheumatoid Arthritis (RA), Gouty Arthritis (GA) | Not yet recruiting | Assiut University | 100 | 2026-07-01 | 2026-06-18 | |
| Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER) Pimicotinib - Tenosynovial Giant Cell Tumor | Phase 2 | Recruiting | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 20 | 2026-03-26 | 2026-10-23 |
| Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor Surgery Indocyanine Green - Tenosynovial Giant Cell Tumor | Phase 4 | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 40 | 2026-01-02 | 2026-01-05 |
| MOVE: Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib Tenosynovial Giant Cell Tumor | Recruiting | Deciphera Pharmaceuticals, LLC | 100 | 2025-09-03 | 2026-07-27 | |
| Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA Methotrexate (MTX), Placebo - Osteo Arthritis of the Knee, Synovitis of Knee | Phase 2 | Recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 70 | 2025-07-30 | 2025-09-12 |
| Light Therapy on Pain and Synovitis 810 nm Light Therapy, Sham Light Therapy - Knee Pain Chronic, Synovitis of Knee | Not applicable | Recruiting | The Hong Kong Polytechnic University | 80 | 2025-07-13 | 2025-11-26 |
| Efficacy and Safety of Etoricoxib/Betamethasone Combination in Acute Bursitis, Tendinitis and Synovitis Fixed Dose Etoricoxib + Betamethasone, Monotherapy Etoricoxib - Bursitis, Tendinitis | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 89 | 2025-05-14 | 2026-01-08 |
| Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis Arthritis, Arthritis, Rheumatoid | Not yet recruiting | University Hospital, Basel, Switzerland | 90 | 2025-05-01 | 2025-04-11 | |
| A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis Efanesoctocog alfa - Haemophilia A (Moderate or Severe), Hemophilia, Classic | Phase 4 | Active not recruiting | Swedish Orphan Biovitrum | 37 | 2024-12-19 | 2026-04-30 |
| Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT) Emactuzumab, Placebo - TGCT | Phase 3 | Active not recruiting | SynOx Therapeutics Limited | 128 | 2024-10-09 | 2026-07-29 |
| Efficacy Of Upadacitinib In Psoriatic Arthritis And Comparison To Rheumatoid Arthritis. Upadacitinib 15 MG [Rinvoq] - Rheumatoid Arthritis (RA, Psoriatic Arthritis (PsA | Unknown | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 178 | 2024-07-23 | 2024-10-08 | |
| Prevalence of Synovitis in Patients With Haemophilia A Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US); Haemophilia joint health score (HJHS) - Haemophilia A, Synovitis | Recruiting | University Hospital, Bonn | 300 | 2024-04-15 | 2024-04-16 | |
| A Real-World Study of Biologic Therapy for Subclinical Psoriatic Arthritis Biologics - Subclinical Psoriatic Arthritis | Enrolling by invitation | Chao Ji | 150 | 2023-11-01 | 2025-03-25 | |
| Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee Shoulder/Hip/Knee Embolization with Embozene Microspheres - Osteoarthritis, Knee, Osteoarthritis, Hip | Recruiting | Palo Alto Veterans Institute for Research | 120 | 2023-07-15 | 2025-08-07 | |
| Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER) Pimicotinib(ABSK021), Placebo - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis | Phase 3 | Active not recruiting | Abbisko Therapeutics Co, Ltd | 94 | 2023-04-27 | 2026-05-04 |
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Giant Cell Tumor of Tendon Sheath (22) · Arthritis, Rheumatoid (20) · Synovitis, Pigmented Villonodular (20) · Arthritis (11) · Hemophilia A (6) · Osteoarthritis (6) · Osteoarthritis, Knee (6) · Joint Diseases (5) · Arthritis, Psoriatic (4) · Pain (4) · Gout (3) · Arthritis, Reactive (2) · Autoimmune Diseases (2) · Musculoskeletal Diseases (2)
Musculoskeletal Diseases (79) · Joint Diseases (76) · Muscular Diseases (34) · Neoplasms by Histologic Type (32) · Neoplasms, Connective and Soft Tissue (31) · Tendinopathy (31) · Neoplasms (30) · Neoplasms, Connective Tissue (30) · Giant Cell Tumors (29) · Rheumatic Diseases (28) · Arthritis (22) · Immune System Diseases (22) · Skin and Connective Tissue Diseases (22) · Connective Tissue Diseases (19)
pexidartinib (7) · Methotrexate (5) · Etanercept (2) · Magnetic Resonance Spectroscopy (2) · Ultrasonography (2) · nilotinib (2) · Adalimumab (1) · Baclofen (1) · Betamethasone (1) · Bevacizumab (1) · Biological Products (1) · Bro protein, Drosophila (1) · Bupivacaine (1) · Capsaicin (1) · Chondroitin (1)
Daiichi Sankyo (6) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (5) · AmMax Bio, Inc. (3) · Deciphera Pharmaceuticals, LLC (3) · Abbisko Therapeutics Co, Ltd (2) · Assiut University (2) · Daiichi Sankyo Co., Ltd. (2) · Novartis Pharmaceuticals (2) · Peking University Third Hospital (2) · Plexxikon (2) · University of Alexandria (2) · AbbVie (1) · AbbVie (prior sponsor, Abbott) (1) · Andrew J. Wagner, MD, PhD (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1)
United States (33) · Italy (15) · France (14) · Netherlands (13) · China (11) · Spain (9) · United Kingdom (9) · Poland (8) · Canada (7) · Taiwan (6) · Australia (5) · Germany (5) · Hungary (4) · Norway (4) · Japan (3)
Dorothy Nguyen, MD (3) · Andre M Assis, MD, PhD (1) · Andreas C Strauss, PD Dr. med. (1) · Andrew J. Wagner, MD, PhD (1) · Anna Abou-Raya, MD (1) · Antonio Carroccio, PhD (1) · Antonio Manzo, MD PhD (1) · Bo Ejbjerg, MD, PhD (1) · Changhai Ding, MD (1)
PMID 33289960, PMID 21367761, PMID 21613624, PMID 22076476, PMID 22751595, PMID 22825366, PMID 22867975, PMID 24275240, PMID 24376248, PMID 24533607, PMID 25430806, PMID 25625764, PMID 25694210, PMID 25896862, PMID 27026689, PMID 27041409, PMID 28057477, PMID 29290809, PMID 29571946, PMID 30653843, PMID 30721294, PMID 31188797, PMID 31229240, PMID 32224746, PMID 32755241, PMID 32929463, PMID 32938470, PMID 33926503, PMID 34474649, PMID 34528079, PMID 35230489, PMID 35247274, PMID 35837703, PMID 35932628, PMID 36001000, PMID 36502615, PMID 36869793, PMID 37121591, PMID 37178368, PMID 37593881, PMID 38843860, PMID 39287124, PMID 39757775, PMID 40455462, PMID 40841499, PMID 41612350, PMID 41796601, PMID 42132251, PMID 42473802, PMID 42872549
2014 (1), 2015 (1)