24 completed, 13 recruiting, 7 active not recruiting, 5 terminated. 21 Phase 2, 8 Phase 1, 8 Phase 3, 5 Phase 4, 1 Early Phase 1.
Follow Giant Cell Tumors: new trials by email Literature Review of Giant Cell Tumors trials Research Report on Giant Cell Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| A Study of DCC-3014 to Evaluate the Efficacy, Safety, and Pharmacokinetics in Subjects With TGCT DCC-3014 - Tenosynovial Giant Cell Tumor | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 18 | 2026-10-31 | 2026-09-22 |
| Synovial Tissue as a Biomarker in the Management of Pigmented Villonodular Synovitis synovial biopsy - Synovitis Villonodular | Not applicable | Recruiting | Nantes University Hospital | 30 | 2026-09-01 | 2026-09-14 |
| Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER) Pimicotinib - Tenosynovial Giant Cell Tumor | Phase 2 | Recruiting | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 20 | 2026-03-26 | 2026-10-23 |
| Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone Surgery Indocyanine Green - Giant Cell Tumor of Bone | Phase 4 | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 40 | 2026-01-02 | 2026-01-05 |
| Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor Surgery Indocyanine Green - Tenosynovial Giant Cell Tumor | Phase 4 | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 40 | 2026-01-02 | 2026-01-05 |
| TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of Bone Tartrate-Resistant Acid Phosphatase 5b - Giant Cell Tumor of Bone, TRACP-5b | Recruiting | St. Anne's University Hospital Brno, Czech Republic | 70 | 2026-01-01 | 2026-05-27 | |
| MOVE: Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib Tenosynovial Giant Cell Tumor | Recruiting | Deciphera Pharmaceuticals, LLC | 100 | 2025-09-03 | 2026-07-27 | |
| PROMIS and Mobility Evaluation in Sarcoma Patients Surgery - Sarcoma, Giant Cell Tumor of Bone | Recruiting | University of Calgary | 800 | 2025-07-01 | 2025-11-13 | |
| Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT) Emactuzumab, Placebo - TGCT | Phase 3 | Active not recruiting | SynOx Therapeutics Limited | 128 | 2024-10-09 | 2026-07-29 |
| Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumors of Bone in Limbs: a Prospective, Single-center, Single-arm, Open Study ICG (Indocyanine Green) - Giant Cell Tumor of Bone | Phase 1 / Phase 2 | Recruiting | Tang Xiaodong | 45 | 2024-08-23 | 2024-10-18 |
| Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone XGEVA® - Giant Cell Tumor of Bone | Phase 4 | Active not recruiting | Amgen | 36 | 2023-08-17 | 2025-10-01 |
| Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER) Pimicotinib(ABSK021), Placebo - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis | Phase 3 | Active not recruiting | Abbisko Therapeutics Co, Ltd | 94 | 2023-04-27 | 2026-05-04 |
| InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer Samples - Cancer Risk, Cancer Predisposition Syndrome | Recruiting | Dana-Farber Cancer Institute | 5000 | 2023-04-25 | 2026-08-17 | |
| A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone Narlumosbart, Denosumab - Giant Cell Tumor of Bone | Phase 3 | Not yet recruiting | Shanghai JMT-Bio Inc. | 146 | 2023-04-01 | 2023-04-19 |
| Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage 4mg ZOL loaded gentamicin PMMA, gentamicin PMMA - Giant Cell Tumor of Bone | Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 153 | 2023-03-01 | 2023-03-15 |
| A Study to Evaluate Safety and Efficacy of AMB-05X Injections in Subjects With TGCT AMB-05X - Pigmented Villonodular Synovitis, TGCT | Phase 2 | Completed | AmMax Bio, Inc. | 20 | 2023-01-26 | 2024-07-05 |
| Oral Care of Patients Treated With Anti-RANK-ligand Antibodies for a Giant Cell Tumour Giant Cell Tumors | Completed | University Hospital, Strasbourg, France | 12 | 2022-09-01 | 2023-12-13 | |
| A Real-world Study on Patients of Unresectable Giant Cell Tumor of Bone Denosumab - Giant Cell Tumor of Bone | Completed | Shanghai JMT-Bio Inc. | 301 | 2021-11-10 | 2022-06-02 | |
| Study of Vimseltinib for Tenosynovial Giant Cell Tumor Vimseltinib, Placebo - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis | Phase 3 | Active not recruiting | Deciphera Pharmaceuticals, LLC | 123 | 2021-10-14 | 2026-03-20 |
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Giant Cell Tumor of Bone (22) · Giant Cell Tumor of Tendon Sheath (22) · Synovitis, Pigmented Villonodular (20) · Neoplasms (3) · Sarcoma (3) · Bone Neoplasms (2) · Synovitis (2) · Alzheimer Disease (1) · Arthritis, Rheumatoid (1) · Barrett Esophagus (1) · Carcinoma in Situ (1) · Carcinoma, Lobular (1) · Chondrosarcoma (1) · Chordoma (1)
Neoplasms by Histologic Type (55) · Neoplasms, Connective Tissue (55) · Neoplasms, Connective and Soft Tissue (55) · Neoplasms (52) · Musculoskeletal Diseases (33) · Muscular Diseases (30) · Tendinopathy (30) · Joint Diseases (29) · Synovitis (28) · Neoplasms, Bone Tissue (23) · Giant Cell Tumor of Tendon Sheath (8) · Neoplasms by Site (4) · Bone Diseases (3) · Nervous System Diseases (3)
Denosumab (10) · pexidartinib (7) · Indocyanine Green (3) · Vitamin D (2) · Zoledronic Acid (2) · nilotinib (2) · Amputation, Surgical (1) · Bro protein, Drosophila (1) · CTLA-4 Antigen (1) · Calcium (1) · Curettage (1) · Cyclophosphamide (1) · Dasatinib (1) · Ipilimumab (1) · Methods (1)
Daiichi Sankyo (6) · Amgen (4) · AmMax Bio, Inc. (3) · Deciphera Pharmaceuticals, LLC (3) · Peking University Third Hospital (3) · Shanghai JMT-Bio Inc. (3) · Abbisko Therapeutics Co, Ltd (2) · Daiichi Sankyo Co., Ltd. (2) · Istituto Ortopedico Rizzoli (2) · Plexxikon (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Shanghai Jiao Tong University Affiliated Sixth People's Hospital (2) · Andrew J. Wagner, MD, PhD (1) · Centre Leon Berard (1) · Changye Zou (1)
United States (26) · China (17) · Netherlands (15) · Italy (12) · France (11) · Poland (10) · Spain (10) · United Kingdom (10) · Canada (8) · Australia (7) · Taiwan (5) · Germany (4) · Hungary (3) · Japan (3) · Sweden (3)
Dorothy Nguyen, MD (3) · A H Taminiau, MD PhD (1) · Amir A Jazaeri (1) · Andrew J. Wagner, MD, PhD (1) · Changye Zou, MD (1) · Davide Donati, MD (1) · Emanuela Palmerini (1) · Guo Wei (1) · H Gelderblom, MD PhD (1)
PMID 21613624, PMID 31188797, PMID 32224746, PMID 33289960, PMID 37121591, PMID 37178368, PMID 41292259, PMID 17013643, PMID 25684041, PMID 27041409, PMID 27526293, PMID 28057477, PMID 29211870, PMID 29290809, PMID 29571946, PMID 30099641, PMID 30231890, PMID 31040253, PMID 31229240, PMID 32755241, PMID 33094400, PMID 33214476, PMID 33482769, PMID 33754215, PMID 33926503, PMID 35230489, PMID 35247274, PMID 35837703, PMID 35932628, PMID 36001000, PMID 36502615, PMID 36869793, PMID 37121582, PMID 37593881, PMID 3805057, PMID 38843860, PMID 39287124, PMID 39500883, PMID 40841499, PMID 41721625, PMID 41796601, PMID 42132251, PMID 42473802, PMID 42872549, PMID 4910256
2014 (1), 2017 (1), 2018 (1)