3 completed, 3 terminated, 1 active not recruiting, 1 recruiting. 8 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 3, Terminated 3, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
Follow Synovitis: new trials by email Literature Review of Synovitis trials Research Report on Synovitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid Tumor ABSK021 - Neoplasms, Tenosynovial Giant Cell Tumor | Phase 1 | Recruiting | Abbisko Therapeutics Co, Ltd | 276 | 2020-01-20 | 2026-11-09 |
| Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Tolbutamide, Midazolam, Pexidartinib - Drug Interaction Potential | Phase 1 | Completed | Daiichi Sankyo | 32 | 2018-02-26 | 2021-05-14 |
| Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor Vimseltinib - Advanced Malignant Neoplasm, Pigmented Villonodular Synovitis | Phase 1 / Phase 2 | Active not recruiting | Deciphera Pharmaceuticals, LLC | 120 | 2017-02-16 | 2026-06-25 |
| A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor PLX73086 - Solid Tumors, Tenosynovial Giant Cell Tumor | Phase 1 | Terminated | Plexxikon | 11 | 2016-02-01 | 2018-08-02 |
| Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor FPA008 - Pigmented Villonodular Synovitis, Tenosynovial Giant Cell Tumor | Phase 1 / Phase 2 | Completed | Five Prime Therapeutics, Inc. | 66 | 2015-06-01 | 2021-08-31 |
| Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Bevacizumab intra-articular injection - Hemophilia, Synovitis | Phase 1 | Terminated | National Taiwan University Hospital | 5 | 2014-02-01 | 2021-07-06 |
| Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors PLX7486 TsOH - Solid Tumor, Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations | Phase 1 | Terminated | Plexxikon | 59 | 2013-08-01 | 2018-08-02 |
| Positron Emission Tomography and Magnetic Resonance Imaging to Evaluate Synovial Blood Flow in Rheumatoid Arthritis Patients 15-O labeled water - Rheumatoid Arthritis | Phase 1 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 10 | 2001-04-01 | 2008-03-04 |
Giant Cell Tumor of Tendon Sheath (5) · Synovitis, Pigmented Villonodular (4) · Neoplasms (2) · Arthritis (1) · Arthritis, Rheumatoid (1) · Hemophilia A (1) · Joint Diseases (1)
Musculoskeletal Diseases (8) · Joint Diseases (7) · Giant Cell Tumors (6) · Muscular Diseases (6) · Neoplasms by Histologic Type (6) · Neoplasms, Connective Tissue (6) · Neoplasms, Connective and Soft Tissue (6) · Tendinopathy (6) · Neoplasms (4) · Autoimmune Diseases (1) · Blood Coagulation Disorders (1) · Blood Coagulation Disorders, Inherited (1) · Coagulation Protein Disorders (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Bevacizumab (1) · Bro protein, Drosophila (1) · Injections, Intra-Articular (1) · Midazolam (1) · Tolbutamide (1) · cabiralizumab (1) · pexidartinib (1)
Plexxikon (2) · Abbisko Therapeutics Co, Ltd (1) · Daiichi Sankyo (1) · Deciphera Pharmaceuticals, LLC (1) · Five Prime Therapeutics, Inc. (1) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (1) · National Taiwan University Hospital (1)
United States (7) · Netherlands (3) · France (2) · Poland (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · Canada (1) · China (1) · Italy (1) · New Zealand (1) · South Korea (1) · Spain (1)
Maitreyi Sharma, MD (1) · Shang-Ju Wu, MD (1) · Siqing Fu, MD (1)