3 completed, 3 not yet recruiting, 2 recruiting. 7 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 3, Not yet recruiting 2, Recruiting 2 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Symptomatic Apical Periodontitis: new trials by email Literature Review of Symptomatic Apical Periodontitis trials Research Report on Symptomatic Apical Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled Trial ProTaper Manual Root Canal Instrumentation, ProTaper Rotary Root Canal Instrumentation - Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis | Not applicable | Not yet recruiting | College of Physicians and Surgeons Pakistan | 200 | 2026-12-05 | 2026-10-21 |
| Photobiomodulation After Nonsurgical Root Canal Treatment Adjunctive Photobiomodulation, Sham Photobiomodulation - Symptomatic Apical Periodontitis, Postoperative Pain | Not applicable | Not yet recruiting | University of Minnesota | 60 | 2026-10-19 | 2026-10-21 |
| Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis Calcium Hydroxide (Ca(OH)2), Bioceramic Intracanal Medicament - Symptomatic Apical Periodontitis | Not applicable | Recruiting | Future University in Egypt | 28 | 2026-06-01 | 2026-09-25 |
| Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars Group B: patients will be given prednisolone 20mg as premedication, piroxicam 20mg - Irreversible Pulpitis With Apical Periodontitis, Symptomatic Apical Periodontitis | Phase 4 | Not yet recruiting | RANA AHMAD | 60 | 2026-01-01 | 2025-12-15 |
| Comparison of Postoperative Pain After Double Antibiotic Paste vs Calcium Hydroxide in Teeth With Symptomatic Apical Periodontitis Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste - Symptomatic Apical Periodontitis | Not applicable | Recruiting | College of Physicians and Surgeons Pakistan | 662 | 2025-09-05 | 2026-10-09 |
| Effect of Anterior Disc Displacement With Reduction on Postoperative Pain After Root Canal Treatment Single-Visit Conventional Root Canal Treatment Using Nickel-Titanium Rotary Instruments (Endoart Smart Gold), Ibuprofen 400 mg (if necessary) - Symptomatic Apical Periodontitis, Temporomandibular Disorders (TMDs) | Not applicable | Completed | Recep Tayyip Erdogan University | 70 | 2025-03-10 | 2026-01-09 |
| Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth Valacyclovir, Placebo - Symptomatic Apical Periodontitis | Not applicable | Completed | Tehran University of Medical Sciences | 38 | 2024-11-01 | 2025-06-11 |
| Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis Placement of calcium hydroxide as an intracanal medicament, Placement of metformin as an intracanal medicament, Application of calcium hydroxide as an intracanal medicament together with intracanal cryotherapy - Symptomatic Apical Periodontitis, Pulp Necrosis | Not applicable | Completed | Celalettin Topbaş | 80 | 2023-03-01 | 2026-09-16 |
Pain, Postoperative (4) · Periapical Periodontitis (2) · Dental Pulp Diseases (1) · Dental Pulp Necrosis (1) · Hyperalgesia (1) · Pain (1) · Temporomandibular Joint Disorders (1)
Pathological Conditions, Signs and Symptoms (6) · Neurologic Manifestations (5) · Pathologic Processes (5) · Signs and Symptoms (5) · Pain (4) · Postoperative Complications (4) · Stomatognathic Diseases (4) · Jaw Diseases (3) · Mouth Diseases (2) · Periapical Diseases (2) · Periodontal Diseases (2) · Periodontitis (2) · Tooth Diseases (2) · Craniomandibular Disorders (1) · Dental Pulp Diseases (1)
Calcium Hydroxide (2) · Ibuprofen (1) · Piroxicam (1) · Premedication (1) · Valacyclovir (1)
College of Physicians and Surgeons Pakistan (2) · Celalettin Topbaş (1) · Future University in Egypt (1) · RANA AHMAD (1) · Recep Tayyip Erdogan University (1) · Tehran University of Medical Sciences (1) · University of Minnesota (1)
Turkey (Türkiye) (2) · Egypt (1) · Iran (1) · Pakistan (1) · United States (1)
Adel Abdelwahed, Prof. Ass. of endodontic (1) · Ronald Ordinola-Zapata (1)