87 completed, 12 recruiting, 8 terminated, 7 unknown. 39 Phase 2, 30 Phase 1, 19 Not applicable, 19 Phase 4, 17 Phase 3.
Follow Valacyclovir: new trials by email Literature Review of Valacyclovir trials Research Report on Valacyclovir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2027-01-01 | 2026-10-28 |
| SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Valacyclovir, Celecoxib, Paxlovid - Post-acute Sequelae of COVID-19, Long COVID | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-10-20 | 2026-10-28 |
| Aglatimagene Besadenovec + Prodrug and Pembrolizumab vs Docetaxel for Stage IV Non-Squamous NSCLC Progressing on Pembrolizumab (AURORA) Aglatimagene Besadenovec, Valacyclovir, Pembrolizumab - Non-squamous, Non-Small Cell Lung Cancer | Phase 3 | Recruiting | Candel Therapeutics, Inc. | 500 | 2026-06-15 | 2026-06-22 |
| Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors Ad-hCMV-Flt3L, Ad-hCMV-TK, Biospecimen Collection - Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Malignant Brain Neoplasm | Phase 1 | Recruiting | University of Michigan Rogel Cancer Center | 11 | 2026-05-22 | 2026-06-15 |
| Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma TGX-007, Valaciclovir - Glioblastoma (GBM), High Grade Gliomas | Phase 1 / Phase 2 | Recruiting | Trogenix ltd | 68 | 2026-04-21 | 2026-10-23 |
| Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study Valacyclovir (Valtrex), Valganciclovir (Valcyte) - Kidney Transplantation, Cytomegalovirus Infections, EBV Infection | Not applicable | Recruiting | National Taiwan University Hospital | 80 | 2025-11-27 | 2025-12-19 |
| A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene Besadenovec aglatimagene besadenovec + valacyclovir, External Beam Radiation Therapy (EBRT) - Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Candel Therapeutics, Inc. | 45 | 2025-10-30 | 2026-09-15 |
| Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation Acupuncture, Sham, Valacyclovir, pregabalin and mecobalamin - Acute Herpes Zoster | Not applicable | Recruiting | Dexiong Han | 228 | 2025-09-01 | 2026-06-16 |
| Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth Valacyclovir, Placebo - Symptomatic Apical Periodontitis | Not applicable | Completed | Tehran University of Medical Sciences | 38 | 2024-11-01 | 2025-06-11 |
| Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening Valacyclovir 500 mg, Naproxen Sodium 550mg - Acute Apical Abscess | Phase 4 | Unknown | Dow University of Health Sciences | 82 | 2024-03-27 | 2024-04-10 |
| Valacyclovir in Pain Management of Acute Apical Abscesses Valacyclovir 500 MG, Placebo - Acute Apical Abscess, Pain, Acute | Phase 2 | Recruiting | University of California, San Francisco | 60 | 2023-10-25 | 2025-05-30 |
| Prenatal Treatment of Congenital Cytomegalovirus Infection With Letermovir Versus Valaciclovir Letermovir, Valacyclovir - Pregnant Women, CMV Infected Fetuses | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 46 | 2023-10-20 | 2026-03-31 |
| A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis BD111 Injection (Investigative New Drug), Triple-drugs therapy of HSV-1 stromal keratitis - Herpes Simplex Virus Type I Stromal Keratitis | Phase 1 | Active not recruiting | Shanghai BDgene Co., Ltd. | 16 | 2023-09-04 | 2025-05-18 |
| Neonatal Phase 1 Valacyclovir Study Valacyclovir - Herpes Simplex | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 17 | 2023-08-07 | 2026-07-23 |
| VZV in the Enteric Nervous System: Pathogenesis and Consequences ValACYclovir 1000 MG, Shingrix - Achalasia | Phase 4 | Recruiting | Vanderbilt University Medical Center | 40 | 2023-03-27 | 2026-10-05 |
| Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia Valacyclovir + Paracetamol (Acetaminophen) + Gabapentin (standard medical therapy), Ultrasound-guided thoracic paravertebral block (TPVB) with bupivacaine 0.25% + methylprednisolone 40 mg - Postherpetic Neuralgia | Phase 3 | Completed | Assiut University | 100 | 2023-03-15 | 2026-01-20 |
| Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) Pirtobrutinib, Obinutuzumab, Venetoclax - Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 60 | 2022-12-20 | 2026-04-30 |
| A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster Peginterferon α1b, Peginterferon α1b with valacyclovir, Valacyclovir - Herpes Zoster | Phase 2 | Completed | Shanghai Institute Of Biological Products | 50 | 2022-10-11 | 2023-12-29 |
| Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy Valacyclovir, Placebo - Oral Mucositis, Head and Neck Cancer (H&N) | Phase 2 | Enrolling by invitation | Instituto Oncoclinicas | 84 | 2022-09-05 | 2026-01-23 |
| Using Oral Valacyclovir to Treat Patients With Refractory IC/BPS Valacyclovir - Pain, Chronic, Urge Incontinence | Phase 1 | Unknown | Buddhist Tzu Chi General Hospital | 30 | 2021-07-01 | 2021-10-26 |
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Herpes Simplex (25) · Herpes Genitalis (21) · HIV Infections (17) · Herpes Zoster (15) · Acquired Immunodeficiency Syndrome (6) · Cytomegalovirus Infections (6) · Glioblastoma (5) · Neuralgia, Postherpetic (5) · Chickenpox (4) · Glioma (4) · Prostatic Neoplasms (4) · Recurrence (4) · Sexually Transmitted Diseases (4) · AIDS-Related Complex (3) · Anus Diseases (3)
Candel Therapeutics, Inc. (11) · University of Washington (9) · GlaxoSmithKline (8) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Glaxo Wellcome (4) · Astellas Pharma Inc (3) · M.D. Anderson Cancer Center (3) · Mylan Pharmaceuticals Inc (3) · Radboud University Medical Center (3) · Assistance Publique - Hôpitaux de Paris (2) · Baylor College of Medicine (2) · Dr. Reddy's Laboratories Limited (2) · Fred Hutchinson Cancer Center (2) · NYU Langone Health (2) · Ranbaxy Laboratories Limited (2)
United States (73) · Canada (12) · United Kingdom (7) · China (4) · India (4) · Netherlands (4) · Australia (3) · Brazil (3) · France (3) · Germany (3) · Sweden (3) · Argentina (2) · Chile (2) · Japan (2) · Kenya (2)
Anna Wald, MD, MPH (3) · Connie Celum, MD, MPH (3) · Dorian Williams, M.D. (3) · Alan Copa, PharmD (2) · Christine Johnston, MD, MPH (2) · Darrell HS Tan, MD FRCPC (2) · Davangere Devanand, MD (2) · Dr. Dharmesh Domadia, MD (2) · E. Antonio Chiocca, MD, PhD (2) · Mary J Burton, MD (2) · Sharon L Walmsley, MD FRCPC MSc (2) · Susan Blaney, MD (2)
PMID 22225814, PMID 16044019, PMID 17314338, PMID 17617198, PMID 18008230, PMID 18039954, PMID 18368417, PMID 18593294, PMID 18596069, PMID 18849193, PMID 18928378, PMID 19169140, PMID 19192993, PMID 19469706, PMID 21482862, PMID 21844505, PMID 21998479, PMID 22147786, PMID 22446565, PMID 22509337, PMID 22652942, PMID 22711350, PMID 22852760, PMID 23946220, PMID 24504006, PMID 24664172, PMID 25795132, PMID 25956891, PMID 26312852, PMID 26843484, PMID 27162003, PMID 27450392, PMID 27943311, PMID 27997653, PMID 28437539, PMID 28800385, PMID 29550074, PMID 30102389, PMID 30883662, PMID 32034019, PMID 32919517, PMID 33160076, PMID 35090154, PMID 37011709, PMID 38411973, PMID 38540138, PMID 39133650, PMID 40048183, PMID 40048191, PMID 40120123
2009 (1), 2016 (1), N01AI30025 (1), P01AI030731 (1), R01AG055422 (1), R03HD057773 (1), U10EY026869 (1), U54AI150225 (1), UM1CA137443 (1)