177 completed, 46 recruiting, 30 unknown, 18 active not recruiting. 253 Not applicable, 16 Phase 2, 8 Phase 1, 5 Phase 3, 3 Phase 4.
Follow Substance Use: new trials by email Literature Review of Substance Use trials Research Report on Substance Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Permanent Supportive Housing Overdose Prevention+ Study TA Intervention - Overdose, Substance Use | Not applicable | Not yet recruiting | NYU Langone Health | 2940 | 2027-07-01 | 2026-05-06 |
| Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders METS4Vets - Substance Use | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-06-01 | 2026-10-05 |
| Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT Acceptance and Commitment Therapy, Attention Control - Prevention, Substance Use | Not applicable | Not yet recruiting | Boston Medical Center | 144 | 2027-04-01 | 2026-06-29 |
| Improving HIV Prevention and Substance Use Post-Sexual Assault Services Enhanced intervention, Usual Care - HIV Infections, Substance Use | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 90 | 2027-01-04 | 2025-11-05 |
| Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-01 | 2026-10-07 |
| A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs LINKED, Group Intervention - Substance Use, HIV Prevention | Not applicable | Not yet recruiting | NYU Langone Health | 398 | 2027-01-01 | 2026-11-10 |
| Linking Individuals Needing Care for Substance Use Disorders to Peer Coaches & Across INcarceration Settings Virtual Peer Recovery Coaching, Treatment as Usual - Substance Use | Not applicable | Recruiting | Emory University | 550 | 2027-01-01 | 2026-11-10 |
| mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System LYNX, Standard of Care - HIV Prevention, Substance Use | Not applicable | Not yet recruiting | University of Pittsburgh | 50 | 2026-12-01 | 2026-10-20 |
| Mindfulness-Based Substance Use Prevention (MINDS-UP) MINDS-UP, Prevention Plus Wellness - Substance Use | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 40 | 2026-10-01 | 2026-09-25 |
| Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors WHO ASSIST v3.1 Screening with Feedback, ASSIST Linked Brief Intervention (10 Step Motivational interviewing (MI)/FRAMES), WHO ASSIST v3.1 Screening (No Feedback) - Survivors of Childhood Cancer, Substance Use | Not applicable | Recruiting | St. Jude Children's Research Hospital | 30 | 2026-10-01 | 2026-09-03 |
| CBITS-RTM Pilot Study Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM) - PTSD - Post Traumatic Stress Disorder, Substance Use | Not applicable | Not yet recruiting | University of California, San Francisco | 28 | 2026-09-01 | 2026-07-06 |
| Mobile Technology to Reduce Teen Substance Misuse WisePath for Teens, Peer Support Services (PSS), Control - Substance Use, Substance Abuse | Not applicable | Recruiting | Evidence-Based Practice Institute, Seattle, WA | 600 | 2026-08-18 | 2026-08-20 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| iPAWS: Improving Pain Management After Wisdom Tooth Extraction Surgery iPAWS, Educational Materials - Pain, Postoperative, Substance Use | Not applicable | Recruiting | Brown University | 150 | 2026-06-29 | 2026-07-28 |
| Neuroimaging of Adolescent Cannabis Use Treatment Contingency Management, Elastic Net Regression - Cannabis Use, Cannabis Dependence | Not applicable | Recruiting | Indiana University | 80 | 2026-06-15 | 2026-06-22 |
| Testing and Evaluation of the Returning to the Land Intervention to Address and Prevent Substance Misuse Returning to the Land - Biodiverse Outdoor Setting, Control - Substance Use, Children | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 60 | 2026-06-15 | 2026-08-05 |
| Home Visitation Enhancing Linkages Project in Kansas e-SBI main session, e-SBI Booster Session, Text messaging - Substance Use | Not applicable | Recruiting | The National Center on Addiction and Substance Abuse at Columbia University | 120 | 2026-06-01 | 2026-10-21 |
| Project REACH: A Comprehensive Telehealth Intervention at Syringe Service Programs to Engage People Who Use Drugs Project REACH - Substance Use, Drug Use | Not applicable | Recruiting | University of Minnesota | 121 | 2026-05-06 | 2026-05-19 |
| Finding Emotional Empowerment and Lifelong Strength Finding Emotional Empowerment and Lifelong Strength - Trauma and Stressor Related Disorders, Substance Use | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 80 | 2026-03-10 | 2026-06-18 |
| Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD) | Not yet recruiting | Assiut University | 102 | 2026-03-01 | 2026-02-09 |
Showing 20 of 304. Sign in to see all of them.
Substance-Related Disorders (304) · Depression (24) · Alcohol Drinking (19) · Psychological Well-Being (18) · Acquired Immunodeficiency Syndrome (16) · HIV Infections (16) · Anxiety Disorders (15) · Mental Disorders (11) · Opioid-Related Disorders (11) · Sexually Transmitted Diseases (11) · Adolescent Behavior (10) · Alcoholism (9) · Social Stigma (8) · Marijuana Abuse (7) · Psychotic Disorders (7)
Chemically-Induced Disorders (304) · Mental Disorders (293) · Behavior (124) · Infections (42) · Urogenital Diseases (40) · Genital Diseases (38) · Communicable Diseases (37) · Virus Diseases (34) · Immune System Diseases (33) · RNA Virus Infections (33) · Behavioral Symptoms (31) · Blood-Borne Infections (31) · Lentivirus Infections (31) · Retroviridae Infections (31) · Sexually Transmitted Diseases, Viral (31)
Therapeutics (11) · Control Groups (6) · Ethanol (6) · Motivational Interviewing (5) · Standard of Care (5) · Case Management (4) · Surveys and Questionnaires (4) · Acceptance and Commitment Therapy (3) · Exercise (3) · Methods (3) · Creatine (2) · Crisis Intervention (2) · Dosage Forms (2) · Educational Status (2) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (2)
Johns Hopkins Bloomberg School of Public Health (10) · University of Michigan (8) · University of California, Los Angeles (7) · University of California, San Francisco (7) · Yale University (7) · Hunter College of City University of New York (6) · Medical University of South Carolina (6) · Ohio State University (6) · University of Miami (6) · University of Washington (6) · Brown University (5) · RAND (5) · RTI International (5) · University of Colorado, Denver (5) · University of Oregon (5)
United States (236) · Canada (14) · South Africa (4) · Thailand (4) · Chile (3) · Spain (3) · Turkey (Türkiye) (3) · Kenya (2) · Russia (2) · Switzerland (2) · United Kingdom (2) · China (1) · Egypt (1) · Ethiopia (1) · France (1)
Allison Lin, MD (2) · Angela Heads, PhD (2) · Bryan R Garner, PhD (2) · Chyrell Bellamy, Ph.D. (2) · Howard A Liddle, EdD (2) · Jessica F Magidson, PhD (2) · Jiang Du, M.D (2) · John R Knight, MD (2) · Kasey Claborn, PhD (2) · Katherine Elkington, PhD (2) · Kimberly Bender, PhD (2) · Mary Cwik, PhD (2) · Maureen Walton, MPH, PHD (2) · Nancy R Whitesell, PhD (2) · Nittaya Phanuphak, MD,PhD. (2)
PMID 37393415, PMID 41085955, PMID 10377201, PMID 10689661, PMID 11219370, PMID 12144608, PMID 12186831, PMID 12526074, PMID 15241694, PMID 15812614, PMID 16055882, PMID 16264058, PMID 16443717, PMID 17084887, PMID 18519478, PMID 18657569, PMID 18686156, PMID 18783499, PMID 19542037, PMID 19683400, PMID 20080363, PMID 20217471, PMID 20414477, PMID 21073486, PMID 21315539, PMID 21318929, PMID 21408154, PMID 21552345, PMID 21646576, PMID 21720782, PMID 21840130, PMID 21909303, PMID 21969363, PMID 22020758, PMID 22138539, PMID 22142170, PMID 22443839, PMID 22530986, PMID 22564202, PMID 22638007, PMID 22893231, PMID 23683980, PMID 23750466, PMID 23852281, PMID 23867137, PMID 23890774, PMID 24138347, PMID 24139017, PMID 24290208, PMID 24308013
K23DA050808 (2), P30MH123248 (2), R01DA038146 (2), R01DA050521 (2), 2017 (1), 4UH3DA044798-03 (1), 5IK2HX002612-02 (1), D43TW009345 (1), DP2DA049296-01 (1), DP2DA056107 (1), F31AA028751 (1), F31DA058452 (1), K01DA048201 (1), K01DA060294 (1), K01MD013910 (1)