13 completed. 13 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Phase 2 | 2 | Completed 2 |
Follow Status Epilepticus: new trials by email Literature Review of Status Epilepticus trials Research Report on Status Epilepticus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus Ketamine, Midazolam, Placebo - Generalized Convulsive Status Epilepticus | Phase 2 / Phase 3 | Completed | Sohag University | 144 | 2023-03-21 | 2024-10-29 |
| Randomized Therapy In Status Epilepticus Ganaxolone, Placebo - Status Epilepticus | Phase 3 | Completed | Marinus Pharmaceuticals | 100 | 2020-12-09 | 2025-05-29 |
| Established Status Epilepticus Treatment Trial Fosphenytoin, Levetiracetam, Valproic acid - Benzodiazepine Refractory Status Epilepticus | Phase 3 | Completed | University of Virginia | 478 | 2015-10-01 | 2021-06-14 |
| Lorazepam for the Treatment of Status Epilepticus or Repetitive Status Epilepticus in Japan Lorazepam - Status Epilepticus | Phase 3 | Completed | Pfizer | 26 | 2014-11-01 | 2019-02-18 |
| Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus Clonazepam, Fosphenytoin, Placebo - Status Epilepticus, Epilepsy | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 434 | 2013-06-26 | 2018-10-11 |
| Evaluation of Therapeutic Hypothermia in Convulsive Status EPILEPTICUS in Adults in Intensive Care Moderate hypothermia - Convulsive Status EPILEPTICUS | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 270 | 2010-12-01 | 2016-09-29 |
| Refractory Status Epilepticus Treatment Study valproic acid (VPA) - Grand Mal Status Epilepticus, Non-convulsive Status Epilepticus | Phase 3 | Completed | Hospital Universitari de Bellvitge | 5 | 2010-01-01 | 2013-03-12 |
| Study of Antiepileptic Drug in Generalised Convulsive Status Epilepticus Levetiracetam/Clonazepam, Clonazepam/Placebo levetiracetam IV - Status; Epilepticus, Tonic-clonic | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 203 | 2009-07-01 | 2026-01-15 |
| Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications Intramuscular route of active treatment, Intravenous route of active treatment - Status Epilepticus | Phase 3 | Completed | Robert Silbergleit | 1023 | 2009-06-01 | 2016-06-17 |
| Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children Lorazepam - Status Epilepticus, Seizures | Phase 3 | Completed | All India Institute of Medical Sciences | 140 | 2008-05-01 | 2009-05-05 |
| Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2) lorazepam or diazepam - Status Epilepticus | Phase 2 / Phase 3 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 259 | 2008-02-01 | 2012-12-18 |
| Intranasal Lorazepam Versus Intramuscular Paraldehyde in Paediatric Convulsions intranasal lorazepam, intramuscular paraldehyde - Status Epilepticus, Convulsions | Phase 3 | Completed | Kamuzu University of Health Sciences | 156 | 2004-07-01 | 2006-07-21 |
| Phase III Randomized Study of Diazepam Vs Lorazepam Vs Placebo for Prehospital Treatment of Status Epilepticus diazepam, lorazepam - Status Epilepticus | Phase 3 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 210 | 1995-11-01 | 2005-06-24 |
Seizures (7) · Epilepsy (3) · Mental Disorders (1) · Neurologic Manifestations (1) · Rare Diseases (1)
Nervous System Diseases (13) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Neurologic Manifestations (12) · Seizures (6) · Brain Diseases (3) · Central Nervous System Diseases (3) · Disease Attributes (1) · Pathologic Processes (1)
Lorazepam (6) · Clonazepam (2) · Diazepam (2) · Levetiracetam (2) · Valproic Acid (2) · fosphenytoin (2) · Benzodiazepines (1) · Hypothermia, Induced (1) · Ketamine (1) · Midazolam (1) · Phenytoin (1) · ganaxolone (1)
Assistance Publique - Hôpitaux de Paris (3) · All India Institute of Medical Sciences (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Hospital Universitari de Bellvitge (1) · Kamuzu University of Health Sciences (1) · Marinus Pharmaceuticals (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Pfizer (1) · Robert Silbergleit (1) · Sohag University (1) · University of Virginia (1)
United States (4) · France (3) · Canada (2) · Australia (1) · Egypt (1) · India (1) · Japan (1) · Malawi (1) · Spain (1)
James Chamberlain, MD (2) · Robert Silbergleit, MD (2) · Abdelrahim A Sadek, MD, PhD (1) · Daniel H Lowenstein, MD (1) · Daniel Lowenstein (1) · Elizabeth Molyneux, MRCPCH FFAEM (1) · Jaideep Kapur, MBBS, PhD (1) · Jordan Elm, PhD (1) · Pierre Carli, MD, PhD (1) · Shafique Ahmad, MRCPCH FFAEM (1)
PMID 16698412, PMID 21275979, PMID 21967361, PMID 21967362, PMID 22335736, PMID 22506949, PMID 24001080, PMID 24756515, PMID 26627366, PMID 27325409, PMID 27993298, PMID 28002714, PMID 31161706, PMID 31774955, PMID 32203691, PMID 32446674, PMID 32913029, PMID 33336359, PMID 33567109, PMID 33742783, PMID 34032604, PMID 35718575, PMID 35987977, PMID 37286846
2017 (1), U01NS056975 (1), U01NS088034 (1)