33 completed, 13 terminated, 1 active not recruiting, 1 unknown. 22 Phase 1, 22 Phase 2, 3 Not applicable, 3 Phase 3, 1 Early Phase 1.
Follow Stage IV Rectal Cancer: new trials by email Literature Review of Stage IV Rectal Cancer trials Research Report on Stage IV Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites Canady Helios Cold Plasma Scalpel - Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer | Not applicable | Unknown | Jerome Canady, M.D. | 20 | 2019-07-30 | 2021-08-09 |
| Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer ATP128, BI 754091, VSV-GP128 - Colorectal Cancer, MSS | Phase 1 | Active not recruiting | Amal Therapeutics | 96 | 2019-07-22 | 2025-01-29 |
| Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Best Practice, Laboratory Biomarker Analysis, Supportive Care - Acute Myeloid Leukemia, Brain Glioblastoma | Not applicable | Completed | Stanford University | 128 | 2017-08-08 | 2025-01-24 |
| Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy cytology specimen collection procedure, laboratory biomarker analysis, questionnaire administration - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Terminated | Fox Chase Cancer Center | 6 | 2013-10-01 | 2018-02-07 | |
| Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab panitumumab, irinotecan hydrochloride, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 16 | 2013-02-01 | 2025-02-05 |
| Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer aflibercept, oxaliplatin, leucovorin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 56 | 2012-11-14 | 2025-02-05 |
| Vaccine Therapy in Treating Patients With Colorectal, Stomach, or Pancreatic Cancer laboratory biomarker analysis, enzyme-linked immunosorbent assay, flow cytometry - Recurrent Colon Cancer, Recurrent Gastric Cancer | Phase 1 | Completed | City of Hope Medical Center | 12 | 2011-12-22 | 2026-10-19 |
| Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer irinotecan hydrochloride, leucovorin calcium, fluorouracil - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | City of Hope Medical Center | 3 | 2011-08-30 | 2026-10-16 |
| Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer AUY922, Cetuximab - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | Swedish Medical Center | 20 | 2011-02-01 | 2015-06-08 |
| Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors veliparib, capecitabine, oxaliplatin - Adenocarcinoma of the Pancreas, Adenocarcinoma of the Stomach | Phase 1 | Terminated | National Cancer Institute (NCI) | 16 | 2010-10-01 | 2014-04-02 |
| Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy panobinostat, fluorouracil, leucovorin calcium - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Terminated | University of Southern California | 7 | 2010-10-01 | 2015-05-27 |
| Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 4 | 2010-10-01 | 2021-12-20 |
| High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and Bevacizumab as First-Line Therapy For Metastatic Colorectal Cancer leucovorin calcium, bevacizumab, cholecalciferol - Stage IV Colon Cancer, Stage IV Rectal Cancer | Phase 2 | Terminated | Roswell Park Cancer Institute | 10 | 2010-08-01 | 2014-07-21 |
| RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors gamma-secretase/Notch signalling pathway inhibitor RO4929097, capecitabine, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2010-06-01 | 2014-11-07 |
| RO4929097 in Treating Patients With Metastatic Colorectal Cancer gamma-secretase/Notch signalling pathway inhibitor RO4929097, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2010-05-01 | 2014-05-20 |
| Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer entinostat, azacitidine, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 47 | 2010-04-01 | 2014-08-01 |
| Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery cetuximab, dasatinib, therapeutic conventional surgery - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Early Phase 1 | Terminated | National Cancer Institute (NCI) | 9 | 2009-12-01 | 2014-05-23 |
| Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer PD-0332991 - Adult Solid Tumor, Adenocarcinoma of the Colon | Phase 2 | Completed | Abramson Cancer Center at Penn Medicine | 304 | 2009-10-01 | 2021-03-11 |
| Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer sorafenib tosylate, bevacizumab - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | Alliance for Clinical Trials in Oncology | 83 | 2009-09-01 | 2026-01-20 |
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Colonic Neoplasms (48) · Rectal Neoplasms (48) · Pancreatic Neoplasms (11) · Breast Neoplasms (9) · Carcinoma, Non-Small-Cell Lung (9) · Stomach Neoplasms (9) · Carcinoma, Hepatocellular (7) · Colorectal Neoplasms (6) · Salivary Gland Neoplasms (6) · Breast Neoplasms, Male (5) · Carcinoma, Ovarian Epithelial (5) · Esophageal Neoplasms (5) · Gallbladder Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5) · Anus Neoplasms (4)
Colonic Diseases (47) · Digestive System Diseases (47) · Digestive System Neoplasms (47) · Gastrointestinal Diseases (47) · Intestinal Diseases (47) · Intestinal Neoplasms (47) · Neoplasms by Site (47) · Rectal Diseases (47) · Gastrointestinal Neoplasms (46) · Neoplasms (46) · Colorectal Neoplasms (42) · Neoplasms by Histologic Type (13) · Endocrine Gland Neoplasms (12) · Endocrine System Diseases (12) · Carcinoma (11)
Fluorouracil (12) · Leucovorin (12) · Oxaliplatin (9) · Bevacizumab (7) · Cetuximab (7) · Irinotecan (7) · Capecitabine (5) · Erlotinib Hydrochloride (4) · Floxuridine (3) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (2) · Dasatinib (2) · Gene Expression Profiling (2) · Granulocyte-Macrophage Colony-Stimulating Factor (2) · Sorafenib (2) · Vorinostat (2)
National Cancer Institute (NCI) (30) · City of Hope Medical Center (3) · Fox Chase Cancer Center (2) · John Hays (2) · Roswell Park Cancer Institute (2) · Abramson Cancer Center at Penn Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Amal Therapeutics (1) · Jerome Canady, M.D. (1) · National Institutes of Health Clinical Center (CC) (1) · Stanford University (1) · Swedish Medical Center (1) · University of California, San Francisco (1) · University of Southern California (1)
United States (46) · Canada (3) · Belgium (1) · Germany (1) · Switzerland (1)
John Hays, MD (2) · Alain Mita (1) · Allyson Ocean (1) · Amit Oza (1) · Antonius Miller (1) · Axel Grothey, MD (1) · Bruce Giantonio (1) · Cathy Eng (1) · Charles Blanke (1) · Chloe E Atreya, MD, PhD (1) · Efrat Dotan (1) · Efrat Dotan, MD (1) · Emily Chan (1) · H. Richard Alexander, Jr. (1) · Hedy Kindler (1)
PMID 20048179, PMID 21208843, PMID 24583822, PMID 24987057, PMID 32201506, PMID 32641862, PMID 32692450, PMID 34749008, PMID 35771552, PMID 37509349, PMID 38314087
N01CM17003 (2), N01CM62201 (2), N01CM62202 (2), P30CA014520 (2), P30CA068485 (2), U01CA062491 (2), U10CA021115 (2), U10CA025224 (2), 2019 (1), N01CM00038 (1), N01CM00099 (1), N01CM17107 (1), N01CM62203 (1), N01CM62204 (1), N01CM62208 (1)