161 completed, 60 terminated, 17 active not recruiting, 15 withdrawn. 170 Phase 1, 150 Phase 2, 9 Phase 3, 5 Not applicable, 4 Early Phase 1.
Follow Vorinostat: new trials by email Literature Review of Vorinostat trials Research Report on Vorinostat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab Radiation: 131I-MIBG, Dinutuximab, Vorinostat - Neuroblastoma | Phase 2 | Not yet recruiting | New Approaches to Neuroblastoma Therapy Consortium | 118 | 2026-12-31 | 2026-08-21 |
| Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population Vorinostat - GVHD | Phase 2 | Recruiting | Sung Won Choi | 55 | 2026-12-01 | 2026-10-16 |
| Safety and Effectiveness of A-dmDT390-bisFv(UCHT1) Fusion Protein in Subjects With Mycosis Fungoides A-dmDT390-bisFv(UCHT1), Vorinostat - Mycosis Fungoides | Phase 2 | Withdrawn | Virogen Biotechnology Inc. | 2026-05-01 | 2026-05-18 | |
| An Exploratory Evaluation of the Safety and Efficacy of Vorinostat in Pitt Hopkins Syndrome Vorinostat (SAHA), Placebo - Pitt Hopkins Syndrome | Phase 1 | Recruiting | Unravel Biosciences, Inc. | 5 | 2026-03-15 | 2026-09-17 |
| Rett REVOLUTION Trial: An Exploratory Evaluation of the Safety and Efficacy of Vorinostat in Rett Syndrome Vorinostat (SAHA), Placebo - Rett Syndrome | Phase 1 | Recruiting | Unravel Biosciences, Inc. | 15 | 2026-03-15 | 2026-09-17 |
| A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST] mirdametinib and vorinostat - Primary Malignant Peripheral Nerve Sheath Tumors | Early Phase 1 | Recruiting | University of Minnesota | 8 | 2025-11-20 | 2026-05-29 |
| The DART DELIVER-02 Study MGD020, MGD014, Vorinostat - HIV (Human Immunodeficiency Virus) | Phase 1 | Suspended | University of North Carolina, Chapel Hill | 24 | 2025-10-02 | 2026-09-22 |
| Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC Cisplatin, Radiation therapy, Vorinostat - HPV-Related Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Oral Cavity | Phase 2 | Withdrawn | Case Comprehensive Cancer Center | 2025-06-01 | 2025-04-04 | |
| Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease Vorinostat - Cushing's Disease | Phase 2 | Withdrawn | National Institute of Neurological Disorders and Stroke (NINDS) | 2025-04-11 | 2025-04-15 | |
| Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer Biopsy Procedure, Biospecimen Collection, Bone Scan - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 15 | 2024-09-18 | 2026-08-06 |
| Ph1 Study of FT538 Alone and With Vorinostat for Persistent Low-Level HIV Viremia FT538, Vorinostat - HIV-1-infection, ART | Phase 1 | Withdrawn | Masonic Cancer Center, University of Minnesota | 2024-07-15 | 2024-02-26 | |
| TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II Dexamethasone, Mitoxantrone, PEG asparaginase - Lymphoblastic Leukemia | Phase 1 / Phase 2 | Recruiting | Tanja Andrea Gruber | 90 | 2023-11-03 | 2026-06-03 |
| Venetoclax to Augment Epigenetic Modification and Chemotherapy Venetoclax, Azacitadine, Vorinostat - Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory | Phase 1 | Recruiting | Medical College of Wisconsin | 40 | 2023-03-31 | 2026-01-12 |
| Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy Sodium Thiosulfate - Ototoxicity, Drug-Induced | Early Phase 1 | Suspended | Children's Hospital Medical Center, Cincinnati | 33 | 2023-03-01 | 2026-10-22 |
| Vorinostat and Combination Chemotherapy Before Donor Stem Cell Transplantation for the Treatment of Relapsed Aggressive B-cell or T-cell Non-Hodgkin Lymphoma Allogeneic Hematopoietic Stem Cell Transplantation, Busulfan, Clofarabine - Recurrent Aggressive Non-Hodgkin Lymphoma, Recurrent B-Cell Non-Hodgkin Lymphoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2021-10-29 | 2024-01-12 | |
| Pembrolizumab and Tamoxifen With or Without Vorinostat for the Treatment of Estrogen Receptor Positive Breast Cancer Pembrolizumab, Tamoxifen, Vorinostat - Anatomic Stage IV Breast Cancer AJCC v8, Prognostic Stage IV Breast Cancer AJCC v8 | Phase 2 | Terminated | University of California, San Francisco | 1 | 2021-03-11 | 2023-08-31 |
| Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations pembrolizumab; vorinostat - Squamous Cell Lung Cancer, Vulvar Cancer | Phase 2 | Completed | UNICANCER | 112 | 2020-10-28 | 2025-02-19 |
| Investigating the Specificity of Neural Correlates for Emotion Processing Deficits in Conduct Disorder and Autism Spectrum Disorders neuroimaging session (with simultaneously acquired eye-tracking), Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ)), Social and Health Assessment (SAHA) questionnaire (for children) - Autism-Spectrum Disorder, Conduct Disorder | Unknown | University Hospital, Basel, Switzerland | 120 | 2020-07-16 | 2022-03-02 | |
| Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial Abemaciclib, Abiraterone, Afatinib - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2020-04-01 | 2024-03-04 |
| Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine) - Hematologic Diseases, Acute Leukemia in Remission | Phase 1 / Phase 2 | Active not recruiting | University of Michigan Rogel Cancer Center | 43 | 2020-02-04 | 2026-01-27 |
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Leukemia, Myeloid, Acute (28) · Lymphoma (26) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (24) · Breast Neoplasms (22) · Carcinoma, Non-Small-Cell Lung (21) · Lymphoma, Large B-Cell, Diffuse (21) · Multiple Myeloma (21) · Lymphoma, Non-Hodgkin (19) · Lymphoma, Mantle-Cell (17) · Lymphoma, Follicular (16) · Hodgkin Disease (15) · Myelodysplastic Syndromes (15) · Glioblastoma (13) · Lymphoma, T-Cell, Cutaneous (13) · Brain Neoplasms (12)
National Cancer Institute (NCI) (63) · Merck Sharp & Dohme LLC (26) · M.D. Anderson Cancer Center (20) · University of Washington (6) · City of Hope Medical Center (5) · Fred Hutchinson Cancer Center (5) · Masonic Cancer Center, University of Minnesota (5) · University of North Carolina, Chapel Hill (5) · H. Lee Moffitt Cancer Center and Research Institute (4) · Memorial Sloan Kettering Cancer Center (4) · New Approaches to Neuroblastoma Therapy Consortium (4) · Ohio State University Comprehensive Cancer Center (3) · Roswell Park Cancer Institute (3) · St. Jude Children's Research Hospital (3) · University of California, San Francisco (3)
United States (201) · Canada (19) · Australia (10) · France (6) · United Kingdom (6) · Germany (5) · Italy (5) · Denmark (3) · Japan (3) · Netherlands (3) · South Korea (3) · Spain (3) · Austria (2) · Colombia (2) · Singapore (2)
Evanthia Galanis (3) · Michael Burke, MD (3) · Chandra P Belani, MD (2) · David Margolis, MD (2) · Guillermo Garcia-Manero (2) · Hamid Sayar, MD (2) · Hannah Linden (2) · Leona Holmberg (2) · Leslie Popplewell (2) · Maryam Fouladi (2) · Neal I Muni, M.D., MSPH (2) · Pamela Munster, MD (2) · Pavan Reddy, MD (2)
PMID 34389161, PMID 39863139, PMID 32632956, PMID 17145826, PMID 18297527, PMID 18854394, PMID 19213682, PMID 19590405, PMID 19794082, PMID 19817748, PMID 19834480, PMID 19887475, PMID 19951879, PMID 20378407, PMID 21300924, PMID 21473790, PMID 22082325, PMID 22133771, PMID 22200869, PMID 22234637, PMID 22239668, PMID 22472858, PMID 22506596, PMID 22836995, PMID 22837004, PMID 22915450, PMID 22952756, PMID 22999944, PMID 23040438, PMID 23233571, PMID 23516360, PMID 23554030, PMID 23660685, PMID 23913470, PMID 23953882, PMID 24055414, PMID 24142996, PMID 24295572, PMID 24464266, PMID 24562384, PMID 24617454, PMID 24620025, PMID 24636848, PMID 24891274, PMID 25040094, PMID 25055291, PMID 25213183, PMID 25393648, PMID 25476537, PMID 25596263
N01CM62209 (6), P30CA015704 (6), P30CA033572 (6), N01CM62204 (5), U01CA062491 (5), U01CA062505 (5), 2008 (4), N01CM62205 (4), P30CA006973 (4), U10CA032102 (4), N01CM00100 (3), N01CM62201 (3), N01CM62206 (3), N01CM62208 (3), P30CA008748 (3)