47 completed, 18 unknown, 8 recruiting, 3 active not recruiting. 51 Not applicable, 3 Phase 2, 3 Phase 3, 2 Phase 1, 2 Phase 4.
Follow Spasticity, Muscle: new trials by email Literature Review of Spasticity, Muscle trials Research Report on Spasticity, Muscle
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury Vibrotactile Coordinated Reset - Spasticity, Muscle, Spinal Cord Injuries | Not applicable | Not yet recruiting | Stanford University | 30 | 2026-03-15 | 2025-05-15 |
| How Stroke Affects Leg Muscles When Walking Stroke, Physical Inactivity | Completed | University Hospital, Limoges | 500 | 2025-08-19 | 2026-04-01 | |
| Investigation of the Effects of Upper Extremity Botulinum Toxin Application on Forearm Muscle Thickness and Motor Recovery in Patients With Hemiplegia Botulinum toxin application - Hemiplegia, Spasticity, Muscle | Completed | Abant Izzet Baysal University | 20 | 2025-07-13 | 2025-07-24 | |
| Effect of Transcutaneous Auricular Nerve Stimulation vs Body Rocking Exercises on Spasticity of Upper Limb TANS Group, Body Rocking Exercise - Spasticity, Muscle | Not applicable | Active not recruiting | Superior University | 42 | 2025-03-20 | 2025-04-06 |
| Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury Blood sampling - Spinal Cord Injury, Spasticity, Muscle | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 40 | 2024-10-01 | 2024-08-01 |
| FlexWave Trial: Efficacy of Extracorporeal Shock Wave Therapy in Post-Stroke Upper Limb Spasticity focused extracorporeal shock wave therapy (ESWT) - Stroke, Spasticity, Muscle | Not applicable | Active not recruiting | National Taiwan University Hospital | 40 | 2024-03-22 | 2026-10-20 |
| Analysis of the Correlation Between Ultrasound Imaging and Functional Parameters in the Medial Gastrocnemius Muscle in Post-stroke Patients With Spasticity in the Lower Limb Ultrasound imaging and functional assessment - Stroke, Spasticity, Muscle | Completed | Universidad de Zaragoza | 52 | 2024-02-27 | 2025-05-22 | |
| Study of Brain-spinal Cord Neural Connectivity in Spasticity intraoperative neuroelectrophysiological monitoring - Spasticity, Muscle | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 50 | 2024-02-26 | 2025-06-11 | |
| Investıgatıon Of The Effectıveness Of The Mollıı Suıt In Chıldren Wıth Ambulatory Cerebral Palsy EXOPULSE Mollii Suit - Cerebral Palsy, Spasticity, Muscle | Not applicable | Recruiting | Kastamonu University | 32 | 2023-11-05 | 2025-07-11 |
| EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE 2) EXOPULSE Mollii Suit Stimulation - Stroke, Spasticity, Muscle | Not applicable | Unknown | Sheikh Shakhbout Medical City | 36 | 2023-10-24 | 2024-01-22 |
| Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation, Sham - Spasticity as Sequela of Stroke, Spastic Cerebral Palsy | Not applicable | Recruiting | Ohio State University | 22 | 2023-10-12 | 2025-12-19 |
| Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning Spinal Reflex Operant Down Conditioning - Spinal Cord Injuries, Neurological Injury | Not applicable | Recruiting | Medical University of South Carolina | 25 | 2023-08-23 | 2026-09-15 |
| The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity Botulinum toxin type A, %0,9 NaCl - Cerebrovascular Disorders, Spasticity, Muscle | Phase 4 | Withdrawn | Sisli Hamidiye Etfal Training and Research Hospital | 2023-05-25 | 2023-11-22 | |
| EXOPULSE Mollii Suit, Spasticity, Muscular Oxygenation & Multiple Sclerosis (ENNOX 2) EXOPULSE Mollii Suit Stimulation - Sclerosis, Multiple, MS (Multiple Sclerosis) | Not applicable | Unknown | Sheikh Shakhbout Medical City | 36 | 2023-05-18 | 2024-01-18 |
| EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP 2) EXOPULSE Mollii Suit Stimulation - Sclerosis, Multiple, MS (Multiple Sclerosis) | Not applicable | Unknown | Sheikh Shakhbout Medical City | 36 | 2023-03-21 | 2024-04-17 |
| Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) MELPIDA - Spasticity, Muscle, Microcephaly | Phase 1 / Phase 2 | Recruiting | Elpida Therapeutics SPC | 4 | 2023-02-15 | 2026-07-08 |
| Effect of Cryoneurolysis on Pain in Patients With Hand Contracture. Contracture, Spasticity, Muscle | Unknown | Vancouver Island Health Authority | 25 | 2023-01-09 | 2023-10-03 | |
| Effects of PNF and Static Stretching on Architecture and Viscoelastic Properties of Hemiplegic Elbow Exercise, PNF Stretching, Prolonged Stretching - Stroke, Spasticity, Muscle | Not applicable | Completed | Istanbul University - Cerrahpasa | 34 | 2022-11-14 | 2024-06-28 |
| REHABOTICS: Integrated Rehabilitation System for People With Motor Disabilities Rehabotics Physiotherapy, Traditional Physiotherapy - Stroke, Spasticity, Muscle | Not applicable | Completed | Pantelis Syringas | 60 | 2022-11-04 | 2024-07-25 |
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Muscle Spasticity (86) · Stroke (27) · Spinal Cord Injuries (13) · Multiple Sclerosis (9) · Cerebral Palsy (8) · Muscle Hypertonia (6) · Musculoskeletal Diseases (4) · Neurologic Manifestations (4) · Pain (4) · Brain Injuries (3) · Gait Disorders, Neurologic (3) · Hemiplegia (3) · Muscular Diseases (3) · Nervous System Diseases (3) · Neuromuscular Manifestations (3)
Pathological Conditions, Signs and Symptoms (86) · Muscular Diseases (83) · Nervous System Diseases (83) · Neuromuscular Manifestations (83) · Signs and Symptoms (83) · Musculoskeletal Diseases (82) · Neurologic Manifestations (82) · Muscle Hypertonia (80) · Central Nervous System Diseases (54) · Brain Diseases (41) · Cardiovascular Diseases (28) · Vascular Diseases (28) · Cerebrovascular Disorders (27) · Wounds and Injuries (16) · Spinal Cord Diseases (13)
Dry Needling (5) · Botulinum Toxins, Type A (4) · Extracorporeal Shockwave Therapy (3) · Exercise (2) · Neurologic Examination (2) · Rehabilitation (2) · Transcranial Direct Current Stimulation (2) · abobotulinumtoxinA (2) · arbaclofen placarbil (2) · Aftercare (1) · Baclofen (1) · Blood Specimen Collection (1) · Botulinum Toxins (1) · Cardiac Resynchronization Therapy Devices (1) · Control Groups (1)
Medical University of South Carolina (3) · Otivio AS (3) · Sheikh Shakhbout Medical City (3) · Vanderbilt University Medical Center (3) · Copenhagen University Hospital, Rigshospitalet (2) · Guadarrama Hospital (2) · National Taiwan University Hospital (2) · RVL Pharmaceuticals, Inc. (2) · Rizky Kusuma Wardhani (2) · Shepherd Center, Atlanta GA (2) · Universitat Internacional de Catalunya (2) · University of Alberta (2) · Vancouver Island Health Authority (2) · Abant Izzet Baysal University (1) · Alexandria University (1)
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David Charles, M.D. (3) · David Jacobs, MD (2) · Kjell-Morten Myhr, MD, PhD (2) · Peter Vestergaard Rasmussen, MD, PhD (2) · Sara Haghighi Mobarhan Smith, MD, PhD (2) · Aiko K Thompson, PhD (1) · Aiko Thompson, PhD (1) · Anastasia Vishnevetsky, MD, PhD (1) · Angela Frotzler (1) · Athena F Zuppa, MD MSCE (1) · Bo BS Biering-Soerensen, Doctor (1) · Brigitte Perrouin-Verbe, PU-PH (1) · Darius Ebrahimi-Fakhari, MD, PhD (1) · Derek J Curtis, phd (1)
PMID 14506719, PMID 17209981, PMID 17370477, PMID 19083678, PMID 19480872, PMID 21530725, PMID 21729249, PMID 23090951, PMID 23319485, PMID 25530960, PMID 27504139, PMID 27679870, PMID 31215234, PMID 31710277, PMID 31899073, PMID 32778118, PMID 32990858, PMID 33193052, PMID 34721255, PMID 34726763, PMID 36861013, PMID 37130111, PMID 38957349, PMID 40397864, PMID 41491634, PMID 41499331, PMID 42327806, PMID 42455218, PMID 7192811
P20GM109040 (1), R01NS114279 (1), U44NS114420 (1)