7 completed. 7 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Shock, Hemorrhagic: new trials by email Literature Review of Shock, Hemorrhagic trials Research Report on Shock, Hemorrhagic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cold Stored Platelet in Hemorrhagic Shock Cold Stored Platelets (CSP), Standard Care - Trauma, Hemorrhage | Phase 2 | Completed | Jason Sperry | 200 | 2022-06-21 | 2024-12-18 |
| Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma 0.9% Sodium Chloride 250 mL bolus, 0.9% Sodium Chloride 2000 mL bolus - Blunt Trauma, Penetrating Wound | Phase 2 | Completed | University of Washington | 192 | 2012-03-01 | 2015-01-13 |
| Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Saline - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 348 | 2011-05-01 | 2013-08-22 |
| Vasopressin in Traumatic Hemorrhagic Shock Study Vasopressin, Saline placebo - Shock, Hypovolemia | Phase 2 / Phase 3 | Completed | Volker Wenzel | 64 | 2010-07-01 | 2014-11-05 |
| Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Ringers Lactate solution - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 51 | 2009-12-01 | 2013-08-19 |
| The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) Massive transfusion protocol, Standard of care - Hemorrhagic Shock, Trauma Coagulopathy | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 70 | 2009-07-01 | 2011-12-02 |
| Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock) Premarin IV, Placebo - Hemorrhagic Shock | Phase 2 | Completed | University of Texas Southwestern Medical Center | 50 | 2009-07-01 | 2020-03-19 |
Wounds and Injuries (5) · Hemorrhage (3) · Acidosis, Lactic (2) · Shock, Traumatic (2) · Diabetes Insipidus (1) · Hemostatic Disorders (1) · Hypovolemia (1) · Shock (1) · Wounds, Nonpenetrating (1) · Wounds, Penetrating (1)
Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Shock (6) · Hemorrhage (4) · Acid-Base Imbalance (2) · Acidosis (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Cardiovascular Diseases (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1) · Hemorrhagic Disorders (1)
Sodium Chloride (3) · PEG-hemoglobin (2) · Saline Solution (2) · Standard of Care (2) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (2) · Ringer's Lactate (1) · Vasopressins (1) · polynitroxylated pegylated hemoglobin (1)
Sangart (2) · Jason Sperry (1) · Sunnybrook Health Sciences Centre (1) · University of Texas Southwestern Medical Center (1) · University of Washington (1) · Volker Wenzel (1)
Germany (3) · United States (3) · Austria (2) · Canada (2) · France (2) · South Africa (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Colombia (1) · Israel (1) · New Zealand (1) · Norway (1) · Singapore (1) · Spain (1)
Karim Brohi, MD (2) · David Hoyt, MD (1) · Frank Guyette, MD, MPH (1) · Gordon D Rubenfeld, MD, MSc (1) · Homer C Tien, MD, MSc (1) · Jason Sperry, MD, MPH (1) · Myron L Weisfeldt, MD (1) · Prof. Dr. Volker Wenzel, M.Sc., M.D. (1) · Rob Schmickers (1) · Sandro B Rizoli, MD PhD (1)
PMID 22071998, PMID 23857856, PMID 25947955, PMID 38708880
U01HL077863 (1)