7 recruiting, 4 completed, 4 unknown, 2 not yet recruiting. 3 Phase 4, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3 | Recruiting 2, Not yet recruiting 1 |
| Not applicable | 2 | Terminated 1, Unknown 1 |
Follow Severe Infection: new trials by email Literature Review of Severe Infection trials Research Report on Severe Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine N-Acetylcysteine (NAC) Treatment - Sepsis, Acute Infection | Phase 4 | Recruiting | Theis S. Itenov | 360 | 2026-09-07 | 2026-09-16 |
| Infectious Complications in Hematological Patients Under Treatment With Bispecific Antibodies. Lymphoma Neoplasms, Myeloma Multiple | Recruiting | Infanta Leonor University Hospital | 350 | 2026-05-14 | 2026-05-27 | |
| Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators Sepsis, Severe Infection | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 300 | 2026-01-15 | 2026-01-21 | |
| CONTinuous Infusion Versus Intermittent Dosing of ceftaZidime/AVIbactam in Critically Ill Patients Continuos ceftazidime/avibactam infusion, Intermitent dosing as per SMPC - Severe Infection | Phase 4 | Not yet recruiting | Ivan Šitum, MD | 140 | 2025-05-01 | 2025-04-22 |
| CommunautAry Pediatric bacteRial Infection in Intensive CarE Unit Hospitalized Children, Severe Infection | Recruiting | Association Clinique Thérapeutique Infantile du val de Marne | 3000 | 2024-01-01 | 2026-03-19 | |
| Chinese PICU Collaborative Network on Pathogens and Drug Resistance of Severe Infections Severe Infection | Recruiting | Children's Hospital of Fudan University | 2000 | 2023-12-31 | 2026-02-17 | |
| Systematic Screening for Primary Immunodeficiencies in Patients Admitted for Severe Infection in Pediatric Intensive Care Unit Severe Infection, Severe Immune Deficiency | Unknown | University Hospital, Montpellier | 100 | 2023-09-04 | 2024-03-29 | |
| PHAGEinLYON Clinic Cohort Study: a Descriptive Study of Severe Infections Treated With Phage Therapy at the HCL. Description of severe infection - Severe Infection | Recruiting | Hospices Civils de Lyon | 250 | 2023-02-01 | 2023-12-29 | |
| Invasive Group A Streptococcal Infection Sepsis Due to Streptococcus, Group A, Risk Factors | Unknown | Association Clinique Thérapeutique Infantile du val de Marne | 100 | 2022-09-01 | 2024-02-08 | |
| Phage Safety Cohort Study Adverse event after injection of phages - Prosthetic Joint Infection, Severe Infection | Recruiting | Hospices Civils de Lyon | 100 | 2022-05-09 | 2023-04-13 | |
| Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections Duration of therapy - Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection | Not applicable | Terminated | Hospital Moinhos de Vento | 107 | 2022-01-27 | 2024-03-06 |
| Nutritional Supplement for Patients With Severe Infection Lauric Acid and Berberine - Severe Infection | Not applicable | Unknown | University of British Columbia | 48 | 2021-10-01 | 2022-11-02 |
| Clinical Study of Individualized Vancomycin Dosing Based on Population PK Model individualized vancomycin dosing based on the population pharmacokinetics (PK) model, empirical vancomycin dosing - Severe Infection | Phase 4 | Recruiting | Central South University | 112 | 2021-01-01 | 2023-12-08 |
| Evaluation of MDW for Early Detection of Sepsis, Clinical Validity CBC-DIFF with MDW, PCT, CRP - Severe Infection, Sepsis | Completed | Beckman Coulter, Inc. | 947 | 2018-08-08 | 2019-11-22 | |
| Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients Severe Infection | Completed | Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia | 2125 | 2018-01-01 | 2020-11-09 | |
| Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis CBC-Diff Monocyte volume width distribution (MDW) - Sepsis, Severe Infection | Completed | Beckman Coulter, Inc. | 3000 | 2017-06-19 | 2019-11-22 | |
| Evaluation of Pharmacokinetic / Pharmacodynamic Data and Interest Individualized Therapeutic Drug Monitoring Glycopeptides and β-lactam-aminoglycoside ICU Drug Monitoring - Severe Infection | Unknown | Fondation Hôpital Saint-Joseph | 172 | 2015-11-08 | 2023-04-27 | |
| Construction and Validation of a Tool for Automatic Identification of Care Pathways At Risk of Sub-optimality in the Management of Severe Infections in Children (DIABACT IV) Severe Infection | Completed | Nantes University Hospital | 524 | 2015-03-20 | 2024-12-10 |
Infections (18) · Sepsis (6) · Critical Illness (2) · Pseudomonas Infections (2) · Acinetobacter Infections (1) · Bacteremia (1) · Dyslipidemias (1) · Gram-Negative Bacterial Infections (1) · Immunologic Deficiency Syndromes (1) · Liver Diseases (1) · Multiple Myeloma (1) · Multiple Organ Failure (1) · Sprains and Strains (1) · Systemic Inflammatory Response Syndrome (1)
Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Inflammation (6) · Systemic Inflammatory Response Syndrome (5) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Disease Attributes (2) · Immune System Diseases (2) · Shock (2) · Blood Protein Disorders (1) · Cardiovascular Diseases (1) · Digestive System Diseases (1) · Gram-Negative Bacterial Infections (1) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1)
Acetylcysteine (1) · Berberine (1) · Duration of Therapy (1) · Models, Biological (1) · Prescription Drug Monitoring Programs (1) · Therapeutics (1) · lauric acid (1)
Association Clinique Thérapeutique Infantile du val de Marne (2) · Beckman Coulter, Inc. (2) · Hospices Civils de Lyon (2) · Central South University (1) · Children's Hospital of Fudan University (1) · Fondation Hôpital Saint-Joseph (1) · Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia (1) · Hospital Moinhos de Vento (1) · Infanta Leonor University Hospital (1) · Ivan Šitum, MD (1) · Nantes University Hospital (1) · Second Affiliated Hospital of Wenzhou Medical University (1) · Theis S. Itenov (1) · University Hospital, Montpellier (1) · University of British Columbia (1)
France (8) · China (2) · Spain (2) · Brazil (1) · Canada (1) · Colombia (1) · Denmark (1) · United States (1)
Corinne Levy (2) · Alexandre Prehn Zavascki (1) · Camille Brehin (1) · Guoping Lu, Doctor (1) · Hainan Zhang, Doctor (1) · Lionel Berthomieu (1) · Michael Levy (1) · Philippart Francois, MD (1) · Pierre Hausfater, MD (1) · Yves Gillet (1)
PMID 32391157, PMID 34193208, PMID 38102448, PMID 39695798, PMID 40852616, PMID 42428502