5 completed, 5 recruiting, 3 unknown, 2 not yet recruiting. 6 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 2, Recruiting 2, Unknown 2 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow SCD: new trials by email Literature Review of SCD trials Research Report on SCD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis Sodium Chloride (NaCl) 0.9 % - SCD, Vaso Occlussive Crisis | Not applicable | Recruiting | Imam Abdulrahman Bin Faisal University | 394 | 2025-10-05 | 2026-03-18 |
| Neonatal Screening for Haemoglobinopathies EmoCamp SCD | Not yet recruiting | Maddalena Casale | 1000 | 2025-06-01 | 2025-06-08 | |
| Acute Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity Oral ketone monoester (KME) - MCI, SCD | Not applicable | Completed | University Department of Geriatric Medicine FELIX PLATTER | 15 | 2025-04-12 | 2026-05-18 |
| The Relationship of Platelet Counts With Sickle Cell Anemia in the Eastern Region of Saudi Arabia Platelets count - Sickle Cell Anaemia, SCD | Not yet recruiting | Majmaah University | 650 | 2024-12-01 | 2024-10-04 | |
| The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD) social isolation - Social Isolation, SCD | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 209 | 2024-03-01 | 2024-03-28 | |
| Effect of Virtual Reality on Pain and Function in Children With Sickle Cell Disease: A Randomized Controlled Trial virtual reality - SCD | Not applicable | Completed | Afnan Bkri | 40 | 2023-09-01 | 2025-06-18 |
| Effects and Mechanism of the Fully Immersive Virtual Reality Cognitive Training Based on Leisure Activities VR cognitive training, Traditional cognitive training - MCI, SCD | Not applicable | Unknown | Chang Gung Memorial Hospital | 275 | 2023-01-01 | 2023-01-12 |
| The Swedish BioFINDER - Memory Clinic Study Plasma Amyloid Probability Score 2 (APS 2) score, Plasma ptau217/nptau217, Plasma ptau217 - Mild Dementia, Mild Cognitive Impairment | Recruiting | Skane University Hospital | 1200 | 2022-12-01 | 2026-04-06 | |
| Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD) Non-Invasive Infrared Spectroscopy - SCD | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 49 | 2022-11-28 | 2025-08-01 | |
| Identification of Neuroinflammation and Neuroimaging Biomarkers Through Data Driven Artificial Intelligence Techniques for Unraveling the Heterogeneity of Aged Subjects at Risk of Dementia and to Better Inform Prevention Strategies Multidomain cognitive training and physical training - MCI, SCD | Not applicable | Recruiting | IRCCS Fondazione Stella Maris | 115 | 2022-02-01 | 2024-12-24 |
| Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and SCD. VR cognitive training, Traditional cognitive training - MCI, SCD | Not applicable | Unknown | Chang Gung Memorial Hospital | 190 | 2021-10-01 | 2021-05-17 |
| The Swedish BioFINDER - Primary Care Study Plasma APS 2 score, Plasma p-tau217/np-tau217, Plasma p-tau217 - Mild Dementia, Mild Cognitive Impairment | Recruiting | Skane University Hospital | 1200 | 2020-01-01 | 2026-04-06 | |
| Early Check: Expanded Screening in Newborns Confirmatory Testing - Spinal Muscular Atrophy, Fragile X Syndrome | Active not recruiting | RTI International | 30000 | 2018-10-15 | 2026-07-01 | |
| High Dose Omega 3 in People at Risk for Dementia Omega-3 capsules, Olive oil - Dementia, Inflammation | Phase 2 | Unknown | University Hospital, Akershus | 40 | 2018-10-01 | 2019-04-24 |
| Hematopoietic Stem Cell Transplant for Sickle Cell Disease Fludarabine, Hematopoietic Stem Cell Transplant (HSCT) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Case Comprehensive Cancer Center | 4 | 2015-10-19 | 2024-04-29 |
| A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) KPS-0373, Placebo - SCD | Phase 2 | Completed | Kissei Pharmaceutical Co., Ltd. | 200 | 2012-12-03 |
Anemia, Sickle Cell (5) · Cognitive Dysfunction (5) · Alzheimer Disease (3) · Dementia, Vascular (2) · Disease (2) · Lewy Body Disease (2) · 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (1) · 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (1) · 3-methylcrotonyl CoA carboxylase 1 deficiency (1) · 3-methylcrotonyl CoA carboxylase 2 deficiency (1) · Acidemia, isovaleric (1) · Acrodermatitis enteropathica (1) · Adenine phosphoribosyltransferase deficiency (1) · Adrenal hyperplasia, congenital, type 5 (1) · Adrenocorticotropic hormone deficiency (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Genetic Diseases, Inborn (6) · Anemia (5) · Anemia, Hemolytic (5) · Anemia, Hemolytic, Congenital (5) · Brain Diseases (5) · Central Nervous System Diseases (5) · Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Hemoglobinopathies (5) · Mental Disorders (5) · Nervous System Diseases (5) · Neurodegenerative Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Cognition Disorders (4)
Docosahexaenoic Acids (1) · Magnetic Resonance Imaging (1) · Olive Oil (1) · Platelet Count (1) · Sodium Chloride (1) · Stem Cell Transplantation (1) · fludarabine (1) · fludarabine phosphate (1)
Chang Gung Memorial Hospital (2) · Skane University Hospital (2) · Afnan Bkri (1) · Case Comprehensive Cancer Center (1) · IRCCS Fondazione Stella Maris (1) · Imam Abdulrahman Bin Faisal University (1) · Kissei Pharmaceutical Co., Ltd. (1) · Maddalena Casale (1) · Majmaah University (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · RTI International (1) · The First Affiliated Hospital with Nanjing Medical University (1) · University Department of Geriatric Medicine FELIX PLATTER (1) · University Hospital, Akershus (1)
Saudi Arabia (3) · United States (3) · Italy (2) · Sweden (2) · China (1) · Japan (1) · Norway (1) · Switzerland (1) · Taiwan (1)
Erik Stomrud, MD, PhD (2) · Curt Scharfe, MD, PhD (1) · I-Ching Chuan, Ph.D (1) · Katsumi Hontani (1) · Khalid A Majrashi (1) · Maddalena Casale, Professor (1) · Mohammed S Alshahrani, MD (1) · Molly Gallogly, MD, PhD (1) · Sabine Krumm, PD, PhD (1) · Swee Lay Thein, M.D. (1) · Tormod Fladby, MD PhD (1) · Zhu Yi (1)
PMID 30186009, PMID 31315600, PMID 33489197, PMID 35142618, PMID 41664928, PMID 9531343