12 completed, 5 recruiting, 1 active not recruiting. 3 Early Phase 1, 3 Not applicable, 3 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 3 | Active not recruiting 1, Completed 1, Recruiting 1 |
| Not applicable | 3 | Completed 2, Recruiting 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Retinoschisis: new trials by email Literature Review of Retinoschisis trials Research Report on Retinoschisis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD) Retinitis Pigmentosa, Stargardt Macular Dystrophy | Recruiting | Ray Therapeutics, Inc. | 25 | 2026-02-19 | 2026-03-31 | |
| Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis IVB102 Injection - Retinoschisis, Retinal Disease | Early Phase 1 | Active not recruiting | InnoVec Biotherapeutics Inc. | 18 | 2024-03-08 | 2026-11-04 |
| Safety and Efficacy of a Single Subretinal Injection of JWK002 Gene Therapy in Subjects With X-linked Retinoschisis(XLRS) JWK002 - X Linked Retinoschisis | Early Phase 1 | Recruiting | West China Hospital | 12 | 2023-11-17 | 2025-02-07 |
| ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis ATSN-201 - X-linked Retinoschisis | Phase 3 | Recruiting | Atsena Therapeutics Inc. | 97 | 2023-08-22 | 2026-09-29 |
| The AXIS Study: the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in Retinoschisis Acetazolamide - Retinoschisis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 19 | 2023-01-20 | 2025-05-31 |
| Safety and Efficacy Study of LX103 Treatment of X-Linked Retinoschisis (XLRS) LX103 Injection - X-linked Retinoschisis | Not applicable | Recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 12 | 2022-12-13 | 2023-04-18 |
| Safety and Efficacy Study of Novel Gene Therapy ZM-01 for X-linked Retinoschisis Patients ZM-01-L, ZM-01-H - X-linked Retinoschisis | Early Phase 1 | Completed | Zhongmou Therapeutics | 2 | 2022-09-25 | 2026-03-31 |
| Mothers Experiences With X-linked Retinoschisis Compared to Fathers Experiences Retinoschisis, X-Linked | Completed | National Eye Institute (NEI) | 12 | 2017-12-01 | 2019-11-01 | |
| Safety and Efficacy of rAAV-hRS1 in Patients With X-linked Retinoschisis (XLRS) rAAV2tYF-CB-hRS1 - X-linked Retinoschisis | Phase 1 / Phase 2 | Completed | Beacon Therapeutics | 27 | 2015-05-01 | 2023-06-12 |
| Effects of Macular Buckle Versus Vitrectomy on Macular Schisis and Macular Detachment in Highly Myopic Eyes Macular buckling, Vitrectomy - Retinoschisis, Macular Detachment | Not applicable | Completed | Sun Yat-sen University | 80 | 2015-04-01 | 2017-10-16 |
| Study of RS1 Ocular Gene Transfer for X-linked Retinoschisis RS1 AAV Vector - Retinoschisis, X-Linked | Phase 1 / Phase 2 | Completed | VegaVect, Inc. | 12 | 2015-02-11 | 2025-02-14 |
| People s Expectations When Enrolling in a Phase I/II RS1 Ocular Gene Transfer Clinical Trial Retinoschisis, X-Linked | Completed | National Eye Institute (NEI) | 13 | 2014-12-13 | 2019-12-09 | |
| Inherited Retinal Degenerative Disease Registry Eye Diseases Hereditary, Retinal Disease | Recruiting | Foundation Fighting Blindness | 20000 | 2014-06-01 | 2026-05-19 | |
| Optical Coherence Tomography Evaluation of Retinoschisis and Retinal Detachment Retinoschisis | Completed | Medical University of Vienna | 44 | 2013-09-01 | 2016-08-08 | |
| Clinical Evaluation of Patients With X-linked Retinoschisis Dorzolamide 2% TID or brinzolamide 1% TID - X-linked Retinoschisis, XLRS | Completed | Beacon Therapeutics | 66 | 2012-11-01 | 2017-11-17 | |
| Postoperative Pain Control Following Vitreoretinal Surgery Triamcinolone, Bupivicaine Hydrochloride - Retinal Detachment, Proliferative Vitreoretinopathy | Phase 4 | Completed | Emory University | 58 | 2012-07-01 | 2017-03-21 |
| Vitrectomy for Optic Disc Pit Maculopathy vitrectomy without laser or gas tamponade - Optic Disc Pit Maculopathy | Not applicable | Completed | Kyorin University | 8 | 2005-01-01 | 2011-04-22 |
| Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis Retinoschisis | Completed | National Eye Institute (NEI) | 351 | 2003-05-19 | 2026-11-09 |
Retinal Degeneration (2) · Retinal Detachment (2) · Retinal Diseases (2) · Retinitis Pigmentosa (2) · Stargardt Disease (2) · Abetalipoproteinemia (1) · Achromatopsia 3 (1) · Bardet-Biedl Syndrome (1) · Charcot-Marie-Tooth Disease (1) · Choroideremia (1) · Color Vision Defects (1) · Cone Dystrophy (1) · Cone-Rod Dystrophies (1) · Enhanced S-Cone Syndrome (1)
Eye Diseases (17) · Retinal Degeneration (16) · Retinal Diseases (16) · Eye Diseases, Hereditary (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Macular Degeneration (2) · Abnormalities, Multiple (1) · Blindness (1) · Brain Diseases (1) · Brain Diseases, Metabolic (1) · Brain Diseases, Metabolic, Inborn (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1)
Vitrectomy (2) · Acetazolamide (1) · Bupivacaine (1) · Lasers (1) · Triamcinolone (1) · Triamcinolone Acetonide (1) · brinzolamide (1) · dorzolamide (1)
National Eye Institute (NEI) (3) · Beacon Therapeutics (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Atsena Therapeutics Inc. (1) · Emory University (1) · Foundation Fighting Blindness (1) · InnoVec Biotherapeutics Inc. (1) · Kyorin University (1) · Medical University of Vienna (1) · Ray Therapeutics, Inc. (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1) · Sun Yat-sen University (1) · VegaVect, Inc. (1) · West China Hospital (1) · Zhongmou Therapeutics (1)
United States (10) · China (5) · Austria (1) · Canada (1) · Japan (1) · Netherlands (1) · United Kingdom (1)
Amy E Turriff (2) · Laryssa A Huryn, M.D. (2) · Akito Hirakata, MD (1) · Camiel JF Boon, Prof. dr. (1) · Fang Lu (1) · Lin Lu, MD，PhD (1) · Matt Feinsod, MD (1) · Theresa Heah, MD (1) · Timothy W Olsen, MD (1) · Todd Durham, PhD (1) · Yin Shen, PhD (1)
PMID 30196853, PMID 30551202, PMID 33601057, PMID 34390869, PMID 36227606