10 completed, 3 active not recruiting, 3 recruiting, 1 unknown. 6 Phase 2, 2 Not applicable, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 6 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome Placebo, NPI-001 - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-10-01 | 2026-10-13 |
| Gyrate Atrophy Ocular and Systemic Study Gyrate Atrophy, Gyrata of Choroid and Retina; Atrophy | Active not recruiting | Jaeb Center for Health Research | 46 | 2023-11-21 | 2026-10-27 | |
| Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants Inherited Retinal Degeneration, Retinitis Pigmentosa | Recruiting | Jaeb Center for Health Research | 1500 | 2023-05-11 | 2026-09-08 | |
| The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study Vitamin A palmitate - Choroideremia | Not applicable | Withdrawn | Duke University | 2023-05-01 | 2023-06-29 | |
| Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F Retinal Degeneration, Retinitis Pigmentosa | Active not recruiting | Jaeb Center for Health Research | 44 | 2021-06-08 | 2026-02-04 | |
| Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome NPI-001, Placebo - Usher Syndromes | Phase 1 / Phase 2 | Completed | Nacuity Pharmaceuticals, Inc. | 49 | 2020-09-03 | 2026-07-01 |
| Rate of Progression in EYS Related Retinal Degeneration Retinitis Pigmentosa, Eye Diseases | Completed | Jaeb Center for Health Research | 103 | 2020-02-25 | 2026-08-05 | |
| Rate of Progression in USH2A-related Retinal Degeneration Usher Syndrome, Type 2A, Retinitis Pigmentosa 39 | Active not recruiting | Jaeb Center for Health Research | 127 | 2017-08-11 | 2026-07-23 | |
| An Open Label Clinical Trial of Retinal Gene Therapy for Choroideremia rAAV2.REP1 vector - Choroideremia | Phase 1 / Phase 2 | Completed | University of Alberta | 6 | 2015-04-01 | 2022-05-19 |
| Inherited Retinal Degenerative Disease Registry Eye Diseases Hereditary, Retinal Disease | Recruiting | Foundation Fighting Blindness | 20000 | 2014-06-01 | 2026-05-19 | |
| Observational Study of the Argus® II Retinal Prosthesis System Retinitis Pigmentosa | Unknown | University Health Network, Toronto | 10 | 2014-04-01 | 2015-04-24 | |
| A Natural History of the Progression of Stargardt Disease: Retrospective and Prospective Studies Stargardt Disease | Completed | Foundation Fighting Blindness | 259 | 2013-08-01 | 2019-11-01 | |
| Clinical Evaluation of Patients With X-linked Retinoschisis Dorzolamide 2% TID or brinzolamide 1% TID - X-linked Retinoschisis, XLRS | Completed | Beacon Therapeutics | 66 | 2012-11-01 | 2017-11-17 | |
| Omega-3 Supplementation and Vitreal VEGF Levels in Wet-AMD Anti-VEGF plus AREDS-2, Anti-VEGF plus AREDS-1 - Exudative Age Related Macular Degeneration | Not applicable | Completed | Maisonneuve-Rosemont Hospital | 40 | 2011-02-01 | 2017-04-24 |
| Trial of Oral Valproic Acid for Retinitis Pigmentosa Valproic Acid, Placebo - Retinitis Pigmentosa | Phase 2 | Completed | Foundation Fighting Blindness | 90 | 2010-11-01 | 2017-12-02 |
| DHA and X-Linked Retinitis Pigmentosa docosahexaenoic acid OR corn/soy oil placebo - Retinitis Pigmentosa, X-linked Genetic Diseases | Phase 2 | Completed | Retina Foundation of the Southwest | 78 | 2004-09-01 | 2015-03-17 |
| Safety Study in Retinal Transplantation for Retinitis Pigmentosa. Retinal transplantation instrument, Fetal tissue. - Retinitis Pigmentosa. | Phase 2 | Completed | Radtke, Norman D., M.D. | 10 | 2002-02-01 | 2012-04-11 |
| Safety Study in Retinal Transplantation for Dry Age Related Macular Degeneration. Retinal transplantation instrument, Fetal tissue. - Dry Age Related Macular Degeneration. | Phase 2 | Completed | Radtke, Norman D., M.D. | 10 | 2002-02-01 | 2014-03-13 |
Retinitis Pigmentosa (9) · Choroideremia (3) · Usher Syndromes (3) · Eye Diseases, Hereditary (2) · Gyrate Atrophy (2) · Retinal Degeneration (2) · Retinoschisis (2) · Stargardt Disease (2) · Abetalipoproteinemia (1) · Achromatopsia 3 (1) · Atrophy (1) · Bardet-Biedl Syndrome (1) · Charcot-Marie-Tooth Disease (1) · Color Vision Defects (1) · Cone Dystrophy (1)
Docosahexaenoic Acids (1) · Fatty Acids, Omega-3 (1) · Valproic Acid (1) · brinzolamide (1) · dorzolamide (1) · retinol palmitate (1)
United States (14) · Canada (8) · France (6) · Germany (5) · United Kingdom (5) · Netherlands (4) · Finland (3) · Israel (3) · Australia (2) · Brazil (2) · Italy (2) · Switzerland (2) · Belgium (1) · Mexico (1) · Norway (1)
Norman D. Radtke, M.D. (2) · David Valle, MD (1) · Dennis R. Hoffman, Ph.D. (1) · Flavio A Rezende, MD, PhD (1) · Hendrik Scholl, MD (1) · Ian M MacDonald, MD, CM (1) · Jacque Duncan, MD (1) · Katarina Stingl, MD (1) · Lee Anderson, MD (1) · Mandeep S. Singh, MD (1) · Mark Pennesi, MD, PhD (1) · Matt Feinsod, MD (1) · Patricia Zilliox, PhD (1) · Robert Devenyi, MD (1)
PMID 10511047, PMID 11931789, PMID 15302656, PMID 18547537, PMID 23828615, PMID 24805262, PMID 25015354, PMID 25342618, PMID 26469750, PMID 26786511, PMID 27378015, PMID 28549516, PMID 29049437, PMID 29879277, PMID 29902293, PMID 30551202, PMID 31269854