11 completed, 6 recruiting, 5 not yet recruiting, 2 terminated. 7 Not applicable, 5 Phase 2, 4 Phase 3, 2 Phase 1.
Follow Retinopathy of Prematurity (ROP): new trials by email Literature Review of Retinopathy of Prematurity (ROP) trials Research Report on Retinopathy of Prematurity (ROP)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system - Retinopathy of Prematurity (ROP) | Not applicable | Recruiting | Duke University | 175 | 2026-12-01 | 2026-09-17 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| HBM-Based Education for Retinopathy of Prematurity Screening in Parents of Premature Infants HBM-Based Video Education, HBM-Based Audio Education, Standard Counselling and Pamphlet - Retinopathy of Prematurity (ROP) | Not applicable | Not yet recruiting | Aga Khan University | 99 | 2026-07-01 | 2026-06-22 |
| Safety, PK and PD of FLQ-101 in Premature Neonates FLQ-101 - Retinopathy of Prematurity (ROP) | Phase 1 | Recruiting | FELIQS INC. | 18 | 2026-04-03 | 2026-10-13 |
| Retinopathy of Prematurity - Visual Function and Retinal Structure Retinopathy of Prematurity (ROP), Prematurity Complications | Not yet recruiting | Oslo University Hospital | 140 | 2026-04-01 | 2026-02-23 | |
| The Correlation Between Red Cell Transfusion and Complications of Prematurity Wechsler Intelligence Test, performed by educated psychologists - Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD) | Recruiting | Clinical Hospital Center Rijeka | 128 | 2025-09-01 | 2026-10-22 | |
| Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity Retinopathy of Prematurity (ROP), ROP Examination | Recruiting | Vanderbilt University Medical Center | 90 | 2025-02-01 | 2026-08-04 | |
| A Multicenter and Prospective Study of Screening Retinopathy of Prematurity in China Premature Birth of Newborn, Retinopathy of Prematurity (ROP) | Completed | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 4841 | 2024-12-03 | 2026-07-31 | |
| Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy Conbercept - Retinopathy of Prematurity (ROP) | Not applicable | Recruiting | Wang Yusheng | 146 | 2024-11-29 | 2026-07-30 |
| Long-term Ophthalmic Outcomes in Ex-premature Infants eye drops (Tropicamid) - Retinopathy of Prematurity (ROP), Premature Birth | Not yet recruiting | Erasmus Medical Center | 210 | 2024-11-01 | 2024-10-18 | |
| The Effect of Two Non-Pharmacological Methods on Pain During Retinopathy Examination Reverse Kangaroo Care Position, ROP Position - Retinopathy of Prematurity (ROP) | Not applicable | Recruiting | Sinem Basdemir | 84 | 2024-02-19 | 2024-11-19 |
| To Assess the Effect of Dexamethasone Eye Drops on the Retinopathy of Prematurity Outcome Dexamethasone eyedrop - Retinopathy of Prematurity (ROP) | Completed | Region Skane | 2017 | 2022-12-01 | 2025-01-22 | |
| Intravitreal Ranibizumab for Aggressive Posterior Retinopathy of Prematurity: A Prospective Interventional Case Series Intravitreal Ranibizumab injection - Retinopathy of Prematurity (ROP) | Not applicable | Completed | Ain Shams University | 39 | 2021-09-10 | 2026-07-23 |
| Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants No Intervention - Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage | Terminated | Oak Hill Bio Ltd | 26 | 2020-09-09 | 2023-03-24 | |
| Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090 Eylea (Aflibercept, BAY86-5321), Laser photocoagulation - Retinopathy of Prematurity (ROP) | Phase 3 | Completed | Bayer | 100 | 2020-03-18 | 2025-10-10 |
| Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy Eylea (Aflibercept, BAY86-5321), Laser photocoagulation - Retinopathy of Prematurity (ROP) | Phase 3 | Completed | Bayer | 113 | 2019-09-25 | 2022-05-06 |
| A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants OHB-607 - Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity | Phase 2 | Active not recruiting | OHB Neonatology Ltd. | 295 | 2019-05-09 | 2026-08-03 |
| Rainbow Extension Study Ranibizumab - Retinopathy of Prematurity (ROP) | Phase 3 | Completed | Novartis Pharmaceuticals | 180 | 2016-06-16 | 2023-02-13 |
| Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study ROPP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP) rhIGF-1/rhIGFBP-3 - Retinopathy of Prematurity (ROP) | Phase 2 | Completed | Shire | 76 | 2015-03-26 | 2022-05-18 |
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Retinopathy of Prematurity (26) · Premature Birth (10) · Bronchopulmonary Dysplasia (5) · Infant, Newborn, Diseases (2) · Retinal Diseases (2) · Agnosia (1) · Anemia, Neonatal (1) · Birth Weight (1) · Blindness, Cortical (1) · Coitus (1) · Enterocolitis, Necrotizing (1) · Eye Diseases (1) · Infant, Premature, Diseases (1) · Neurodevelopmental Disorders (1) · Obstetric Labor Complications (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (26) · Eye Diseases (25) · Infant, Premature, Diseases (25) · Infant, Newborn, Diseases (24) · Retinal Diseases (24) · Female Urogenital Diseases and Pregnancy Complications (11) · Urogenital Diseases (11) · Pregnancy Complications (10) · Obstetric Labor Complications (9) · Obstetric Labor, Premature (9) · Lung Diseases (5) · Lung Injury (5) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Diseases (5) · Ventilator-Induced Lung Injury (5)
Insulin-Like Growth Factor I (3) · Ranibizumab (2) · aflibercept (2) · Cyclopentolate (1) · Fentanyl (1) · Injections (1) · Inositol (1) · KH902 fusion protein (1) · Phenylephrine (1) · Saline Solution (1) · Tomography, Optical Coherence (1)
Bayer (2) · Shire (2) · University Hospital Freiburg (2) · Aga Khan University (1) · Ain Shams University (1) · Alaska Blind Child Discovery (1) · Clinical Hospital Center Rijeka (1) · Duke University (1) · Erasmus Medical Center (1) · FELIQS INC. (1) · Georgetown University (1) · Hospital Clinic of Barcelona (1) · Marsha Campbell-Yeo (1) · NICHD Neonatal Research Network (1) · Novartis Pharmaceuticals (1)
United States (11) · Italy (7) · United Kingdom (7) · Netherlands (6) · Sweden (6) · Germany (4) · Japan (4) · Spain (4) · Turkey (Türkiye) (4) · Belgium (3) · Czechia (3) · Greece (3) · Hungary (3) · Malaysia (3) · Poland (3)
Andreas Stahl, MD (2) · Abbot R Laptook, MD (1) · Abhik Das, PhD (1) · Ahmed Mansour, MD, PhD (1) · Barbara J Stoll, MD (1) · Barbara Schmidt, MD (1) · Carl T D'Angio, MD (1) · Dale L Phelps, MD (1) · Dinara Smarkanova, MD (1) · Edward F Bell, MD (1) · Erlend Christoffer Sommer Landsend, M.D., Ph.D. (1) · Greg Sokol, MD (1)
PMID 23095978, PMID 24069180, PMID 27870826, PMID 28934640, PMID 29309486, PMID 30471715, PMID 31756675, PMID 34391532, PMID 34686832, PMID 35681088, PMID 35881122, PMID 36473425, PMID 38200320, PMID 38638400, PMID 38687481, PMID 41786363, PMID 42458331, PMID 42641311
2018 (3), 2014 (2), 2023 (1), R01EY025009 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD027851 (1), U10HD027853 (1), U10HD027856 (1), U10HD027880 (1), U10HD027904 (1), U10HD034216 (1), U10HD036790 (1), U10HD040492 (1)