7 not yet recruiting, 7 recruiting, 4 completed, 2 terminated. 6 Not applicable, 2 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Not yet recruiting 4, Completed 1, Recruiting 1 |
| Phase 3 | 2 | Terminated 2 |
| Phase 2 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Respiratory Distress Syndrome (RDS): new trials by email Literature Review of Respiratory Distress Syndrome (RDS) trials Research Report on Respiratory Distress Syndrome (RDS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation - Respiratory Distress Syndrome (RDS), Newborn | Not applicable | Not yet recruiting | Aga Khan University | 158 | 2026-10-01 | 2026-09-23 |
| Feasibility of Protocolised Analgosedation in ECMO Sedation protocol - Intensive Care (ICU), Respiratory Distress Syndrome (RDS) | Not applicable | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 60 | 2026-09-01 | 2026-05-12 |
| Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal) | Recruiting | Vastra Gotaland Region | 300 | 2026-05-25 | 2026-08-20 | |
| Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively? Betamethasone - Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD) | Phase 2 | Not yet recruiting | Khang Nguyen | 100 | 2026-04-01 | 2026-03-03 |
| Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome Poractant alfa, Calfactant - Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS) | Phase 4 | Recruiting | Uludag University | 234 | 2026-01-20 | 2026-04-28 |
| Components of Mechanical Power on the Functional Lung in ARDS monitoring of clinical and ventilatory variables - Respiratory Distress Syndrome (RDS) | Not yet recruiting | Ramos Mejía Hospital | 184 | 2025-12-01 | 2025-12-04 | |
| Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol Not an intervention study - Intensive Care Medicine, Respiratory Distress Syndrome (RDS) | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 120 | 2025-11-24 | 2026-05-08 | |
| Using Artificial Intelligence Models for Predicting The Need for Intubation and Successful Weaning From Mechanical Ventilation in ICU Patients Respiratory Distress Syndrome (RDS) | Not yet recruiting | Assiut University | 600 | 2025-10-01 | 2025-07-15 | |
| Breathing Patterns in Infants Before and After Extubation Observation - Respiratory Distress Syndrome (RDS), PreTerm Neonate | Recruiting | Christiana Care Health Services | 30 | 2025-04-14 | 2026-04-21 | |
| Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome. NIPPV, CPAP - Respiratory Distress Syndrome (RDS) | Not applicable | Recruiting | Vilnius University | 150 | 2025-03-25 | 2025-05-13 |
| Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy Neonatologist performed lung ultrasound - PreTerm Neonate, Respiratory Distress Syndrome (RDS) | Not applicable | Not yet recruiting | Royal Hospital For Women | 20 | 2025-03-01 | 2025-03-28 |
| SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome Respiratory Distress Syndrome (RDS), Respiratory Failure | Recruiting | University of Padova | 40 | 2025-02-28 | 2025-03-05 | |
| Study on the Correlation Between Tracheotomy Tip Pressure and Esophageal Pressure in Patients Weaned from Tracheotomy Esophageal pressure monitoring, Tracheotomy tip pressure - Respiratory Distress Syndrome (RDS), Respiratory Ilness | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 42 | 2025-02-05 | 2025-01-20 |
| A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants Video laryngoscopy used to insert thin endotracheal catheter, Direct laryngoscopy used to insert thin endotracheal catheter - Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS) | Recruiting | University College Dublin | 600 | 2025-01-13 | 2025-02-20 | |
| FiO2 Delivered With Neonatal bCPAP Respiratory Distress Syndrome (RDS), Infant, Premature, Diseases | Completed | Karolinska Institutet | 100 | 2024-09-28 | 2025-05-20 | |
| Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns Infant, Premature - Preterm Birth, Low Birth Weight | Completed | HOSPITAL GINECO OBSTETRICO ISIDRO AYORA | 26000 | 2023-11-12 | 2024-10-22 | |
| Nasal High Frequency in Preterm Neonates nasal high frequency oscillatory ventilation mode, nasal continuous positive pressure ventilation mode - Respiratory Distress Syndrome (RDS), Neonatal Diseases and Abnormalities | Not applicable | Completed | Ain Shams University | 90 | 2021-07-15 | 2024-11-13 |
| A Study in Preterm Neonates With Respiratory Distress Syndrome (RDS) Comparing CUROSURF® Administration Through Less Invasive Surfactant Administration (LISA) and Conventional Administration LISA combination product (Curosurf+catheter CHF6440), Curosurf through conventional administration (endotracheal tube) - Respiratory Distress Syndrome (RDS) | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 33 | 2021-05-18 | 2023-11-07 |
| Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours - Premature Birth, Neonatal Hypoglycemia | Completed | Stella Maris Women and Children Hospital | 200 | 2018-01-01 | 2026-08-14 | |
| Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure Inhaled nitric oxide, Placebo - Infant, Newborn, Infant, Low Birth Weight | Phase 3 | Terminated | NICHD Neonatal Research Network | 420 | 2001-01-01 | 2017-09-26 |
Respiratory Distress Syndrome (20) · Premature Birth (6) · Pulmonary Atelectasis (3) · Respiratory Distress Syndrome, Newborn (3) · Agnosia (2) · Dyspnea (2) · Neonatal Sepsis (2) · Shock, Cardiogenic (2) · Abruptio Placentae (1) · Asphyxia Neonatorum (1) · Bronchopulmonary Dysplasia (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Diabetes, Gestational (1) · Enterocolitis, Necrotizing (1)
Lung Diseases (20) · Respiration Disorders (20) · Respiratory Tract Diseases (20) · Pathological Conditions, Signs and Symptoms (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Obstetric Labor Complications (6) · Obstetric Labor, Premature (6) · Pregnancy Complications (6) · Urogenital Diseases (6) · Infant, Newborn, Diseases (5) · Infant, Premature, Diseases (5) · Pathologic Processes (5) · Cardiovascular Diseases (4) · Signs and Symptoms (4)
Betamethasone (1) · Continuous Positive Airway Pressure (1) · Dexamethasone (1) · Observation (1) · calfactant (1) · poractant alfa (1)
Guy's and St Thomas' NHS Foundation Trust (2) · Aga Khan University (1) · Ain Shams University (1) · Assiut University (1) · Chiesi Farmaceutici S.p.A. (1) · Christiana Care Health Services (1) · HOSPITAL GINECO OBSTETRICO ISIDRO AYORA (1) · Karolinska Institutet (1) · Khang Nguyen (1) · NICHD Neonatal Research Network (1) · Ramos Mejía Hospital (1) · Royal Hospital For Women (1) · Shanghai Zhongshan Hospital (1) · Stella Maris Women and Children Hospital (1) · Uludag University (1)
United States (4) · Italy (2) · United Kingdom (2) · Australia (1) · China (1) · Croatia (1) · Czechia (1) · Ecuador (1) · Egypt (1) · Greece (1) · Hungary (1) · Indonesia (1) · Lithuania (1) · Norway (1) · Pakistan (1)
Louise Rose, PhD (2) · Abbot R. Laptook, MD (1) · Ali S Hussain, FCPS (Paeds),FCPS Neonatology (1) · Anders Elfvin, Professor (1) · Charles R. Rosenfeld, MD (1) · Colm P.F. O'Donnell, MB PhD (1) · Dale L. Phelps, MD (1) · Edward F. Donovan, MD (1) · G. Ganesh Konduri, MD (1) · James A. Lemons, MD (1) · Jon E. Tyson, MD MPH (1) · Jordan Kase, MD (1) · Kelley Z Kovatis, MD (1) · Krisa P. Van Meurs, MD (1)
PMID 16000352, PMID 17443204, PMID 17517240, PMID 17586184, PMID 18337740, PMID 19067285
M01RR000032 (1), M01RR000044 (1), M01RR000070 (1), M01RR000633 (1), M01RR000750 (1), M01RR006022 (1), M01RR007122 (1), M01RR008084 (1), M01RR016587 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD027853 (1), U10HD027856 (1), U10HD027871 (1)