25 completed, 18 unknown, 10 recruiting, 4 active not recruiting. 29 Not applicable, 14 Phase 2, 4 Phase 1, 2 Phase 3, 1 Phase 4.
Follow Rectum Cancer: new trials by email Literature Review of Rectum Cancer trials Research Report on Rectum Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial Betacyanin, Pelvic Drainage Fluid Betacyanin Assay - Rectum Cancer, Anastomotic Leak | Not applicable | Not yet recruiting | Southwest Hospital, China | 120 | 2026-08-20 | 2026-07-27 |
| Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery Additional visualisation of surgical assistance during surgery - Rectum Cancer | Not applicable | Recruiting | Technische Universität Dresden | 12 | 2026-02-25 | 2026-08-27 |
| The Effect of Art Therapy in Patients Undergoing Colorectal Cancer Art therapy - Colon Cancer, Rectum Cancer | Not applicable | Active not recruiting | Saglik Bilimleri Universitesi | 96 | 2025-03-01 | 2025-08-22 |
| Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients mFOLFIRINOX, mFolfox6 - Rectum Cancer | Phase 2 | Recruiting | Menoufia University | 100 | 2025-01-25 | 2025-02-19 |
| Target-specific immunoPET Imaging of Digestive System Carcinoma [68Ga]Ga-DOTA-H2D3, [18F]F-RESCA-RB14, [68Ga]Ga-NOTA-T4 - Malignancy, Digestive Cancer | Not applicable | Recruiting | RenJi Hospital | 400 | 2024-12-04 | 2025-12-31 |
| Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine - Colorectal Cancer, Colon Cancer | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 85 | 2024-09-29 | 2024-11-05 |
| Conformal Sphincter-Preservation Operation Versus InterSphincteric Resection on Anal Function in Low Rectal Cancer CSPO, ISR - Rectum Cancer | Not applicable | Not yet recruiting | Changhai Hospital | 84 | 2024-09-01 | 2024-08-23 |
| A Clinical Evaluation of AI Solutions Developed in the CHAIMELEON Project for Cancer: Prostate, Lung, Breast, Colon and Rectum Risk in prostate cancer, Life expectancy in lung cancer, Histological subtype - Breast Cancer, Lung Cancer, Non-Small Cell | Completed | Instituto de Investigacion Sanitaria La Fe | 300 | 2024-09-01 | 2025-04-30 | |
| Assessment of DW-MRI Measures : Reproducibility and Repeatability in Pelvic Imaging on MR-Linac With Healthy Volunteers Magnetic Resonance Imaging (MRI) - Rectum Cancer, Pelvic Cancer | Not applicable | Unknown | Jules Bordet Institute | 30 | 2024-06-13 | 2024-06-14 |
| Image-Guided Surgery In The Treatment Of Rectal Cancer (AR_CRC) augmented reality - Rectum Cancer | Not applicable | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 50 | 2024-05-29 | 2025-02-03 |
| End to End Versus Side to End Anastomosis After Anterior Resection of Cancer Rectum Anterior resection of Rectal cancer - Rectum Cancer | Not applicable | Unknown | Sohag University | 20 | 2024-03-05 | 2024-03-15 |
| SGM-101 in Colorectal Brain Metastases. SGM-101 - Rectal Neoplasms, Rectum Cancer | Phase 2 | Unknown | Leiden University Medical Center | 10 | 2024-01-01 | 2024-05-09 |
| Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS) Online adaptive radiation therapy - Prostate Cancer, Head and Neck Cancer | Recruiting | Charite University, Berlin, Germany | 649 | 2023-10-11 | 2023-11-03 | |
| Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPE Plastic surgery of the pelvic floor and perineal wound with counter-displaced skin-subcutaneous fascial flaps after extralevatory abdominal-perineal extirpation of the rectum, Plastic surgery of the pelvic floor and perineal wound with local tissues, Plastic surgery of the pelvic floor and perineal wound with mesh endoprosthesis - Rectum Cancer | Not applicable | Unknown | Kuban State Medical University | 150 | 2023-10-01 | 2023-10-10 |
| Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME) Regorafenib, XmAb20717 - Colorectal Cancer, Colon Cancer | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2023-05-17 | 2024-04-29 | |
| Adaptive Symptom Self-Management Immunotherapy Study Automated Telephone Symptom Management (ATMS) and Telephone Interpersonal Counseling (TIP-C), Active control comparator - Breast Cancer, Colon Cancer | Not applicable | Active not recruiting | University of Arizona | 400 | 2023-05-08 | 2026-07-31 |
| Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer. J-pouch anastomosis, direct anastomosis - Rectum Cancer, Faecal Incontinence | Unknown | Shanghai 10th People's Hospital | 154 | 2022-12-01 | 2024-09-19 | |
| Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer Vactosertib, Fludarabine Phosphate, Cyclophosphamide - Colorectal Cancer, Hematologic Malignancy | Phase 1 | Suspended | David Wald | 12 | 2022-09-09 | 2026-07-14 |
| Improving Care for Rural Patients With Solid Tumors CARES Intervention - Lung Cancer, Head and Neck Cancer | Not applicable | Recruiting | University of Colorado, Denver | 320 | 2022-09-01 | 2026-02-05 |
| Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritoneal Malignancy Exercise, Nutrition - Peritoneal Malignancy, Ovarian Cancer | Not applicable | Unknown | Dublin City University | 36 | 2022-09-01 | 2024-03-21 |
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Rectal Neoplasms (63) · Colonic Neoplasms (25) · Colorectal Neoplasms (9) · Prostatic Neoplasms (7) · Breast Neoplasms (6) · Neoplasms (6) · Anastomotic Leak (5) · Esophageal Neoplasms (5) · Head and Neck Neoplasms (5) · Lung Neoplasms (5) · Stomach Neoplasms (5) · Uterine Cervical Neoplasms (5) · Gastrointestinal Neoplasms (4) · Appendiceal Neoplasms (3) · Encopresis (3)
Digestive System Diseases (63) · Neoplasms by Site (63) · Rectal Diseases (63) · Digestive System Neoplasms (62) · Gastrointestinal Diseases (62) · Intestinal Diseases (62) · Intestinal Neoplasms (62) · Gastrointestinal Neoplasms (59) · Neoplasms (57) · Colorectal Neoplasms (54) · Colonic Diseases (31) · Pathological Conditions, Signs and Symptoms (12) · Genital Diseases (10) · Pathologic Processes (10) · Urogenital Diseases (10)
Oxaliplatin (4) · Capecitabine (3) · Cetuximab (2) · Cyclophosphamide (2) · Interleukin-2 (2) · Neoadjuvant Therapy (2) · pembrolizumab (2) · Acetaminophen (1) · Art Therapy (1) · Betacyanins (1) · Bevacizumab (1) · Biopsy (1) · Brachytherapy (1) · Bupivacaine (1) · Chemotherapy, Adjuvant (1)
Johns Hopkins Bloomberg School of Public Health (2) · Maastricht Radiation Oncology (2) · Shanghai 10th People's Hospital (2) · Southwest Hospital, China (2) · University of Colorado, Denver (2) · Yanhong Deng (2) · Alexandria University (1) · Assistance Publique - Hôpitaux de Paris (1) · Cedars-Sinai Medical Center (1) · Changhai Hospital (1) · Charite University, Berlin, Germany (1) · Cihangir Akyol (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Copenhagen University Hospital at Herlev (1) · David Wald (1)
United States (14) · China (13) · France (4) · Netherlands (4) · Denmark (3) · Belgium (2) · Egypt (2) · Finland (2) · Germany (2) · Italy (2) · Spain (2) · Ireland (1) · Monaco (1) · Switzerland (1) · Thailand (1)
Cheng-Le Zhuang, MD, PhD (2) · AbdElhafez H Mohamed, MD (1) · Adrian Dobs, MD (1) · Ahmed A Ahmed, MD (1) · Alex Casalots, Pathologist (1) · Alexander L Vahrmeijer, MD, PhD (1) · Alexis Leal, MD (1) · Ana Darnell, Radiologist (1) · Anita Y Kinney, PhD, RN (1) · Anna Caltrava, Pathologist (1) · Antonieta Salud, Oncologist (1) · Antonio Lazy, Surgeon (1)
PMID 19135997, PMID 19209273, PMID 19535182, PMID 23629519, PMID 25209376, PMID 28895143, PMID 29361435, PMID 30054634, PMID 30770766, PMID 30866859, PMID 31960953, PMID 32416765, PMID 34001462, PMID 34184246, PMID 35119520, PMID 35840912, PMID 36299392, PMID 36927812, PMID 37060023, PMID 37944025, PMID 38814627, PMID 40323625, PMID 40616105, PMID 42469198, PMID 42536277
P30CA046934 (2), R01CA218416 (1), R01CA252211 (1), R01CA254730 (1), R01CA263714 (1)