12 completed, 6 terminated, 1 active not recruiting, 1 withdrawn. 20 Phase 2, 7 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 12, Terminated 6, Active not recruiting 1, Withdrawn 1 |
| Phase 3 | 7 | Completed 6, Active not recruiting 1 |
| Phase 1 | 2 | Terminated 1, Withdrawn 1 |
Follow Pulmonary Aspergillosis: new trials by email Literature Review of Pulmonary Aspergillosis trials Research Report on Pulmonary Aspergillosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| iMagIng pulmonaRy Aspergillosis Using Gallium-68-dEferoxamine Radiopharmaceutical: gallium-68-deferoxamine ([68Ga]Ga-DFO-B) - Pulmonary Aspergillosis, Chronic Pulmonary Aspergillosis | Phase 2 | Completed | Radboud University Medical Center | 10 | 2025-05-01 | 2026-08-18 |
| Study to Evaluate Itraconazole Administered as Inhaled Dry Powder in Adults With Asthma and ABPA Itraconazole Powder, Placebo - ABPA | Phase 2 | Terminated | Pulmatrix Inc. | 8 | 2023-02-01 | 2024-04-02 |
| An Open-label Safety Study of PC945 (Opelconazole) Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients (OPERA-S Study) Opelconazole, Standard of Care - Pulmonary Aspergillosis | Phase 2 | Completed | Pulmocide Ltd | 102 | 2021-11-19 | 2026-04-30 |
| Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED) dupilumab, Placebo - Allergic Bronchopulmonary Aspergillosis | Phase 2 | Completed | Regeneron Pharmaceuticals | 62 | 2020-09-15 | 2025-04-04 |
| Deflazacort Vs. Prednisolone in Acute-stage ABPA Deflazacort, Prednisolone - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Active not recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 150 | 2020-01-15 | 2025-02-28 |
| Open-label Study of APX001 for Treatment of Patients With Invasive Mold Infections Caused by Aspergillus or Rare Molds fosmanogepix - Invasive Fungal Infections | Phase 2 | Terminated | Basilea Pharmaceutica | 21 | 2020-01-04 | 2025-09-16 |
| Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis PUR1900, Placebo - Allergic Bronchopulmonary Aspergillosis | Phase 2 | Terminated | Pulmatrix Inc. | 7 | 2019-07-31 | 2021-08-27 |
| Evaluate Safety and Efficacy of the Coadministration of Ibrexafungerp With Voriconazole in Patients With Invasive Pulmonary Aspergillosis SCY-078, Voriconazole, Oral Placebo Tablets - Invasive Pulmonary Aspergillosis | Phase 2 | Terminated | Scynexis, Inc. | 22 | 2019-01-22 | 2024-08-09 |
| VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults Investigational Agent: VL-2397, Standard treatment: Voriconazole, Isavuconazole, or Liposomal amphotericin B - Invasive Aspergillosis, Invasive Pulmonary Aspergillosis | Phase 2 | Terminated | Vical | 4 | 2018-02-20 | 2019-02-27 |
| Study on Safety and Pharmacokinetics of Intravenous F901318 for Fungal Prophylaxis in AML Patients F901318, Caspofungin - Pulmonary Aspergillosis - Invasive, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Withdrawn | F2G Ltd | 2017-04-20 | 2018-02-15 | |
| A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Glucocorticoids, Vitamin D - Allergic Bronchopulmonary Aspergilloses | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 30 | 2016-12-01 | 2018-08-23 |
| Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in Maintenance Treatment of Allergic Bronchopulmonary Aspergillosis (Cystic Fibrosis Excluded). Liposomal amphotericin B (Ambisome®), placebo - Allergic Bronchopulmonary Aspergillosis | Phase 2 | Completed | Poitiers University Hospital | 174 | 2014-11-19 | 2020-06-09 |
| A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Itraconazole, Glucocorticoids - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 191 | 2014-05-01 | 2022-10-07 |
| Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis Prednisolone, Voriconazole - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2013-06-01 | 2017-12-12 |
| A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Inhaled budesonide, Inhaled amphotericin - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 21 | 2013-05-01 | 2015-08-05 |
| Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients Placebo, QBW251 - Cystic Fibrosis | Phase 1 / Phase 2 | Terminated | Novartis Pharmaceuticals | 153 | 2012-07-31 | 2020-12-30 |
| Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia AMPHOTERICIN B - Invasive Pulmonary Aspergillosis, Lymphoblastic Leukaemia | Phase 2 | Completed | Fundació Sant Joan de Déu | 32 | 2011-10-01 | 2018-03-29 |
| Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Glucocorticoids, Itraconazole - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 100 | 2011-04-01 | 2017-03-16 |
| Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Glucocorticoids - Allergic Bronchopulmonary Aspergillosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 92 | 2009-04-01 | 2015-02-24 |
| Prophylaxis of Fungal Invasive Infections in Leukemia Caspofungin - Invasive Pulmonary Aspergillosis | Phase 2 | Completed | Northern Italy Leukemia Group | 100 | 2007-01-01 | 2009-09-22 |
Aspergillosis, Allergic Bronchopulmonary (13) · Invasive Pulmonary Aspergillosis (5) · Aspergillosis (4) · Asthma (3) · Mycoses (3) · Invasive Fungal Infections (2) · Leukemia (2) · COVID-19 (1) · Cystic Fibrosis (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myelomonocytic, Acute (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Bacterial Infections and Mycoses (20) · Infections (20) · Lung Diseases (20) · Lung Diseases, Fungal (20) · Respiratory Tract Diseases (20) · Mycoses (17) · Aspergillosis (16) · Immune System Diseases (14) · Respiratory Tract Infections (14) · Hypersensitivity (13) · Hypersensitivity, Immediate (13) · Respiratory Hypersensitivity (13) · Invasive Fungal Infections (4) · Bronchial Diseases (3)
Glucocorticoids (4) · Prednisolone (3) · liposomal amphotericin B (3) · Azoles (2) · Caspofungin (2) · Itraconazole (2) · Voriconazole (2) · Amphotericin B (1) · Standard of Care (1) · Steroids (1) · Vitamin D (1) · deflazacort (1) · dupilumab (1) · ibrexafungerp (1) · icenticaftor (1)
Post Graduate Institute of Medical Education and Research, Chandigarh (7) · Pulmatrix Inc. (2) · Basilea Pharmaceutica (1) · F2G Ltd (1) · Fundació Sant Joan de Déu (1) · Northern Italy Leukemia Group (1) · Novartis Pharmaceuticals (1) · Poitiers University Hospital (1) · Pulmocide Ltd (1) · Radboud University Medical Center (1) · Regeneron Pharmaceuticals (1) · Scynexis, Inc. (1) · Vical (1)
India (8) · United States (8) · France (5) · Germany (5) · Belgium (4) · United Kingdom (4) · Canada (3) · Australia (2) · Netherlands (2) · Poland (2) · Romania (2) · Bulgaria (1) · Hungary (1) · Ireland (1) · Israel (1)
Ritesh Agarwal, MD, DM (2) · Chiara Cattaneo (1) · Chris Cabell, MD (1) · David Angulo, MD (1) · David Denning, FRCP, FRC Path, FIDSA, FMedSci (1) · Giuseppe Rossi, MD (1) · Jesus Estella, PhMD (1) · Mammen P Mammen, MD, FIDSA (1) · Marc Engelhardt (1) · Oliver Cornely, PhD, MD (1) · William J. Calhoun, MD (1)
PMID 21729932, PMID 26585431, PMID 29331473, PMID 30049743, PMID 30561849, PMID 33027187, PMID 33293212, PMID 34764182, PMID 38387646, PMID 40203286, PMID 42845221
2019 (2), 2017 (1), 2018 (1), 2023 (1)