12 completed, 3 terminated, 1 withdrawn. 12 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 11, Terminated 1 |
| Phase 2 | 3 | Terminated 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Allergic Bronchopulmonary Aspergillosis Prescreening Study Allergic Bronchopulmonary Aspergillosis, Asthma | Withdrawn | Community Pharmacology Services Ltd | 2024-01-10 | 2024-01-16 | ||
| Study to Evaluate Itraconazole Administered as Inhaled Dry Powder in Adults With Asthma and ABPA Itraconazole Powder, Placebo - ABPA | Phase 2 | Terminated | Pulmatrix Inc. | 8 | 2023-02-01 | 2024-04-02 |
| A Study to Assess the Safety, Tolerability, and Pharmacokinetics of PUR3100 in Health Adults PUR3100, Dihydroergotamine (D.H.E 45), Matching Placebo for PUR3100 - Healthy | Phase 1 | Completed | Pulmatrix Inc. | 26 | 2022-06-09 | 2022-12-23 |
| A Phase 1b Study of PUR1800 in Patients With COPD Placebo Comparator, PUR1800 250 ug, PUR1800 500 ug - Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 | Completed | Pulmatrix Inc. | 18 | 2021-01-04 | 2022-06-27 |
| Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis PUR1900, Placebo - Allergic Bronchopulmonary Aspergillosis | Phase 2 | Terminated | Pulmatrix Inc. | 7 | 2019-07-31 | 2021-08-27 |
| Safety, Tolerability and Pharmacokinetics of PUR1900 (Itraconazole Powder) in Healthy Volunteers and Adults With Asthma Itraconazole Powder, Itraconazole 200 mg - Asthma | Phase 1 | Completed | Pulmatrix Inc. | 58 | 2018-02-09 | 2018-07-27 |
| A PK Study to Evaluate PUR0200 and a Reference Product in Healthy Subjects PUR0200, Reference Product - Healthy | Phase 1 | Completed | Pulmatrix Inc. | 42 | 2016-01-01 | 2016-11-11 |
| A Phase I/II Double-Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of RUT058-60 RUT058-60, Sterile saline for irrigation - Postoperative Wound Infection-deep, Post Operative Wound Infection | Phase 1 / Phase 2 | Terminated | Pulmatrix Inc. | 9 | 2014-10-01 | 2021-01-12 |
| 21 Day Cumulative Skin Irritation of RUT058-60 Hypochlorous acid solution 106 mg/L, 0.1% (w/v) Sodium Lauryl Sulfate, 0.9% Physiological Saline, USP - Irritation/Irritant | Phase 1 | Completed | Pulmatrix Inc. | 43 | 2014-07-01 | 2016-02-04 |
| A Safety, Pharmacokinetic and Pharmacodynamic Study of PUR0200 in COPD Patients PUR0200, PUR0200 Placebo, Active comparator - Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 | Completed | Pulmatrix Inc. | 38 | 2013-07-01 | 2014-03-18 |
| Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers PUR118 - Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 | Completed | Pulmatrix Inc. | 24 | 2012-08-01 | 2013-07-19 |
| A Safety and Tolerability Study OF PUR118 In Subjects With Cystic Fibrosis PUR118 - Cystic Fibrosis | Phase 1 | Completed | Pulmatrix Inc. | 10 | 2012-02-01 | 2013-07-19 |
| Safety, Tolerability, and Pharmacodynamic Effect Study of PUR118 PUR118 - Chronic Obstructive Pulmonary Disease | Phase 1 | Completed | Pulmatrix Inc. | 90 | 2011-02-01 | 2012-09-07 |
| Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum Chronic Obstructive Pulmonary Disease | Completed | Pulmatrix Inc. | 10 | 2010-04-01 | 2011-04-11 | |
| Effect of PUR003 on Asthma PUR003, Placebo - Asthma, Lung Diseases | Phase 1 | Completed | Pulmatrix Inc. | 7 | 2009-12-01 | 2011-11-22 |
| Safety and Efficacy Study of Inhaled PUR003 on a Controlled Influenza Virus Challenge in Healthy Adult Subjects PUR003, Placebo - Healthy | Phase 1 | Completed | Pulmatrix Inc. | 24 | 2009-07-01 | 2017-09-19 |
Pulmonary Disease, Chronic Obstructive (5) · Asthma (4) · Aspergillosis, Allergic Bronchopulmonary (3) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Aspergillosis (1) · Bronchial Diseases (1) · Bronchitis (1) · Cystic Fibrosis (1) · Fibrosis (1) · Inflammation (1) · Influenza, Human (1) · Respiration Disorders (1) · Surgical Wound Infection (1)
PUR003 (2) · Dihydroergotamine (1) · Itraconazole (1) · Sodium Dodecyl Sulfate (1) · Therapeutic Irrigation (1)
United Kingdom (9) · United States (5) · Australia (3) · Bulgaria (1) · Canada (1) · France (1) · Germany (1) · India (1) · Poland (1)
AnaMaria Garza, MD (1) · Chris Cabell, MD (1) · Dave Singh, Prof (1) · David Denning, FRCP, FRC Path, FIDSA, FMedSci (1) · David Hava, Ph.D. (1) · David Hava, PhD (1) · Harold Minkowitz, MD (1) · James Roach, MD (1) · John Hanrahan, MD (1) · John P Hanrahan, MD (1) · John Pullman, M.D. (1) · Margaret Wasilewski, MD (1) · Parameswaran Nair, MD, PhD (1) · Paul Rider, MD (1) · Sanjay Sethi, MD (1)