5 completed, 5 terminated. 6 Phase 2, 3 Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Terminated 4, Completed 2 |
| Phase 1 | 3 | Completed 3 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis (OPERA-T Study) PC945, Placebo - Refractory IPA | Phase 3 | Terminated | Pulmocide Ltd | 85 | 2022-06-14 | 2026-04-30 |
| An Open-label Safety Study of PC945 (Opelconazole) Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients (OPERA-S Study) Opelconazole, Standard of Care - Pulmonary Aspergillosis | Phase 2 | Completed | Pulmocide Ltd | 102 | 2021-11-19 | 2026-04-30 |
| The Effect of Early Treatment of PC945 on Aspergillus Fumigatus Lung Infection in Lung Transplant Patients. PC945, Standard of Care - Aspergillosis, Lung Transplant Infection | Phase 2 | Terminated | Pulmocide Ltd | 2 | 2019-09-17 | 2021-07-16 |
| The Effect of PC945 on Aspergillus Fumigatus Lung Infection in Patients With Cystic Fibrosis PC945 - Aspergillosis, Cystic Fibrosis | Phase 2 | Terminated | Pulmocide Ltd | 4 | 2019-04-03 | 2021-07-16 |
| The Effect of PC945 on Aspergillus or Candida Lung Infections in Patients With Asthma or Chronic Respiratory Diseases PC945, Placebo - Asthma, Respiratory Candidiasis | Phase 2 | Terminated | Pulmocide Ltd | 13 | 2018-11-15 | 2020-06-12 |
| Anti-viral Effect of PC786 on RSV Infection on HSCT Recipients PC786, Placebo, SOC - Respiratory Syncytial Virus Infections | Phase 2 | Terminated | Pulmocide Ltd | 5 | 2018-11-05 | 2019-06-12 |
| A Study of PC786 to Evaluate the Antiviral Activity, Safety and Pharmacokinetics of Multiple Doses in an RSV Challenge Study PC786, Placebo/vehicle - Respiratory Syncytial Virus Infections | Phase 1 / Phase 2 | Completed | Pulmocide Ltd | 56 | 2017-11-14 | 2018-05-16 |
| A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of PC945 PC945 - single doses, Placebo - single doses, PC945 - repeat doses - Aspergillosis | Phase 1 | Completed | Pulmocide Ltd | 29 | 2017-10-23 | 2018-05-01 |
| A Study to Investigate the Safety and Tolerability of Single and Repeat Doses of PC786 PC786 - Single doses, Placebo - Single doses, PC786 - Repeat doses - Respiratory Syncytial Virus (RSV) | Phase 1 | Completed | Pulmocide Ltd | 39 | 2017-06-21 | 2017-12-21 |
| Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis Nasal and Bronchial Sampling - Bronchiolitis, Bronchiolitis, Viral | Not applicable | Completed | Imperial College Healthcare NHS Trust | 152 | 2015-10-02 | 2019-11-12 |
Aspergillosis (3) · Respiratory Syncytial Virus Infections (3) · Asthma (2) · Bronchiectasis (1) · Bronchiolitis (1) · Bronchiolitis, Viral (1) · Cystic Fibrosis (1) · Invasive Pulmonary Aspergillosis (1) · Pulmonary Aspergillosis (1) · Pulmonary Disease, Chronic Obstructive (1) · Respiratory Insufficiency (1)
PC-786 (3) · Standard of Care (2)
United Kingdom (9) · Canada (2) · United States (2) · Argentina (1) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · Colombia (1) · France (1) · Germany (1) · Greece (1) · India (1) · Israel (1)
Alison Murray (1) · Bryan J Murray, MBBS (1) · Malcolm J Boyce, MBChB, MD (1) · Muna Albayaty, MBChB, FFPM, MSc (1)
2018 (4), 2015 (1), 2016 (1), 2017 (1)