11 recruiting, 4 unknown, 3 completed, 1 active not recruiting. 9 Not applicable, 5 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Recruiting 4, Completed 3, Active not recruiting 1, Unknown 1 |
| Phase 2 | 5 | Unknown 3, Recruiting 2 |
| Phase 1 | 3 | Unknown 2, Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Proton Therapy: new trials by email Literature Review of Proton Therapy trials Research Report on Proton Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UPRIGHT-PRO: Prospective Development Study of Upright Proton Therapy Standard-of-Care Proton Therapy - Proton Therapy | Not yet recruiting | Stanford University | 450 | 2026-09-01 | 2026-07-16 | |
| Clinical Evaluation of a Treatment Planning Software and Oncology Information System for Proton Therapy Treatment Planning Software - Proton Therapy | Not applicable | Recruiting | University of Wisconsin, Madison | 180 | 2026-07-15 | 2026-08-12 |
| Protoacoustic Imaging For 3D Mapping Radiacoustic Imaging w/Ultrasound. - Proton Therapy, Radiation Therapy, Secondary Skin Reactions | Recruiting | University of Oklahoma | 24 | 2026-06-10 | 2026-09-22 | |
| HUmanitas PROtontherapy (HU-PRO) Cancer, Proton Therapy | Recruiting | Istituto Clinico Humanitas | 500 | 2026-01-12 | 2026-01-21 | |
| Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS Proton Total Marrow Irradiation - Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)/AML | Phase 1 / Phase 2 | Recruiting | Institute of Hematology and Blood Transfusion, Czech Republic | 16 | 2025-11-21 | 2026-04-16 |
| Safety and Efficacy of IMPT or IMRT for Breast Cancer Postoperative radiotherapy, Preoperative Radiotherapy, Definitive Radiotherapy - Breast Cancer, Proton Therapy | Recruiting | Ruijin Hospital | 500 | 2024-12-01 | 2025-02-14 | |
| Ultra-Hypofractionated vs. Moderately Hypofractionated Proton Therapy for Early Breast Cancer After Lumpectomy moderate hypofractionated proton radiotherapy, ultra-hypofractionated proton radiotherapy - Breast Cancer, Proton Therapy | Not applicable | Recruiting | Shanghai Proton and Heavy Ion Center | 312 | 2024-10-10 | 2025-08-22 |
| Proton Therapy for Locally Advanced Cervical Cancer Proton therapy - Cervical Cancer, Proton Therapy | Phase 2 | Recruiting | University of Aarhus | 55 | 2024-05-20 | 2024-06-17 |
| Interest of a Weekly Consultation by a Medical Electro Radiology Manipulator (MERM) in Addition to the Follow-up by the Radiotherapist to Improve the Collection of Radio-induced Toxicities in Patients Undergoing Proton Therapy Consultation with Manipulator in Medical Radiology and a radiotherapist, Consultation with a radiotherapist - Paramedical Consultation, Radiotherapy | Not applicable | Active not recruiting | Centre Francois Baclesse | 92 | 2023-05-17 | 2025-09-17 |
| Study on the Safety and Effectiveness of Varian ProBeam Proton Therapy Equipment in the Treatment of Solid Tumors Proton radiation therapy - Solid Tumor, Radiation Therapy | Not applicable | Completed | Guangzhou Concord Cancer Center | 47 | 2022-12-15 | 2023-11-07 |
| HYpofractionated, Dose-redistributed RAdiotherapy With Protons and Photons in HNSCC HYpofractionated, Dose-redistributed RAdiotherapy (HYDRA), conventional fractionated radiotherapy - Head and Neck Squamous Cell Carcinoma, Hypofractionation | Not applicable | Unknown | Joris B.W. Elbers | 100 | 2022-10-10 | 2024-02-20 |
| PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy Photon Radiotherapy, Proton Radiotherapy - Esophageal Cancer, Radiotherapy | Phase 3 | Recruiting | University of Aarhus | 396 | 2022-05-01 | 2024-12-17 |
| Virtual Reality for Children in Radiotherapy (REVER) Virtual reality - Virtual Reality, Proton Therapy | Not applicable | Recruiting | Centre Antoine Lacassagne | 47 | 2021-08-02 | 2026-05-29 |
| Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received MRI 3 tesla - Benign Brain Tumors, Proton Therapy | Not applicable | Completed | Centre Francois Baclesse | 20 | 2021-04-22 | 2023-03-08 |
| Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas Bone Neoplasm of Vertebral Column, Chordoma | Recruiting | Leiden University Medical Center | 40 | 2021-02-02 | 2023-11-18 | |
| Preoperative, Proton- Radiotherapy Combined With Chemotherapy for Borderline Resectable Pancreatic Cancer Proton Ions, Nab-PACLitaxel, Gemcitabine - Pancreatic Cancer, Proton Therapy | Not applicable | Recruiting | EBG MedAustron GmbH | 10 | 2020-09-14 | 2026-03-20 |
| Combination of Proton Therapy With Immunotherapy in Multiple Metastases Cancer Radiation: Proton Therapy+PD-1 Ab - Proton Therapy, Immunotherapy | Phase 1 / Phase 2 | Unknown | Peking University First Hospital | 30 | 2019-01-01 | 2018-12-05 |
| Combination of Hypofractionated Proton Therapy With Immunotherapy Radiation+PD-1 Ab - Proton Therapy, Immunotherapy | Phase 1 / Phase 2 | Unknown | Peking University First Hospital | 30 | 2019-01-01 | 2018-12-05 |
| Feasibility of High Dose PROton Therapy On Unresectable Primary Carcinoma Of Liver: Prospective Phase II Trial Proton arm - Liver Neoplasm, Proton Therapy | Phase 2 | Unknown | Samsung Medical Center | 66 | 2015-12-01 | 2018-04-12 |
| Proton Beam Therapy in Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Proton beam therapy - Liver Neoplasm, Portal Vein Tumor Thrombosis | Not applicable | Completed | Samsung Medical Center | 53 | 2015-08-01 | 2023-11-22 |
Liver Neoplasms (3) · Brain Neoplasms (2) · Breast Neoplasms (2) · Neoplasms (2) · Anemia, Refractory, with Excess of Blasts (1) · Chondrosarcoma (1) · Chordoma (1) · Esophageal Neoplasms (1) · Leukemia, Myeloid, Acute (1) · Myelodysplastic Syndromes (1) · Neoplasm Metastasis (1) · Pancreatic Neoplasms (1) · Prostatic Neoplasms (1) · Radiation Injuries (1) · Squamous Cell Carcinoma of Head and Neck (1)
Neoplasms (14) · Neoplasms by Site (11) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Liver Diseases (3) · Neoplasms by Histologic Type (3) · Brain Diseases (2) · Breast Diseases (2) · Central Nervous System Diseases (2) · Central Nervous System Neoplasms (2) · Genital Diseases (2) · Head and Neck Neoplasms (2) · Nervous System Diseases (2) · Nervous System Neoplasms (2) · Skin Diseases (2)
Proton Therapy (4) · 130-nm albumin-bound paclitaxel (1) · Albumin-Bound Paclitaxel (1) · Capecitabine (1) · Gemcitabine (1) · Protons (1) · Referral and Consultation (1)
Centre Francois Baclesse (2) · Peking University First Hospital (2) · Samsung Medical Center (2) · University of Aarhus (2) · Centre Antoine Lacassagne (1) · EBG MedAustron GmbH (1) · Guangzhou Concord Cancer Center (1) · Institute of Hematology and Blood Transfusion, Czech Republic (1) · Istituto Clinico Humanitas (1) · Joris B.W. Elbers (1) · Leiden University Medical Center (1) · Ruijin Hospital (1) · Shanghai Proton and Heavy Ion Center (1) · Stanford University (1) · University of Oklahoma (1)
France (4) · China (3) · Netherlands (3) · United States (3) · Denmark (2) · Italy (2) · South Korea (2) · Austria (1) · Belgium (1) · Czechia (1) · Germany (1) · Switzerland (1) · United Kingdom (1)
Xianshu Gao, MD,PhD (2) · Benjamin Durkee, MD, PhD (1) · Gang Cai, MD (1) · Hanne Matthiesen, MD, PhD (1) · Hans Bloem, prof. MD PhD (1) · Jia-Yi Chen, PhD, MD (1) · Joon Hyeok Lee, MD, PhD (1) · Joris BW Elbers, MD, PhD (1) · Karin Haustermans, Dr. (1) · Marianne Nordsmark, Dr. (1) · Piero Fossati, M.D. (1) · Shen Fu, Professor (1) · Stijn Krol, MD PhD (1) · Yimin Liu, Professor (1)