30 completed, 10 unknown, 6 recruiting, 4 not yet recruiting. 50 Not applicable, 3 Phase 4, 1 Phase 1, 1 Phase 2, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VR for Steroid Joint Injections - Feasibility VR-PAT - Acute Pain, Procedural Anxiety | Not applicable | Enrolling by invitation | Nationwide Children's Hospital | 10 | 2026-10-08 | 2026-10-20 |
| Virtual Reality (VR) Audiovisual Distraction to Reduce Pain and Anxiety for Prone Pain Procedures Virtual Reality (VR) Audiovisual Distraction - Procedural Pain, Procedural Anxiety | Not applicable | Not yet recruiting | University of California, Davis | 230 | 2026-10-01 | 2026-08-21 |
| Evaluating Operation Calm With Children, Parents, and Clinicians Operation Calm EEMCF-VR - Preoperative Anxiety Experienced by the Pediatric Patient, Dental Anxiety in Children | Not applicable | Recruiting | McGill University | 150 | 2026-10-01 | 2026-10-28 |
| Effect of White Noise on Salivary Cortisol and Vital Signs During Gastroscopy White Noise - Procedural Anxiety, Physiological Stress | Not applicable | Not yet recruiting | Yuzuncu Yil University | 100 | 2026-09-27 | 2026-09-02 |
| Virtual Reality-Assisted Cast Application in Children With Forearm Fractures Virtual Reality-Based Educational Animation, Standard Care - Forearm Fractures, Procedural Anxiety | Not applicable | Completed | Başakşehir Çam & Sakura City Hospital | 158 | 2026-07-01 | 2026-10-13 |
| Effect of Music on Pain and Anxiety During Nail Biopsies Music intervention, Local anesthesia injections - Procedural Anxiety, Pain | Not applicable | Recruiting | Weill Medical College of Cornell University | 30 | 2026-06-18 | 2026-08-04 |
| Stress Ball and Empathic Verbal-Tactile Interventions for Reducing Anxiety and Pain in Mammography and Breast Ultrasonography: A Randomized Trial Stress Ball, Empathic Verbal-Tactile Intervention - Procedural Anxiety, Procedural Pain | Not applicable | Not yet recruiting | Istanbul University | 122 | 2026-05-04 | 2026-05-01 |
| Technology-Based Distractions for Minor Procedures Standard of Care, Immersive technology - Anxiety, Procedural Anxiety | Not applicable | Withdrawn | Stanford University | 2026-05-01 | 2026-08-18 | |
| The Effect of Two Different Types of Hourglasses on Pain, Fear, and Anxiety Liquid Gel-Based Hourglass, Sand-Based Hourglass - Pain, Fear | Not applicable | Completed | Hakkari Universitesi | 120 | 2026-05-01 | 2026-09-15 |
| Artificial Intelligence-Supported Visual Guide for Preschool Children Undergoing Medical Procedures AI-Supported Visual Guide - Procedural Anxiety, Procedural Pain | Not applicable | Completed | Istanbul Bilgi University | 110 | 2026-04-14 | 2026-07-15 |
| Video-based Intervention to Reduce Anxiety in Patients Undergoing Elective PCI Video intervention - Procedural Anxiety, Coronary Artery Disease | Not applicable | Recruiting | Tan Tock Seng Hospital | 144 | 2026-03-16 | 2026-03-24 |
| Virtual Reality (VR) for Interventional Radiology (IR) Procedures Meta Oculus Quest Pro, Pico 4, Pico G3 - Pain, Procedural Anxiety | Recruiting | Children's Hospital Los Angeles | 500 | 2026-03-01 | 2026-03-09 | |
| Oral Surgery Virtual Reality Glasses Study Virtual reality (VR) glasses with relaxation module - Procedural Anxiety, Procedural Pain | Not applicable | Recruiting | Boston University | 80 | 2025-11-18 | 2026-07-27 |
| Little NIRVANA for Pediatric Pain and Anxiety Little NIRVANA - Acute Pain, Procedural Anxiety | Not applicable | Enrolling by invitation | Nationwide Children's Hospital | 130 | 2025-11-15 | 2026-08-11 |
| Effects of Rain Stick and Musical Egg on Pain, Fear and Anxiety Rain Stick, Musical Egg - Procedural Pain, Procedural Anxiety | Not applicable | Completed | Hakkari Universitesi | 120 | 2025-10-22 | 2026-07-08 |
| Effects of Liquid Hourglass and Spiky Ball on Pain, Fear, Anxiety and Emotional Manifestations Liquid Hourglass, Spiky Ball - Pain, Anxiety and Fear | Not applicable | Completed | Hakkari Universitesi | 120 | 2025-10-01 | 2026-02-11 |
| Virtual Reality as a Nursing Intervention for Anxiety and Pain in Pediatric Endoscopy Virtual Reality Head-Mounted Display - Gastrointestinal Endoscopy, Procedural Anxiety | Not applicable | Completed | Mansoura University | 66 | 2025-06-03 | 2025-12-10 |
| The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization VR-based intervention (VRReliever Software V0.3.4 fromXRHealth), VR headset without any scenery - Oocyte Retrieval, Adverse Events | Not applicable | Not yet recruiting | Mount Sinai Hospital, Canada | 50 | 2025-01-15 | 2024-12-18 |
| Buzzy® and Cognitive Behavioral Intervention Package During Blood Draw in Children Cognitive Behavioral Intervention Package, Buzzy® - Procedural Pain, Procedural Fear | Not applicable | Completed | Kocaeli University | 180 | 2025-01-10 | 2026-09-15 |
| Effect of Buzzy®, Cognitive Behavioral Intervention, and Kaleidoscope During SC Injection in Children With Cancer Cognitive Behavioral Intervention Package Group, Buzzy® Group, Kaleidoscope Group - Pediatric Cancer, Procedural Pain | Not applicable | Completed | Kocaeli University | 45 | 2024-12-01 | 2026-06-25 |
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Pain, Procedural (33) · Pain (17) · Anxiety Disorders (14) · Acute Pain (2) · Agnosia (2) · Neoplasms (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Autism Spectrum Disorder (1) · Colonic Polyps (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 2 (1) · Emergence Delirium (1) · Emergencies (1) · Generalized Anxiety Disorder (1) · Iatrophobia (1)
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Midazolam (4) · Dexmedetomidine (2) · Music Therapy (2) · Standard of Care (2) · Breathing Exercises (1) · Colonoscopy (1) · Control Groups (1) · Eyeglasses (1) · Ketamine (1) · Nitrous Oxide (1) · Water (1) · almond oil (1) · lavender oil (1) · remimazolam (1)
Hakkari Universitesi (3) · Nationwide Children's Hospital (3) · Akdeniz University (2) · Bandırma Onyedi Eylül University (2) · Brooke Army Medical Center (2) · Children's Hospital Los Angeles (2) · Istanbul University (2) · Kocaeli University (2) · Stanford University (2) · ASST Fatebenefratelli Sacco (1) · Amsterdam UMC, location VUmc (1) · Aynur Aytekin Ozdemir (1) · Başakşehir Çam & Sakura City Hospital (1) · Beth Israel Deaconess Medical Center (1) · Boston Children's Hospital (1)
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Allison Dempsey, PhD (1) · Asim Shuja, MD (1) · Aynur Aytekin Ozdemir, PhD (1) · Christopher Maani, MD (1) · Claire Jones, MD (1) · Cristinel Stefanescu, Prof. MD (1) · Daniel M Fein, MD (1) · Daniel S. Tsze, MD, MPH (1) · Ebru Temizsoy, PhD,RN (1) · Enrico Muzzi, MD (1)
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