10 completed, 4 active not recruiting, 4 recruiting, 2 unknown. 2 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Active not recruiting 1, Completed 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Primary Lateral Sclerosis: new trials by email Literature Review of Primary Lateral Sclerosis trials Research Report on Primary Lateral Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Active not recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-11-06 |
| Digital Assessment of Speech and Fine Motor Control in ALS Digital Speech and Handwriting Assessment - Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Completed | Milton S. Hershey Medical Center | 42 | 2024-07-01 | 2026-06-29 | |
| Spastic Paraplegia - Centers of Excellence Research Network Hereditary Spastic Paraplegia, Primary Lateral Sclerosis | Recruiting | Boston Children's Hospital | 100 | 2024-06-04 | 2026-03-18 | |
| Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Withdrawn | University of Alberta | 2024-01-01 | 2024-02-08 | ||
| Transcutaneous Electrical Stimulation for Spasticity in Patients With Primary Lateral Sclerosis Transcutaneous electrical stimulation - Primary Lateral Sclerosis | Not applicable | Completed | Nova Southeastern University | 6 | 2023-08-28 | 2026-08-25 |
| Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG) - Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy | Unknown | University of Dublin, Trinity College | 240 | 2023-06-15 | 2024-03-20 | |
| Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Recruiting | University of Alberta | 150 | 2021-09-12 | 2026-04-13 | |
| Phenotype, Genotype and Biomarkers 2 Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia | Active not recruiting | University of Miami | 217 | 2021-01-08 | 2026-06-15 | |
| TRIAL READY (Clinical Trial Readiness) Amyotrophic Lateral Sclerosis, Frontotemporal Dementia | Active not recruiting | University of Miami | 610 | 2019-01-22 | 2026-06-15 | |
| Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Completed | Assistance Publique - Hôpitaux de Paris | 71 | 2018-07-05 | 2020-01-29 | |
| Clinical Procedures to Support Research in ALS Amyotrophic Lateral Sclerosis, ALS-Frontotemporal Dementia | Recruiting | University of Miami | 1200 | 2018-02-15 | 2026-06-15 | |
| A Patient Centric Motor Neuron Disease Activities of Daily Living Scale Web-based Survey - Amyotrophic Lateral Sclerosis, Progressive Muscular Atrophy | Completed | University of South Florida | 410 | 2016-12-01 | 2019-10-16 | |
| Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease Stem Cells - Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Unknown | Stem Cells Arabia | 40 | 2016-09-01 | 2018-06-06 |
| Answer ALS: Individualized Initiative for ALS Discovery Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Completed | Johns Hopkins University | 1049 | 2015-12-01 | 2020-01-13 | |
| Imaging Biomarkers in ALS Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis | Recruiting | University of Minnesota | 30 | 2015-09-01 | 2026-11-12 | |
| Phenotype, Genotype & Biomarkers in ALS and Related Disorders Amyotrophic Lateral Sclerosis, Frontotemporal Dementia | Active not recruiting | University of Miami | 708 | 2015-04-01 | 2026-06-15 | |
| Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study Motor Neuron Disease, Primary Lateral Sclerosis | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 10 | 2010-05-13 | 2019-11-05 | |
| Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) No intervention - Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease | Completed | Massachusetts General Hospital | 475 | 2008-04-01 | 2016-06-03 | |
| Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease Levetiracetam - Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Duke University | 20 | 2006-05-01 | 2013-06-19 |
| Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis Primary Lateral Sclerosis, Hereditary Spastic Paraplegia | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 55 | 2001-08-01 | 2008-03-04 |
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Motor Neuron Disease (21) · Amyotrophic Lateral Sclerosis (18) · Muscular Atrophy, Spinal (12) · Spastic Paraplegia, Hereditary (7) · Frontotemporal Dementia (4) · Muscle Spasticity (3) · Neuromuscular Diseases (3) · Disease Progression (2) · Postpoliomyelitis Syndrome (2) · Amyotrophy, monomelic (1) · Bulbar Palsy, Progressive (1) · Bulbo-Spinal Atrophy, X-Linked (1) · Charcot-Marie-Tooth Disease (1) · Dysarthria (1) · Dyskinesias (1)
Neurodegenerative Diseases (21) · Nervous System Diseases (20) · Central Nervous System Diseases (18) · Metabolic Diseases (18) · Neuromuscular Diseases (18) · Nutritional and Metabolic Diseases (18) · Proteostasis Deficiencies (18) · Spinal Cord Diseases (18) · TDP-43 Proteinopathies (18) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (8) · Heredodegenerative Disorders, Nervous System (8) · Pathological Conditions, Signs and Symptoms (8) · Peripheral Nervous System Diseases (8) · Congenital Abnormalities (7)
BID protein, human (1) · Levetiracetam (1) · Transcutaneous Electric Nerve Stimulation (1)
University of Miami (4) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · University of Alberta (2) · Assistance Publique - Hôpitaux de Paris (1) · Boston Children's Hospital (1) · Duke University (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Milton S. Hershey Medical Center (1) · Nova Southeastern University (1) · Stem Cells Arabia (1) · University of Dublin, Trinity College (1) · University of Minnesota (1) · University of Missouri-Columbia (1) · University of South Florida (1)
United States (15) · Canada (3) · South Africa (2) · France (1) · Germany (1) · Ireland (1)
Mary Kay Floeter, M.D. (2) · Michael Benatar, MD, PhD (2) · Alan Boruch, DO, PhD (1) · Callyn Kirk, MSPH (1) · David Walk, MD (1) · Eduardo Locatelli, MD, MPH (1) · Jake Hayward, MD (1) · James D Berry, MD (1) · James D. Berry, MD, MPH (1) · Jeffery Krischer, PhD (1) · Jeffrey Statland, MD (1) · Michael Benatar (1) · Michael Benatar, DPhil (1) · Michael Benatar, MBChB, MS, DPhil (1)
PMID 10540002, PMID 17030772, PMID 17364435, PMID 17709710, PMID 17980667, PMID 19922132, PMID 21706151, PMID 22507681, PMID 23421600, PMID 23944684, PMID 23952636, PMID 24067398, PMID 24070404, PMID 24778202, PMID 25054277, PMID 26205535, PMID 30299161, PMID 33639779, PMID 39185513, PMID 39270623, PMID 4056836, PMID 41343582, PMID 42071279, PMID 8229050, PMID 8302340, PMID 8423829, PMID 8639063, PMID 8858057
U54NS092091 (3), 5RC1NS068179-02 (1), U01NS107027 (1), U01TR001263 (1)