2 completed, 2 recruiting, 1 enrolling by invitation, 1 not yet recruiting. 3 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 1, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Terminated 1 |
| Phase 4 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia Active tES, Cognitive Interventions - PPA | Not applicable | Not yet recruiting | Johns Hopkins University | 10 | 2026-11-01 | 2026-10-27 |
| Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration Theta burst stimulation, Sham Theta burst stimulation - FTLD, FTD | Not applicable | Recruiting | Università degli Studi di Brescia | 120 | 2025-02-13 | 2026-01-05 |
| Nabilone for Agitation in Frontotemporal Dementia Nabilone, Placebo - Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant | Phase 2 | Terminated | Simon Ducharme, MD | 3 | 2023-03-07 | 2026-07-28 |
| Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders C-11 PiB, AV1451 Tau, C-11 ER176 - PSP, CBD | Enrolling by invitation | Mayo Clinic | 500 | 2020-11-01 | 2025-11-21 | |
| Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy Active tDCS plus Speech-Language Therapy, Sham tDCS plus Speech-Language Therapy - Primary Progressive Aphasia, PPA | Not applicable | Completed | Johns Hopkins University | 8 | 2018-10-10 | 2023-04-27 |
| Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech AV-1451 - PPA, Non-fluent Aphasia | Phase 4 | Recruiting | Mayo Clinic | 50 | 2018-07-01 | 2025-11-12 |
| PiB PET Scanning in Speech and Language Based Dementias C-11 PiB, F-18 FDG - PPA, Primary Progressive Aphasia | Phase 1 | Completed | Mayo Clinic | 168 | 2010-03-01 | 2015-12-22 |
Aphasia (4) · Aphasia, Primary Progressive (4) · Frontotemporal Dementia (4) · Apraxias (3) · Aphasia, Broca (2) · Dementia (2) · Pick Disease of the Brain (2) · Primary Progressive Nonfluent Aphasia (2) · Anomia (1) · Frontotemporal Lobar Degeneration (1) · Language (1) · Neurocognitive Disorders (1) · Parkinson Disease (1) · Psychomotor Agitation (1) · Shy-Drager Syndrome (1)
Brain Diseases (6) · Central Nervous System Diseases (6) · Mental Disorders (6) · Metabolic Diseases (6) · Nervous System Diseases (6) · Neurodegenerative Diseases (6) · Nutritional and Metabolic Diseases (6) · Proteostasis Deficiencies (6) · TDP-43 Proteinopathies (6) · Communication Disorders (5) · Frontotemporal Lobar Degeneration (5) · Language Disorders (5) · Neurobehavioral Manifestations (5) · Neurocognitive Disorders (5) · Neurologic Manifestations (5)
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Speech Therapy (1) · nabilone (1)
Mayo Clinic (3) · Johns Hopkins University (2) · Simon Ducharme, MD (1) · Università degli Studi di Brescia (1)
United States (5) · Canada (1) · Italy (1)
Jennifer Whitwell, PhD (1) · Keith A Josephs, M.D. MST, MSc (1) · Kyrana Tsapkini, PhD (1) · Shannon M Sheppard, PhD (1)
R01DC012519 (1)