16 completed. 16 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 16 |
| Phase 2 | 8 | Completed 8 |
Follow Polymyositis: new trials by email Literature Review of Polymyositis trials Research Report on Polymyositis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis Brepocitinib, Placebo - Dermatomyositis | Phase 3 | Completed | Priovant Therapeutics, Inc. | 241 | 2022-10-31 | 2026-09-15 |
| A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy. EFG PH20 SC, PBO - Active Idiopathic Inflammatory Myopathy, Myositis | Phase 2 / Phase 3 | Completed | argenx | 265 | 2022-10-12 | 2026-09-21 |
| Trial to Evaluate Efficacy and Safety of Lenabasum in Dermatomyositis Lenabasum 20 mg, Lenabasum 5 mg, Placebo - Dermatomyositis | Phase 3 | Completed | Corbus Pharmaceuticals Inc. | 176 | 2018-12-17 | 2022-08-16 |
| Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis Sodium Thiosulfate - Dermatomyositis, Idiopathic Inflammatory Myopathies | Phase 2 / Phase 3 | Completed | National Institute of Environmental Health Sciences (NIEHS) | 15 | 2017-10-05 | 2024-11-26 |
| Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy Abatacept subcutaneous, Placebo - Polymyositis, Dermatomyositis | Phase 3 | Completed | Bristol-Myers Squibb | 149 | 2017-05-04 | 2023-10-30 |
| Study Evaluating Efficacy and Safety of Octagam 10% in Patients With Dermatomyositis (Idiopathic Inflammatory Myopathy) Octagam 10%, Placebo - Dermatomyositis | Phase 3 | Completed | Octapharma | 95 | 2017-02-27 | 2021-12-23 |
| Belimumab in Idiopathic Inflammatory Myositis Belimumab, Placebo - Myositis | Phase 2 / Phase 3 | Completed | Northwell Health | 17 | 2015-01-01 | 2024-02-09 |
| Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD Rituximab, Cyclophosphamide - Interstitial Lung Disease, Scleroderma | Phase 2 / Phase 3 | Completed | Royal Brompton & Harefield NHS Foundation Trust | 104 | 2014-11-01 | 2021-10-07 |
| Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM Prednisone, Methotrexate - Polymyositis, Dermatomyositis | Phase 3 | Completed | Institute of Rheumatology, Prague | 31 | 2008-05-01 | 2016-05-12 |
| Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimus Tacrolimus - Interstitial Pneumonitis, Polymyositis | Phase 2 / Phase 3 | Completed | Tokyo Medical and Dental University | 25 | 2007-07-01 | 2020-03-24 |
| Efficacy and Safety Study of GB-0998 for Treatment of Steroid-resistant Polymyositis and Dermatomyositis (PM/DM) GB-0998, Placebo of GB-0998 - Polymyositis, Dermatomyositis | Phase 3 | Completed | Japan Blood Products Organization | 26 | 2006-06-01 | 2014-11-05 |
| Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis 3 MPDN pulse + PDN, 3 MPDN pulse + PDN + CSA, 3 MPDN pulse + PDN + MTX - Juvenile Dermatomyositis | Phase 3 | Completed | Istituto Giannina Gaslini | 139 | 2006-05-31 | 2023-03-28 |
| Anakinra in Myositis Anakinra - Polymyositis, Dermatomyositis | Phase 2 / Phase 3 | Completed | Karolinska Institutet | 2003-09-01 | 2010-07-19 | |
| Alendronate Osteoporosis Study Alendronate - Glucocorticoid-Associated Osteopenia and Osteoporosis | Phase 2 / Phase 3 | Completed | Boston Children's Hospital | 20 | 2003-03-01 | 2017-04-11 |
| Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. Alendronate versus alfacalcidol (1-alpha OH vitamin D) - Rheumatoid Arthritis, Polymyalgia Rheumatica | Phase 3 | Completed | UMC Utrecht | 200 | 2000-05-01 | 2006-11-29 |
| Treatment With TNF Blockade, Infliximab, in Patients With Myositis Infliximab - Refractory Myositis | Phase 2 / Phase 3 | Completed | Karolinska Institutet | 2007-03-05 |
Dermatomyositis (15) · Myositis (5) · Lung Diseases, Interstitial (2) · Mixed Connective Tissue Disease (2) · Myositis, Inclusion Body (2) · Antisynthetase syndrome (1) · Arthritis, Juvenile (1) · Arthritis, Rheumatoid (1) · Calcinosis (1) · Connective Tissue Diseases (1) · Crohn Disease (1) · Giant Cell Arteritis (1) · Granulomatosis with Polyangiitis (1) · Lupus Erythematosus, Systemic (1)
Muscular Diseases (16) · Musculoskeletal Diseases (16) · Nervous System Diseases (16) · Neuromuscular Diseases (16) · Skin Diseases (16) · Skin and Connective Tissue Diseases (16) · Connective Tissue Diseases (15) · Myositis (11) · Lung Diseases (3) · Respiratory Tract Diseases (3) · Arthritis (2) · Autoimmune Diseases (2) · Cardiovascular Diseases (2) · Immune System Diseases (2)
Alendronate (1) · Cyclophosphamide (1) · Immunoglobulins, Intravenous (1) · Infliximab (1) · Interleukin 1 Receptor Antagonist Protein (1) · Methotrexate (1) · Prednisolone (1) · Prednisone (1) · Rituximab (1) · Tacrolimus (1) · anabasum (1) · belimumab (1) · lenabasum (1) · sodium thiosulfate (1)
Karolinska Institutet (2) · Boston Children's Hospital (1) · Bristol-Myers Squibb (1) · Corbus Pharmaceuticals Inc. (1) · Institute of Rheumatology, Prague (1) · Istituto Giannina Gaslini (1) · Japan Blood Products Organization (1) · National Institute of Environmental Health Sciences (NIEHS) (1) · Northwell Health (1) · Octapharma (1) · Priovant Therapeutics, Inc. (1) · Royal Brompton & Harefield NHS Foundation Trust (1) · Tokyo Medical and Dental University (1) · UMC Utrecht (1) · argenx (1)
United States (7) · Czechia (6) · Germany (5) · Italy (5) · Japan (5) · Canada (4) · Hungary (4) · Netherlands (4) · Poland (4) · South Korea (4) · Sweden (4) · United Kingdom (4) · Bulgaria (3) · Mexico (3) · Spain (3)
Adam I Schiffenbauer, M.D. (1) · Alberto Martini, MD, Prof. (1) · Catherine Gordon, MD (1) · Chester V Oddis, MD (1) · Galina Marder, MD (1) · Ingrid E Lundberg, MD, PhD (1) · Jiri Vencovsky, prof. MD. (1) · Nicolino Ruperto, MD, MPH (1) · Nobuyuki Miyasaka, MD, PhD (1) · Nobuyuki Miyasaka, Professor (1) · Toby M Maher, MD PhD (1) · Victoria P Werth, MD (1)
PMID 16914703, PMID 17407214, PMID 17557758, PMID 26645190, PMID 27353816, PMID 27353819, PMID 28619061, PMID 31539061, PMID 33429735, PMID 36198179, PMID 36375479, PMID 37326854, PMID 37799613, PMID 38233885, PMID 39918968, PMID 40383862, PMID 40616720, PMID 41910335, PMID 42646746
2016 (1)