573 completed, 263 unknown, 178 terminated, 95 withdrawn. 1192 Phase 3, 306 Phase 2.
Follow Pneumonia: new trials by email Literature Review of Pneumonia trials Research Report on Pneumonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Echinocandin Added to Standard Treatment for Severe Pneumocystis Pneumonia Echinocandins, Placebo (0.9% Sodium chloride) infusion - Pneumocystis Jirovecii Pneumonia | Phase 3 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 416 | 2027-04-01 | 2026-10-28 |
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Inhaled Lexofloxacin vs Usual Care for Treatment of Community-Acquired Pneumonia Inhaled levofloxacin, Standard-of-care / Usual care - Community-acquired Pneumonia, CAP | Phase 2 / Phase 3 | Not yet recruiting | Copenhagen Respiratory Research | 460 | 2026-09-28 | 2026-09-30 |
| A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe Disease Secutrelvir, Placebo - SARS-CoV-2 | Phase 3 | Recruiting | Shionogi | 2000 | 2026-09-14 | 2026-10-26 |
| Dapagliflozin for Long COVID Syndrome Dapagliflozin (DAPA), Placebo - COVID - 19, Long COVID Syndrome | Phase 3 | Not yet recruiting | Ottawa Heart Institute Research Corporation | 192 | 2026-09-01 | 2026-07-01 |
| CLARITHROMYCIN TO PREVENT SECONDARY INFECTIONS IN PATIENTS WITH SEPSIS FOLLOWING LOWER RESPIRATORY TRACT INFECTIONS: THE CLASSIFY TRIAL Placebo, clarithromycin - Sepsis | Phase 3 | Recruiting | Hellenic Institute for the Study of Sepsis | 252 | 2026-09-01 | 2026-10-28 |
| A Study of COVID-19 Vaccine(s) in Children and Adults BNT162b2 - COVID-19 Vaccines | Phase 3 | Recruiting | BioNTech SE | 700 | 2026-08-31 | 2026-09-28 |
| Study of Secutrelvir in Participants With COVID-19 Secutrelvir, Placebo - COVID-19 | Phase 3 | Recruiting | Shionogi | 1200 | 2026-08-05 | 2026-09-02 |
| A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID Maraviroc (MVC), Atorvastatin, 10mg, 20mg, 40mg, Placebo, Maraviroc - Long COVID | Phase 2 / Phase 3 | Not yet recruiting | HealthBio, Inc. | 252 | 2026-07-15 | 2026-06-18 |
| Safety and Serum Virus Neutralizing Antibody Responses of VYD2311, a COVID-19 Vaccine, and Coadministered VYD2311 With a COVID-19 Vaccine COVID-19 mRNA vaccine, VYD2311, Placebo (Normal Saline) - COVID-19 | Phase 3 | Completed | Invivyd, Inc. | 210 | 2026-06-08 | 2026-10-14 |
| sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19 Fluvoxamine, Placebo - Post-COVID, POST-Covid 19 | Phase 3 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 160 | 2026-06-04 | 2026-06-09 |
| Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated Tracheobronchitis Optimized and protocolized nebulization procedure. - Ventilator-Associated Pneumonia, Ventilator-Associated Tracheobronchitis | Phase 3 | Not yet recruiting | University Hospital, Tours | 250 | 2026-06-01 | 2026-06-24 |
| Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Ketofol, propofol (drug) - The Critically Ill Patient is Requiring Intubation, Septic Shock | Phase 3 | Active not recruiting | Helwan University | 70 | 2026-05-13 | 2026-10-15 |
| Adaptive Platform Trial of Treatments for Respiratory Infections in Community Settings (TreatResp) Baloxavir, Placebo Control - Influenza A, Influenza B | Phase 3 | Recruiting | Unity Health Toronto | 264 | 2026-04-29 | 2026-08-18 |
| Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia Nogapendekin alfa inbakicept (NAI), agenT-797 - Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Withdrawn | ImmunityBio, Inc. | 2026-04-15 | 2026-05-08 | |
| Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia Icosapent Ethyl 1000 MG Oral Capsule [Vascepa], Placebo - Inflammation, Community Acquired Pneumonia (CAP) | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 168 | 2026-04-08 | 2026-05-11 |
| A Study of Human Umbilical Cord Blood (REGENECYTE) Infusion in Patients With Post-COVID Condition REGENECYTE, Placebo - Long COVID, Post-COVID-19 Condition | Phase 3 | Not yet recruiting | StemCyte, Inc. | 60 | 2026-03-31 | 2025-09-23 |
| Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Prior Pneumococcal Vaccination 31-valent pneumococcal conjugate vaccine, PCV20 - Pneumococcal Vaccines | Phase 3 | Active not recruiting | Vaxcyte, Inc. | 752 | 2026-02-09 | 2026-06-30 |
| Adaptive RCT of Corticosteroids for Severe Adenovirus Pneumonia in Adults Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone - Adenovirus Infections, Human | Phase 3 | Not yet recruiting | Qingyuan Zhan | 262 | 2026-02-01 | 2026-01-21 |
| Adaptive RCT of Corticosteroids for Severe Chlamydia Psittaci Pneumonia in Adults Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone - Psittacosis | Phase 3 | Not yet recruiting | Qingyuan Zhan | 100 | 2026-01-15 | 2026-01-20 |
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COVID-19 (909) · Coronavirus Infections (149) · Severe Acute Respiratory Syndrome (60) · Community-Acquired Pneumonia (55) · Pneumonia, Ventilator-Associated (55) · Respiratory Distress Syndrome (38) · Post-Acute COVID-19 Syndrome (33) · Virus Diseases (33) · Pneumonia, Bacterial (27) · Pneumonia, Pneumocystis (27) · Pneumonia, Viral (25) · Respiratory Tract Infections (25) · Healthcare-Associated Pneumonia (24) · Infections (22)
Respiratory Tract Diseases (1181) · Infections (1170) · Respiratory Tract Infections (1167) · Lung Diseases (1151) · RNA Virus Infections (945) · Virus Diseases (934) · Nidovirales Infections (919) · Coronaviridae Infections (917) · Pneumonia, Viral (913) · Coronavirus Infections (784) · Pathological Conditions, Signs and Symptoms (214) · Pathologic Processes (186) · Disease Attributes (119) · Bacterial Infections and Mycoses (86)
Hydroxychloroquine (79) · Standard of Care (63) · remdesivir (40) · Sodium Chloride (38) · Azithromycin (35) · BNT162 Vaccine (32) · Saline Solution (29) · Ivermectin (28) · favipiravir (24) · Dexamethasone (22) · 2019-nCoV Vaccine mRNA-1273 (20) · Methylprednisolone (18) · Trimethoprim, Sulfamethoxazole Drug Combination (18) · baricitinib (18) · COVID-19 Vaccines (16)
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PMID 34473343, PMID 35713300, PMID 35244208, PMID 36695483, PMID 37489818, PMID 34350582, PMID 37591523, PMID 33502773, PMID 32109013, PMID 32171076, PMID 34658014, PMID 35464483, PMID 35695334, PMID 36442063, PMID 25030060, PMID 30808293, PMID 31986264, PMID 32142651, PMID 32187464, PMID 32423584, PMID 32678530, PMID 32738928, PMID 33264556, PMID 33570583, PMID 33960817, PMID 34013969, PMID 34155899, PMID 37385888, PMID 38618926, PMID 39225478, PMID 15616839, PMID 18444848, PMID 18508226, PMID 19670912, PMID 20211892, PMID 20459721, PMID 21482570, PMID 23357290, PMID 24708675, PMID 24723282, PMID 25487791, PMID 26702925, PMID 27718118, PMID 29454592, PMID 30597021, PMID 32091533, PMID 32105632, PMID 32150748, PMID 32251768, PMID 32253318
2023 (13), U24TR001608 (8), 2018 (5), 2015 (4), 2016 (3), M01RR000070 (3), M01RR000750 (3), M01RR006022 (3), M01RR008084 (3), U10HD021373 (3), U10HD021385 (3), U10HD021397 (3), U10HD027853 (3), U10HD027856 (3), U10HD027871 (3)