20 completed, 15 unknown, 7 not yet recruiting, 3 terminated. 21 Not applicable, 6 Phase 1, 5 Phase 2, 3 Phase 4, 2 Phase 3.
Follow Perianal Fistula: new trials by email Literature Review of Perianal Fistula trials Research Report on Perianal Fistula
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease Mirikizumab, Fistula Tract Curettage and Closure - Crohn's Disease, Perianal Fistula | Phase 4 | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 50 | 2026-12-01 | 2026-08-24 |
| Open Fistulectomy vs. Laser Closure for Low Perianal Fistula Fistula-tract Laser Closure (FiLaC), Open Fistulectomy - Perianal Fistula, Fistula-in-Ano | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-10-01 | 2026-09-01 |
| FiLaC and PRGF-Endoret for Multi-recurrent Cryptoglandular Perianal Fistula (PLASMA Pilot Study) Laser ablation of fistula tract using 1000-µm radial fibre (Biolitec, 1470 nm, 12 W, continuous, 1 mm/s withdrawal). Internal opening closed with Vicryl 2/0 suture in all patients - Perianal Fistula | Not applicable | Not yet recruiting | Complejo Hospitalario Universitario de Santiago | 25 | 2026-10-01 | 2026-09-09 |
| Risankizumab for Refractory Perianal Fistulizing Crohn's Disease Risankizumab - Crohn Disease, Perianal Fistula | Phase 4 | Not yet recruiting | Yuki Horio | 25 | 2026-10-01 | 2026-10-19 |
| Laser Ablation Versus Conventional Fistulectomy for Uncomplicated Perianal Fistula Laser ablation, Conventional Open Fistulectomy - Perianal Fistula, Anal Fistula | Not applicable | Not yet recruiting | PNS Hafeez - Naval Hospital | 72 | 2026-07-01 | 2026-07-02 |
| The Impact of Perianal Disease on Patient's Sex Life Patient Reported Outcome Assessment (Questionnaires) - Perianal Crohn Disease, Perianal Fistula | Recruiting | AHEPA University Hospital | 60 | 2026-03-31 | 2026-04-09 | |
| Role of MRI in Perianal Fistula Diagnostic imaging (MRI) - Perianal Fistula | Not yet recruiting | Sohag University | 30 | 2026-03-15 | 2026-04-03 | |
| This Study Compares the Conventional Cutting Seton Technique and a GLUBRAN®-Coated Seton in High Perianal Fistula Treatment. The Study Aims to Determine Whether the GLUBRAN®-Coated Seton Improves Healing, Reduces Postoperative Pain and Recurrence, and Better Preserves Anal Continence. Glubran-coated Seton, Seton - Perianal Fistula | Not applicable | Active not recruiting | Kasr El Aini Hospital | 36 | 2026-01-11 | 2026-06-30 |
| Recurrence and Anal Fistula Patient Reported Outcomes Trial Perianal fistula surgical repair - Anal Fistula Surgery, Anal Fistula | Recruiting | National and Kapodistrian University of Athens | 100 | 2026-01-01 | 2026-03-19 | |
| Comparison Of Surgical Outcomes Between Ligation Of Intersphincteric Fistula Tract And Fistulotomy With Seton In Perianal Fistula Ligation of Intersphincteric Fistula Tract (LIFT), Fistulotomy with Seton Placement - Anal Fistula, Perianal Fistula | Not applicable | Completed | Islamabad Medical and Dental College | 100 | 2026-01-01 | 2026-06-03 |
| Comparing Three Surgical Techniques for the Treatment of Transsphincteric Perianal Fistula: (1) Traditional Fistulotomy (Lay Open), (2) Ligation of the Intersphincteric Tract (LIFT) With Adjunctive Endo Fistula Laser Ablation, and (3) Open LIFT Procedure Followed by LASER fistula lay open, LIFT plus LASER, open LIFT plus LASER - Perianal Fistula | Not applicable | Not yet recruiting | Alexandria University | 90 | 2025-11-20 | 2025-11-21 |
| Procedure-Specific Approach To Minimize Fistulaization of The Perianal Abscess Cavity After Surgical Drainage Non Packing of perianal abscess cavity after drainage, Packing of perianal abscess cavity after drainage - Perianal Fistula | Not applicable | Completed | Suez Canal University | 154 | 2024-07-10 | 2025-04-17 |
| Diagnostic Value of Recto-perineal Ultrasound in Perianal Fistula Perianal Fistula | Completed | Zagazig University | 93 | 2023-09-01 | 2024-03-18 | |
| Study of ExoFlo for the Treatment of Perianal Fistulas ExoFlo, Local injection of normal saline - Perianal Fistula, Crohn's Disease | Phase 1 / Phase 2 | Terminated | Direct Biologics, LLC | 5 | 2023-08-28 | 2026-08-11 |
| Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia Ultrasound guided Pudendal nerve block - Hemorrhoids, Anal Fissure and Fistula | Not applicable | Unknown | Nepal Mediciti Hospital | 60 | 2023-08-12 | 2023-11-09 |
| Semiflex Assisted Vacuum Therapy for Perianal Abscesses/Sinuses and Fistula: a Pilot Study Semiflex Dome Catheter System - Perianal Fistula, Perianal Fistula Due to Crohn's Disease | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 40 | 2023-04-14 | 2024-06-06 |
| Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases Regenerative therapy with SVF-PRP to supplement perianal surgery - Perianal Fistula, Perianal Crohn Disease | Unknown | Kantonsspital Winterthur KSW | 50 | 2023-01-25 | 2023-02-02 | |
| Comparative Accuracy of Transperineal Ultrasound (TPUS) Versus Magnetic Resonance Imaging (MRI) for the Assessment of Perianal Fistulae in Patients With Crohn's Disease (CD): a Prospective Observational Longitudinal Cohort Study A multicentric prospective observational longitudinal cohort study. - Crohn Disease, Perianal Fistula | Unknown | IRCCS San Raffaele | 50 | 2022-07-18 | 2023-02-10 | |
| A Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's Disease Human TH-SC01 cell injection - Perianal Fistula, Crohn's Disease | Phase 1 / Phase 2 | Completed | Jiangsu Topcel-KH Pharmaceutical Co., Ltd. | 9 | 2022-01-30 | 2025-04-01 |
| Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial Ciprofloxacin 500 mg, Metronidazole 500 mg, Placebo - Perianal Fistula, Perianal Abscess | Not applicable | Unknown | dr. IJM Han-Geurts | 298 | 2021-12-23 | 2023-11-13 |
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Crohn Disease (16) · Fissure in Ano (5) · Fistula (5) · Rectal Fistula (5) · Hemorrhoids (4) · Inflammatory Bowel Diseases (3) · Encopresis (1) · Pilonidal Sinus (1) · Rectovaginal Fistula (1) · Recurrence (1)
Digestive System Diseases (28) · Gastrointestinal Diseases (28) · Intestinal Diseases (28) · Gastroenteritis (18) · Inflammatory Bowel Diseases (15) · Pathological Conditions, Signs and Symptoms (10) · Rectal Diseases (10) · Pathological Conditions, Anatomical (9) · Digestive System Fistula (6) · Intestinal Fistula (6) · Anus Diseases (5) · Cardiovascular Diseases (4) · Fistula (4) · Vascular Diseases (4) · Behavior (1)
Ciprofloxacin (3) · Metronidazole (3) · Amoxicillin (1) · Bupivacaine (1) · Capsule Endoscopy (1) · Clavulanic Acid (1) · Doxycycline (1) · Injections (1) · Ketamine (1) · Laser Therapy (1) · Lasers (1) · Lifting (1) · Magnetic Resonance Spectroscopy (1) · Population Groups (1) · Portacaval Shunt, Surgical (1)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (3) · William A. Faubion, M.D. (2) · Zagazig University (2) · AHEPA University Hospital (1) · Alexandria University (1) · Anterogen Co., Ltd. (1) · Anthony Lembo (1) · Assiut University (1) · Avobis Bio, LLC (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Bikkur Holim Hospital (1) · Chinese University of Hong Kong (1) · Complejo Hospitalario Universitario de Santiago (1) · Consorci Sanitari de l'Alt Penedès i Garraf (1) · Direct Biologics, LLC (1)
United States (8) · Egypt (5) · Italy (5) · Netherlands (3) · Pakistan (3) · Switzerland (3) · Canada (2) · Greece (2) · Spain (2) · United Kingdom (2) · China (1) · Hong Kong (1) · Israel (1) · Japan (1) · Nepal (1)
Abdelrahman M. Ibrahim, M.D. (1) · Ahmed Y. Ahmed, M.D. (1) · Amy Lightner, MD (1) · Antonino Spinelli, MD, PhD (1) · Bill Arana (1) · DS Kim (1) · Damian Garcia-Olmo, Prof. (1) · Daniel Steinemann (1) · Eric J Dozois, M.D. (1) · Eric J Dozois, MD (1) · Gilberto Poggioli, Prof (1) · Gordon Moran, PhD,MD (1) · Ismail A Shafik, M.D. (1) · Jessica Gonzales, MD (1) · Joan Morris (1)
PMID 16181301, PMID 19755971, PMID 21083581, PMID 22223472, PMID 28211593, PMID 28453755, PMID 28489253, PMID 29096949, PMID 30772343, PMID 32187663, PMID 34819138, PMID 36351727, PMID 39473704, PMID 40072575, PMID 41359090, PMID 41879234