24 completed, 14 recruiting, 6 active not recruiting, 4 unknown. 27 Phase 2, 14 Not applicable, 8 Phase 1, 1 Phase 3.
Follow Penile Cancer: new trials by email Literature Review of Penile Cancer trials Research Report on Penile Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Becotatug Vedotin Combined With Pucotenlimab in the Treatment of EGFR-Positive Advanced Penile Cancer Becotatug Vedotin (recombinant humanized anti-EGFR mAb-MMAE conjugate) combined with Pucotenlimab (recombinant humanized anti-PD-1 mAb) - Penile Cancer | Phase 2 | Recruiting | Fudan University | 20 | 2026-09-01 | 2026-09-18 |
| Neoadjuvant Pucotenlimab and Becotatug Vedotin for Locally Advanced Penile Cancer Pucotenlimab plus Becotatug Vedotin - Penile Cancer, Penile Squamous Cell Carcinoma (PSCC) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 29 | 2026-08-15 | 2026-08-17 |
| EGFR-ADC (Becotatug Vedotin) Combined With PD-1 Inhibitor (Pucotenlimab) in Neoadjuvant Treatment of Advanced Penile Cancer Becotatug Vedotin, Pucotenlimab - Penile Cancer | Phase 2 | Recruiting | Jiyan Liu | 60 | 2026-07-22 | 2026-07-29 |
| QL1706 Plus Lenvatinib in Previously Treated Penile Cancer QL1706 + Lenvatinib - Penile Cancer | Phase 2 | Recruiting | Sun Yat-sen University | 47 | 2026-04-10 | 2026-05-08 |
| DEfeating PEnile CAncer-2 open inguinal lymphadenectomy, robot-assisted inguinal lymphadenectomy - Penile Cancer, Penile Neoplasms Malignant | Not applicable | Recruiting | University Hospital Tuebingen | 80 | 2026-04-10 | 2026-09-30 |
| MRG003 Plus HX008 as First-Line Treatment for EGFR-Positive Locally Advanced or Metastatic Penile Squamous Cell Carcinoma MRG003, HX008 - Penile Cancer | Phase 1 | Recruiting | Jiyan Liu | 10 | 2026-02-12 | 2026-04-07 |
| A PHASE II, RANDOMIZED STUDY TO ASSESS MAINTENANCE THERAPY WITH CEMIPLIMAB VERSUS BEST SUPPORTIVE CARE AFTER 1ST LINE PLATINUM-BASED CHEMOTHERAPY IN ADVANCED/RECURRENT PENILE CANCER Cemiplimab - Penile Cancer | Phase 2 | Not yet recruiting | Hospital Israelita Albert Einstein | 42 | 2025-12-01 | 2025-08-03 |
| E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers E7 TCR-T cells, Aldesleukin - HPV-Associated Cervical Carcinoma, HPV-Related Carcinoma | Phase 1 / Phase 2 | Recruiting | Christian Hinrichs | 15 | 2025-08-11 | 2026-10-06 |
| Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors Albumin-paclitaxel Injection - Paget Disease, Extramammary, Rhabdomyosarcoma | Phase 2 | Recruiting | Fudan University | 100 | 2024-11-30 | 2024-12-20 |
| Ivonescimab in the Treatment of Multiple Advanced Tumors Ivocizumab - Pheochromocytoma/Paraganglioma, Rhabdomyosarcoma | Phase 2 | Recruiting | Fudan University | 400 | 2024-11-20 | 2025-08-24 |
| Enhanced Assistance During Radiotherapy for Unmet Essential Needs Standard assistance, Enhanced assistance - Bone Cancer, Brain Cancer | Not applicable | Completed | Washington University School of Medicine | 33 | 2024-10-04 | 2025-08-26 |
| Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer Carboplatin/Paclitaxel, Pembrolizumab, Partial or total penectomy with inguinal and/or pelvic lymph node dissection - Urologic Neoplasms, Urogenital Neoplasms | Phase 2 | Recruiting | The Netherlands Cancer Institute | 27 | 2024-08-13 | 2025-12-08 |
| A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Hansenula Polymorpha), Placebo - Genital Wart, Penile Cancer | Phase 3 | Active not recruiting | Shanghai Bovax Biotechnology Co., Ltd. | 9000 | 2024-07-11 | 2024-12-12 |
| TIP Regimen Combined With Toripalimab Neoadjuvant Therapy for Locally Advanced Penile Cancer Paclitaxel + Ifosfamide + Cisplatin & Toripalimab - Penile Cancer | Phase 2 | Completed | Sun Yat-sen University | 25 | 2024-05-31 | 2026-10-13 |
| A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest Electromagnetic Guided Laparoscopy, Ultrasound - Urologic Cancer, Urologic Neoplasms | Not applicable | Completed | Brigham and Women's Hospital | 7 | 2023-08-30 | 2026-09-30 |
| SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas SCG142 TCR-T cells - Human Papillomavirus Associated Carcinomas, Cervical Cancer | Phase 1 | Recruiting | The Affiliated Hospital of Qingdao University | 18 | 2023-08-02 | 2024-08-09 |
| A Chatbot Intervention for Reducing HPV Vaccine Hesitancy Personalized Chatbot Intervention, Non-Personalized Chatbot Intervention, No Chatbot Control - Cervical Cancer, Anal Cancer | Not applicable | Completed | University of Maryland, College Park | 456 | 2023-07-26 | 2024-10-21 |
| Linking In With Advice and Supports for Men Impacted by Metastatic Cancer Physiotherapy, Dietitian Support, Nursing and Psychosocial - Survivorship, Prostate Cancer | Not applicable | Active not recruiting | University College Cork | 72 | 2023-05-08 | 2026-10-01 |
| Assessment of Patient Experience and Needs for Patients Undergoing Invasive Inguinal Lymph Node Procedures for Penile Cancer Quality of Life Questionnaires, Patient Educational Needs, Symptom Management - Penile Cancer | Suspended | M.D. Anderson Cancer Center | 20 | 2023-04-14 | 2026-08-14 | |
| Validation of ICG-99mTc-nanoscan as Hybrid Tracer for Sentinel Node Biopsy Sentinel node biopsy with either ICG-99mTc-nanoscan or 99mTc-nanoscan - Penile Cancer, Melanoma | Not applicable | Completed | The Netherlands Cancer Institute | 29 | 2023-04-01 | 2026-07-22 |
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Penile Neoplasms (53) · Anus Neoplasms (17) · Uterine Cervical Neoplasms (14) · Vaginal Neoplasms (10) · Prostatic Neoplasms (9) · Vulvar Neoplasms (9) · Testicular Neoplasms (8) · Head and Neck Neoplasms (7) · Kidney Neoplasms (7) · Oropharyngeal Neoplasms (7) · Urinary Bladder Neoplasms (6) · Esophageal Neoplasms (5) · Lung Neoplasms (4) · Melanoma (4) · Salivary Gland Neoplasms (4)
Genital Diseases (53) · Genital Diseases, Male (53) · Genital Neoplasms, Male (53) · Neoplasms by Site (53) · Penile Diseases (53) · Urogenital Diseases (53) · Male Urogenital Diseases (52) · Urogenital Neoplasms (51) · Neoplasms (50) · Female Urogenital Diseases (23) · Female Urogenital Diseases and Pregnancy Complications (23) · Digestive System Diseases (18) · Digestive System Neoplasms (18) · Gastrointestinal Diseases (18) · Gastrointestinal Neoplasms (18)
Cisplatin (4) · aldesleukin (4) · Ifosfamide (3) · Paclitaxel (3) · Adoptive Transfer (2) · Cyclophosphamide (2) · avelumab (2) · fludarabine (2) · fludarabine phosphate (2) · pembrolizumab (2) · Albumin-Bound Paclitaxel (1) · Alprostadil (1) · Biological Therapy (1) · CP protocol (1) · Docetaxel (1)
National Cancer Institute (NCI) (4) · Sun Yat-sen University (4) · The Netherlands Cancer Institute (4) · Fudan University (3) · Christian Hinrichs (2) · Jiyan Liu (2) · M.D. Anderson Cancer Center (2) · Shanghai Bovax Biotechnology Co., Ltd. (2) · The Affiliated Hospital of Qingdao University (2) · UNICANCER (2) · University of Maryland, College Park (2) · A.O.U. Città della Salute e della Scienza (1) · AIDS Malignancy Consortium (1) · Boston Medical Center (1) · Brigham and Women's Hospital (1)
United States (20) · China (13) · Netherlands (6) · France (4) · Belgium (2) · Italy (2) · United Kingdom (2) · Brazil (1) · Canada (1) · Finland (1) · Germany (1) · Hungary (1) · Ireland (1) · Norway (1) · Poland (1)
Christian S Hinrichs, MD (2) · Hongxia Wang, Doctor (2) · Xiaoli Nan (2) · Antti S Rannikko, MD, PhD (1) · Asif Muneer, MD (1) · Baris Karakullukcu, MD, PhD (1) · Barry L. Gause, MD (1) · Bradley A McGregor, MD (1) · Christian S Hinrichs, M.D. (1) · Christine Theodore, MD (1) · Christophe Le Tourneau, MD (1) · Curtis Pettaway, BS, MD (1) · Dingwei Ye (1) · Haitao Niu, PhD (1)
PMID 18417462, PMID 20625118, PMID 25823737, PMID 27160946, PMID 29149611, PMID 30125350, PMID 30658128, PMID 30714987, PMID 32620211, PMID 33216356, PMID 37487169, PMID 38558767, PMID 38600541, PMID 40588522, PMID 41468684, PMID 42757773
2018 (2), 2019 (2), 2014 (1), R01CA219060 (1), U01CA121947 (1), U01CA287904 (1), U10CA032102 (1)