87 completed, 49 recruiting, 23 terminated, 16 active not recruiting. 210 Phase 1, 70 Phase 2.
Follow Osteosarcoma: new trials by email Literature Review of Osteosarcoma trials Research Report on Osteosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors Chimeric Antigen Receptor (CAR) Therapy Infusion, Bevacizumab (Avastin) - Neuroblastoma (NBL), Ewing Sarcoma | Phase 1 | Not yet recruiting | Universität Münster | 30 | 2027-10-01 | 2026-11-03 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT EWSR1 immunotherapy, Pembrolizumab - Ewing Sarcoma, Desmoplastic Small Round Cell Tumor | Phase 1 | Not yet recruiting | Rabi Hanna | 24 | 2026-10-01 | 2026-09-17 |
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma Surgical Resection, Stereotactic Body Radiation Therapy (SBRT), Atezolizumab - Osteosarcoma, Pulmonary Recurrence of Osteosarcoma | Phase 1 | Recruiting | Emory University | 12 | 2026-10-01 | 2026-09-30 |
| A Study to Assess Safety and Efficacy of SOT106 in Patients With LRRC15-positive Advanced Unresectable or Metastatic Osteosarcoma or Soft Tissue Sarcoma SOT106 - Osteosarcoma Metastatic, Soft Tissue Sarcoma (STS) | Phase 1 / Phase 2 | Not yet recruiting | SOTIO Biotech a.s. | 70 | 2026-09-30 | 2026-09-03 |
| Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma Domatinostat, Sirolimus - Sarcoma, Osteosarcoma | Phase 1 / Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 74 | 2026-07-15 | 2026-09-03 |
| NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma i15.NKG2D.zeta NK cells and C7R.GD2.CARTs cells - Relapsed Neuroblastoma, Refractory Neuroblastoma | Phase 1 | Recruiting | Baylor College of Medicine | 27 | 2026-07-15 | 2026-07-21 |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS) Xaluritamig - Ewing Sarcoma | Phase 1 | Recruiting | Amgen | 50 | 2026-04-08 | 2026-10-29 |
| Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma Liposomal Irinotecan, Apatinib in arm1 - Osteosarcoma, Osteosarcoma Metastatic | Phase 1 / Phase 2 | Recruiting | Peking University People's Hospital | 56 | 2026-03-05 | 2026-03-18 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes Vincristine, Doxorubicin, Cyclophosphamide - Metastatic Ewing Sarcoma | Phase 1 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 15 | 2026-02-05 | 2026-09-25 |
| Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy) LNTH2403 Phase 1 dose, Phase 2; LNTH2403 a single agent recommended phase 2 dose (RP2D). - Relapsed / Refractory Osteosarcoma | Phase 1 / Phase 2 | Recruiting | Lantheus Medical Imaging | 55 | 2026-02-03 | 2026-05-01 |
| Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) Selective Antigen Specific dTβRII-expressing T cells combined with B7-H3 CAR T cells - Rhabdomyosarcoma, Ewing Sarcoma | Phase 1 | Recruiting | Children's National Research Institute | 18 | 2026-01-27 | 2026-08-13 |
| Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma Tegavivint, Gemcitabine - Osteosarcoma Recurrent, Osteosarcoma in Children | Phase 1 | Recruiting | Emory University | 24 | 2026-01-22 | 2026-10-19 |
| Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas Fludarabine, Cyclophosphamide, B7-H3-CAR T Cells - Sarcoma, Childhood Osteosarcoma | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 42 | 2026-01-21 | 2026-02-09 |
| Genetically Engineered Cells (FH-FOLR1 ST CAR T Cells) for the Treatment of Advanced Refractory or Recurrent/Progressive Osteosarcoma, FIERCe Trial FH FOLR1 ST CAR T-cells, Leukapheresis, Fludarabine - Advanced Osteosarcoma, Recurrent Osteosarcoma | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 30 | 2026-01-16 | 2026-09-01 |
Showing 20 of 210. Sign in to see all of them.
Sarcoma, Ewing (105) · Sarcoma (90) · Neuroblastoma (83) · Rhabdomyosarcoma (62) · Wilms Tumor (41) · Neoplasms (29) · Melanoma (28) · Neuroectodermal Tumors, Primitive, Peripheral (28) · Medulloblastoma (26) · Recurrence (21) · Sarcoma, Synovial (18) · Astrocytoma (16) · Carcinoma, Hepatocellular (16) · Carcinoma, Non-Small-Cell Lung (16)
Neoplasms by Histologic Type (210) · Neoplasms, Bone Tissue (210) · Neoplasms, Connective Tissue (210) · Neoplasms, Connective and Soft Tissue (209) · Neoplasms (181) · Sarcoma (120) · Neoplasms, Glandular and Epithelial (109) · Neoplasms, Nerve Tissue (108) · Neuroectodermal Tumors (101) · Neoplasms by Site (100) · Neoplasms, Neuroepithelial (96) · Neoplasms, Germ Cell and Embryonal (93) · Neuroectodermal Tumors, Primitive (85) · Neoplasms, Muscle Tissue (70) · Myosarcoma (64)
Cyclophosphamide (20) · Irinotecan (16) · Temozolomide (15) · Filgrastim (10) · Ifosfamide (10) · Gemcitabine (8) · Granulocyte Colony-Stimulating Factor (8) · fludarabine (8) · Etoposide (7) · Leucovorin (7) · Carboplatin (6) · Doxorubicin (6) · Methotrexate (6) · Topotecan (6) · Vincristine (6)
National Cancer Institute (NCI) (25) · St. Jude Children's Research Hospital (9) · Emory University (7) · Children's Oncology Group (6) · M.D. Anderson Cancer Center (6) · Peking University People's Hospital (5) · Baylor College of Medicine (4) · City of Hope Medical Center (4) · National Institutes of Health Clinical Center (CC) (4) · H. Lee Moffitt Cancer Center and Research Institute (3) · Memorial Sloan Kettering Cancer Center (3) · Seattle Children's Hospital (3) · University of Louisville (3) · AeRang Kim (2) · Ann & Robert H Lurie Children's Hospital of Chicago (2)
United States (166) · China (19) · Italy (16) · France (15) · Spain (15) · United Kingdom (15) · Canada (12) · Germany (11) · Australia (10) · Denmark (4) · South Korea (4) · Czechia (3) · Netherlands (3) · Poland (3) · Switzerland (3)
Holly Meany, MD (3) · Jonathan Metts, MD (3) · Matteo Trucco, MD (3) · Thomas Cash, MD, MSc (3) · AeRang Kim, MD, PhD (2) · Catherine Albert, MD (2) · Crystal L Mackall, M.D. (2) · Elizabeth Fox, MD (2) · Kelly Goldsmith, MD (2) · Kenneth Lucas, M.D. (2) · Kim Kramer, MD (2) · Theodore Laetsch, MD (2)
PMID 31401903, PMID 32192573, PMID 15814645, PMID 16234526, PMID 16551859, PMID 16914576, PMID 18048828, PMID 18281544, PMID 18391430, PMID 18470481, PMID 19075272, PMID 19430790, PMID 20036194, PMID 20044751, PMID 20226028, PMID 20407240, PMID 20460632, PMID 22186789, PMID 22682017, PMID 23071222, PMID 23255417, PMID 23382028, PMID 23664013, PMID 24089446, PMID 24711551, PMID 25452614, PMID 25917459, PMID 26154941, PMID 26181034, PMID 27109631, PMID 27932229, PMID 28183713, PMID 28295221, PMID 28494338, PMID 28735378, PMID 29544202, PMID 29931504, PMID 30410720, PMID 30477937, PMID 31013172, PMID 31553693, PMID 31838007, PMID 31876107, PMID 32169872, PMID 32554315, PMID 33047248, PMID 33203665, PMID 33289920, PMID 33305087, PMID 33364285
UM1CA228823 (5), 2023 (4), P30CA033572 (3), U01CA097452 (3), P30CA008748 (2), U01CA069856 (2), UM1CA097452 (2), 2016 (1), 2017 (1), 2018 (1), 2019 (1), K12CA120780 (1), N01CM62206 (1), P01CA094237 (1), P30CA014520 (1)