37 completed, 7 terminated, 2 unknown, 1 active not recruiting. 48 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 48 | Completed 37, Terminated 7, Unknown 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Active not recruiting 1, Terminated 1 |
Follow Optic Nerve Glioma: new trials by email Literature Review of Optic Nerve Glioma trials Research Report on Optic Nerve Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours Selumetinib - Neurofibromatosis Type 1, Plexiform Neurofibroma | Phase 1 / Phase 2 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 14 | 2019-09-26 | 2024-04-04 |
| Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Laboratory Biomarker Analysis, Pharmacological Study, Pomalidomide - Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2015-07-14 | 2022-04-25 |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
| Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors Photofrin (porfimer sodium) & photodynamic therapy. - Brain Tumor, Recurrent | Phase 1 | Completed | Harry T Whelan, MD | 5 | 2013-03-01 | 2019-02-25 |
| Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma imetelstat sodium, laboratory biomarker analysis, pharmacological study - Brain and Central Nervous System Tumors, Lymphoma | Phase 1 | Completed | Children's Oncology Group | 34 | 2011-05-01 | 2014-01-30 |
| PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors VEGF inhibitor PTC299 - Brain and Central Nervous System Tumors | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 28 | 2010-11-01 | 2015-05-04 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment pazopanib hydrochloride, pharmacological study - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2009-06-01 | 2013-09-30 |
| Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors carboplatin, dasatinib, etoposide phosphate - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 7 | 2008-09-10 | 2026-11-04 |
| MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer MK-0752 - Brain and Central Nervous System Tumors | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 33 | 2008-07-01 | 2012-03-06 |
| Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors enzastaurin hydrochloride - Brain and Central Nervous System Tumors, Neuroblastoma | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 32 | 2007-06-01 | 2012-03-06 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
| Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment talotrexin, chemotherapy - Brain and Central Nervous System Tumors, Leukemia | Phase 1 | Withdrawn | Children's Oncology Group | 2007-02-01 | 2014-08-08 | |
| Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade Glioma carboplatin, vinblastine sulfate - Brain and Central Nervous System Tumors, Neurofibromatosis Type 1 | Phase 1 | Completed | Children's Oncology Group | 26 | 2006-06-01 | 2014-02-13 |
| Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma ispinesib, laboratory biomarker analysis, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2006-06-01 | 2013-01-16 |
| AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Cediranib Maleate - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2006-03-01 | 2016-03-07 |
| Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors carboplatin, talabostat mesylate, temozolomide - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 26 | 2005-12-01 | 2012-03-15 |
Showing 20 of 48. Sign in to see all of them.
Astrocytoma (45) · Medulloblastoma (42) · Familial ependymoma (40) · Oligodendroglioma (32) · Choroid Plexus Neoplasms (31) · Central Nervous System Neoplasms (30) · Neuroblastoma (15) · Neuroectodermal Tumors, Primitive, Peripheral (14) · Rhabdoid Tumor (14) · Spinal Cord Neoplasms (12) · Wilms Tumor (12) · Dendritic Cell Sarcoma, Interdigitating (11) · Sarcoma (11) · Burkitt Lymphoma (10)
Cranial Nerve Diseases (48) · Cranial Nerve Neoplasms (48) · Eye Diseases (48) · Neoplasms by Histologic Type (48) · Neoplasms by Site (48) · Neoplasms, Glandular and Epithelial (48) · Neoplasms, Nerve Tissue (48) · Nervous System Diseases (48) · Nervous System Neoplasms (48) · Neuroectodermal Tumors (48) · Optic Nerve Diseases (48) · Optic Nerve Neoplasms (48) · Peripheral Nervous System Neoplasms (48) · Neoplasms, Germ Cell and Embryonal (47) · Neoplasms (46)
Filgrastim (9) · Carboplatin (8) · Temozolomide (8) · Etoposide (4) · Granulocyte Colony-Stimulating Factor (4) · Busulfan (3) · Ifosfamide (3) · Irinotecan (3) · O(6)-benzylguanine (3) · Peripheral Blood Stem Cell Transplantation (3) · Cyclophosphamide (2) · Melphalan (2) · Radiotherapy (2) · Topotecan (2) · Vincristine (2)
National Cancer Institute (NCI) (17) · Pediatric Brain Tumor Consortium (8) · Children's Oncology Group (6) · National Institutes of Health Clinical Center (CC) (3) · City of Hope Medical Center (2) · Children's Cancer and Leukaemia Group (1) · Daiichi Sankyo (1) · Duke University (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Harry T Whelan, MD (1) · Julie Krystal (1) · Masonic Cancer Center, University of Minnesota (1) · Medical College of Wisconsin (1) · Memorial Sloan Kettering Cancer Center (1) · OHSU Knight Cancer Institute (1)
United States (45) · Canada (7) · Australia (2) · United Kingdom (2) · Ireland (1)
Elizabeth Fox, MD (2) · Mark W. Kieran, MD, PhD (2) · Susan M. Blaney, MD (2) · AeRang Kim, MD (1) · Allen R. Chen, MD, PhD, MHS (1) · Amar Gajjar (1) · Anna Pawlowska, MD (1) · Barbara Jean Bambach, MD (1) · Darren Hargrave, MB Bch (1) · Darren Hargrave, MD (1) · Denise Adams, MD (1) · Edward A. Neuwelt, MD (1) · Elizabeth Lowe (1) · Eric Bouffet, MD, MRCP (1) · Harry T Whelan, MD (1)
PMID 15814645, PMID 16234526, PMID 16533779, PMID 16914576, PMID 17634493, PMID 17941066, PMID 18048828, PMID 18281544, PMID 18281546, PMID 19065567, PMID 19075272, PMID 19430790, PMID 20044751, PMID 20049936, PMID 20460632, PMID 21115653, PMID 21764821, PMID 23554030, PMID 23857966, PMID 9849694
U01CA081457 (9), U01CA097452 (8), P30CA033572 (1), UM1CA081457 (1)