112 completed, 26 unknown, 23 recruiting, 20 terminated. 58 Phase 1, 52 Phase 2, 50 Not applicable, 8 Phase 3, 6 Early Phase 1.
Follow Cranial Nerve Neoplasms: new trials by email Literature Review of Cranial Nerve Neoplasms trials Research Report on Cranial Nerve Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of ChatGPT in Vestibular Schwannoma Management Use of chatGPT for 1 week - Vestibular Schwannoma | Not applicable | Withdrawn | University of Southern California | 2027-01-01 | 2026-01-13 | |
| Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2 | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 20 | 2026-12-01 | 2026-10-28 |
| Luvometinib in Combination With Serplulimab for NF2-Related Tumors Luvometinib, Serplulimab - NF2-related Schwannomatosis, NF2 | Phase 1 / Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 30 | 2026-07-31 | 2026-07-16 |
| Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2) Selumetinib 25mg/m2, Luvometinib, Serplulimab - Neurofibromatosis Type 2, Vestibular Schwannoma | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-07-18 | 2026-07-20 |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Study to Determine Optimal Dose, Evaluate the Efficacy and Safety of PRG-N-01 in Patients With Neurofibromatosis Type II Trineumin - Neurofibromatosis Type II, NF2 | Phase 1 / Phase 2 | Not yet recruiting | PRG Science & Technology Co., Ltd. | 25 | 2026-07-01 | 2026-01-23 |
| Measuring Vestibular Organ Function With Weak Alternating Current Stimulation Active transcranial electrical vestibular stimulation (Active EVS), Sham transcranial electrical vestibular stimulation (Sham EVS), Control measurement - Vestibular Disorder, Vestibular Schwannoma | Not applicable | Enrolling by invitation | Aalto University | 30 | 2026-06-08 | 2026-07-01 |
| Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery Oliceridine, Sufentanil - PONV, Cerebellopontine Angle Tumor | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 174 | 2026-03-25 | 2026-05-22 |
| Long Term Follow-up Study of AAVAnc80-antiVEGF Gene Therapy Vestibular Schwannoma | Enrolling by invitation | Eli Lilly and Company | 100 | 2026-03-02 | 2026-11-04 | |
| Assessment of Patient Experience With Auto-Captioning Glasses in NF2-Related-Schwannomatosis Auto-captioning Glasses - NF2-related Schwannomatosis | Not applicable | Completed | Massachusetts General Hospital | 18 | 2026-02-19 | 2026-08-25 |
| Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients Steroids therapy, Placebo - Vestibular Schwannoma, Facial Nerve Paralysis | Phase 3 | Recruiting | Beijing Tiantan Hospital | 364 | 2025-10-09 | 2026-10-26 |
| 3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features Vestibular Schwannoma | Recruiting | Shengjing Hospital | 30 | 2025-09-25 | 2026-10-16 | |
| Vestibular Rehabilitation Protocol in Unilateral Vestibular Schwannoma No Intervention: Observational Cohort, Structured home-based vestibular telerehabilitation program, CE-marked clinical rotatory chair - Vestibular Schwannoma, Vestibular Schwannomas | Not applicable | Recruiting | Albert Torrents Torrero | 75 | 2025-09-01 | 2026-01-23 |
| Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma vestibular schwannoma resection - Vestibular Schwannoma, Unilateral Vestibular Deficit | Not applicable | Recruiting | Marketa Bonaventurova | 40 | 2025-06-01 | 2026-10-22 |
| Early Rehabilitation Using Head Impulse Test for Acute Vestibular Deficit Experimental treatment: Head movements, Sham treatment: only eye movements - Vestibular Schwannoma, Unilateral Vestibular Deficit | Not applicable | Recruiting | Hospices Civils de Lyon | 26 | 2025-05-13 | 2025-05-16 |
| Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma AAVAnc80-antiVEGF via Akouos Delivery Device - Vestibular Schwannoma | Phase 1 / Phase 2 | Recruiting | Eli Lilly and Company | 27 | 2025-01-17 | 2026-11-04 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| USPIO Enhanced MR Imaging in CNS Tumours (UMIC) USPIO enhanced MRI - Vestibular Schwannoma, Glioma, Astrocytic | Not applicable | Recruiting | Northern Care Alliance NHS Foundation Trust | 17 | 2024-04-26 | 2024-08-27 |
| Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery Vestibular exam - Vestibular Schwannoma, Neurinoma, Acoustic | Not applicable | Unknown | Centre Hospitalier Universitaire de Besancon | 20 | 2024-02-20 | 2024-09-19 |
| Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas Microsurgical resection of VS, Stereotactic radiosurgery, PREHAB - Vestibular Schwannoma | Not applicable | Recruiting | Medical College of Wisconsin | 36 | 2024-01-22 | 2026-03-24 |
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Neuroma, Acoustic (98) · Optic Nerve Glioma (82) · Astrocytoma (77) · Medulloblastoma (58) · Oligodendroglioma (57) · Familial ependymoma (55) · Central Nervous System Neoplasms (49) · Neurofibromatosis 2 (47) · Choroid Plexus Neoplasms (43) · Meningioma (28) · Brain Neoplasms (26) · Neuroblastoma (23) · Ependymoma (19) · Neuroectodermal Tumors, Primitive, Peripheral (19) · Sarcoma (19)
Cranial Nerve Diseases (207) · Nervous System Diseases (206) · Neoplasms by Histologic Type (203) · Neoplasms, Nerve Tissue (203) · Neuroectodermal Tumors (203) · Neoplasms (200) · Neoplasms, Germ Cell and Embryonal (200) · Neoplasms by Site (189) · Nervous System Neoplasms (186) · Peripheral Nervous System Neoplasms (183) · Neuroendocrine Tumors (130) · Nerve Sheath Neoplasms (129) · Otorhinolaryngologic Neoplasms (125) · Otorhinolaryngologic Diseases (123)
Carboplatin (13) · Temozolomide (12) · Filgrastim (9) · Bevacizumab (8) · Radiosurgery (7) · Etoposide (6) · Radiotherapy (6) · Vincristine (5) · AZD 6244 (4) · Cochlear Implants (4) · Everolimus (4) · Granulocyte Colony-Stimulating Factor (4) · Irinotecan (4) · Busulfan (3) · Gentamicins (3)
National Cancer Institute (NCI) (27) · Children's Oncology Group (12) · Pediatric Brain Tumor Consortium (8) · Massachusetts Eye and Ear Infirmary (6) · Massachusetts General Hospital (6) · Beijing Tiantan Hospital (5) · NYU Langone Health (5) · Children's Cancer and Leukaemia Group (3) · Duke University (3) · Medical University of Vienna (3) · Memorial Sloan Kettering Cancer Center (3) · National Institutes of Health Clinical Center (CC) (3) · University Hospital Tuebingen (3) · Washington University School of Medicine (3) · Assistance Publique - Hôpitaux de Paris (2)
United States (130) · Canada (18) · France (17) · United Kingdom (11) · China (10) · Australia (8) · Switzerland (8) · Puerto Rico (7) · Austria (6) · Netherlands (6) · New Zealand (6) · Germany (4) · Italy (4) · Norway (3) · Sweden (3)
Ana-Maria Vranceanu, PhD (3) · Elizabeth Fox, MD (3) · Henry S. Friedman, MD (3) · Matthias A Karajannis, MD, MS (3) · Aaron Tward, MD (2) · D. Bradley Welling, MD, PhD (2) · Fu Zhao (2) · Harry T Whelan, MD (2) · Katherine Warren, MD (2) · Kim Kramer, MD (2) · Laura Fariselli, MD (2) · Mark W. Kieran, MD, PhD (2) · Maryam Fouladi (2) · Matthew L Carlson, MD (2)
PMID 17917842, PMID 19574236, PMID 19645909, PMID 22027076, PMID 10449559, PMID 11587600, PMID 11710496, PMID 11981398, PMID 12925338, PMID 12943357, PMID 14724495, PMID 15354006, PMID 15519876, PMID 15814645, PMID 16234526, PMID 16408203, PMID 16533779, PMID 16914576, PMID 17438254, PMID 17562049, PMID 17610262, PMID 17634493, PMID 17941066, PMID 18048828, PMID 18281544, PMID 18281546, PMID 18607963, PMID 18769654, PMID 18989154, PMID 19065567, PMID 19075272, PMID 19430790, PMID 19645932, PMID 20044751, PMID 20049936, PMID 20381270, PMID 20460632, PMID 20592851, PMID 20592852, PMID 20802221, PMID 20851113, PMID 21115653, PMID 21764821, PMID 22665535, PMID 23554030, PMID 23573135, PMID 23857966, PMID 24321536, PMID 24904885, PMID 25745609
U01CA081457 (9), U01CA097452 (8), U10CA098543 (6), U10CA081920 (2), 2005 (1), 2017 (1), P30CA006973 (1), P30CA008748 (1), P30CA012197 (1), P30CA013148 (1), P30CA033572 (1), P30CA086862 (1), P30CA124435 (1), R01DC003196 (1), R01DC012593 (1)