8165 completed, 1634 unknown, 1314 recruiting, 589 active not recruiting. 7702 Not applicable, 932 Phase 2, 748 Phase 1, 652 Phase 3, 568 Phase 4.
Follow Obesity: new trials by email Literature Review of Obesity trials Research Report on Obesity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Metabolic Effects of Polylactose: A Novel Prebiotic Polylactose, Placebo - Obesity, Adolescent, Obesity, Childhood | Not applicable | Withdrawn | University of Minnesota | 2028-05-01 | 2025-07-11 | |
| A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults Body positioning - Healthy Volunteers Only | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 20 | 2028-01-01 | 2025-06-18 |
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| Community Active and Healthy Families Pragmatic Trial Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment - Child Obesity | Phase 4 | Not yet recruiting | University of Colorado, Denver | 416 | 2028-01-01 | 2026-10-09 |
| AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH AI-informed behavioral intervention, Standard behavioral intervention, Health Education - Obesity (Disorder) | Not applicable | Not yet recruiting | Aikaterini Karaivazoglou | 840 | 2027-09-01 | 2026-04-14 |
| Modifying Diet to Improve Gut Microbiome DASH diet, standard American diet - Obesity | Not applicable | Not yet recruiting | H. Lee Moffitt Cancer Center and Research Institute | 28 | 2027-07-01 | 2026-09-17 |
| Simplifying Diet Tracking in a Digital Weight Loss Intervention Simplified Dietary Self-Monitoring, Detailed Dietary Self-Monitoring, Core Behavioral Weight Loss Intervention - Overweight, Obesity | Not applicable | Not yet recruiting | Stanford University | 328 | 2027-05-01 | 2026-05-28 |
| Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D) ESG with OverStitch - Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30) | Not applicable | Not yet recruiting | Boston Scientific Corporation | 50 | 2027-04-01 | 2026-10-23 |
| Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? NutriAct plus, Rescue VLCD - Obesity & Overweight, Weight Loss Maintenance | Not applicable | Not yet recruiting | Knut Mai | 292 | 2027-03-01 | 2026-07-20 |
| Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose Pecan, Control - Nutrition, Healthy, Dyslipidemia | Not applicable | Not yet recruiting | University of Georgia | 90 | 2027-03-01 | 2026-08-11 |
| Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults LUM-201, Placebo, Semagludtide - Obesity & Overweight | Phase 2 | Not yet recruiting | Lumos Pharma | 202 | 2027-02-15 | 2026-08-10 |
| BRE-13: Mediterranean Diet Explore the effect of MedDiet vs. Usual Diet on Fatty Acid Profile, Explore the effect of MedDiet vs. Usual Diet on Breast Tumor Tissue, Explore the effect of MedDiet vs. Usual Diet on Lipids - Dietary Assessment, Dietary and Lifestyle Behaviour Change | Not applicable | Not yet recruiting | University of Illinois at Chicago | 30 | 2027-02-15 | 2026-10-09 |
| Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients Tirzepatide - Obesity / Overweight | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 80 | 2027-02-01 | 2026-10-15 | |
| Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 250 | 2027-02-01 | 2026-07-28 |
| EMBodied psychOsocial Impacts of Weight Stigma During Pregnancy (EMBODY): A Prospective Cohort Study Weight Stigma, Pregnancy Outcomes | Not yet recruiting | Monash University | 800 | 2027-02-01 | 2026-10-16 | |
| Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass One-anastomosis gastric bypass with observed biliopancreatic limb length - Obesity, Severe Obesity | Not yet recruiting | The Society of Bariatric and Metabolic Surgeons of Kazakhstan | 120 | 2027-01-15 | 2026-09-14 | |
| AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight Zenagamtide, Placebo ( matched to Zenagamtide) - Obesity, Overweight | Phase 3 | Not yet recruiting | Novo Nordisk A/S | 400 | 2027-01-07 | 2026-08-24 |
| Target Physiotherapy Versus Exercise Support Intervention for Bladder-bowel Dysfunction in Adolescents With Obesity Target physiotherapy, Exercise support intervention, Usual obesity care - Bladder-Bowel Dysfunction, Obesity & Overweight | Not applicable | Not yet recruiting | University of Lisbon | 237 | 2027-01-04 | 2026-07-23 |
| Addressing Food Access and Physical Activity to Improve Diabetes Prevention Outcomes Among Underserved African Americans Culturally-tailored, enhanced adaption of Diabetes Prevention Program - Diabetes, Physical Activity | Not applicable | Not yet recruiting | University of Missouri, Kansas City | 408 | 2027-01-04 | 2026-06-09 |
| Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access Semaglutide, Virtual Weight Management Coaching - Obesity, Chronic Kidney Disease | Phase 4 | Not yet recruiting | Kristin Clemens | 880 | 2027-01-01 | 2026-10-05 |
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Overweight (3043) · Weight Loss (1170) · Pediatric Obesity (1121) · Motor Activity (1109) · Diabetes Mellitus, Type 2 (1075) · Obesity, Morbid (931) · Diabetes Mellitus (803) · Insulin Resistance (751) · Metabolic Syndrome (699) · Hypertension (571) · Cardiovascular Diseases (470) · Inflammation (308) · Obesity, Abdominal (289) · Body Weight (285)
Nutritional and Metabolic Diseases (13154) · Overnutrition (13135) · Nutrition Disorders (13072) · Pathological Conditions, Signs and Symptoms (13052) · Signs and Symptoms (13017) · Body Weight (12721) · Overweight (10131) · Metabolic Diseases (3138) · Glucose Metabolism Disorders (2964) · Endocrine System Diseases (2157) · Behavior (2015) · Hyperinsulinism (1305) · Body Weight Changes (1299) · Diabetes Mellitus (1179)
Exercise (476) · Diet (231) · semaglutide (216) · Bariatric Surgery (163) · Tirzepatide (143) · Liraglutide (121) · Metformin (117) · Gastric Bypass (116) · Caloric Restriction (105) · Nutrition Assessment (95) · Control Groups (85) · Resistance Training (79) · Diet Therapy (77) · Sodium Chloride (72) · Standard of Care (71)
Novo Nordisk A/S (204) · University of Colorado, Denver (117) · Eli Lilly and Company (116) · Mayo Clinic (111) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (103) · The Miriam Hospital (90) · Washington University School of Medicine (89) · Pennington Biomedical Research Center (88) · University of Copenhagen (85) · Maastricht University Medical Center (84) · University of Alabama at Birmingham (84) · Massachusetts General Hospital (82) · Yale University (81) · Duke University (80) · University of Pennsylvania (79)
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PMID 38375882, PMID 33512717, PMID 29718281, PMID 38376518, PMID 26210388, PMID 30122305, PMID 26708836, PMID 28386912, PMID 28950422, PMID 30230252, PMID 30651576, PMID 33238176, PMID 33782940, PMID 38271099, PMID 40839263, PMID 41029405, PMID 42014131, PMID 22085317, PMID 23987123, PMID 24500151, PMID 26599819, PMID 27482610, PMID 27817208, PMID 28473337, PMID 31004409, PMID 32002540, PMID 32909523, PMID 33567185, PMID 37652841, PMID 38698650, PMID 39226070, PMID 39952695, PMID 40705619, PMID 11832527, PMID 15479938, PMID 17715408, PMID 18673303, PMID 19858703, PMID 20573639, PMID 21932999, PMID 22963820, PMID 23661689, PMID 23703580, PMID 24570244, PMID 24586896, PMID 25343235, PMID 26132939, PMID 26418188, PMID 26589105, PMID 26609668
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