Obesity: Clinical Trials

8187 completed, 1629 unknown, 1310 recruiting, 592 active not recruiting. 7712 Not applicable, 934 Phase 2, 749 Phase 1, 653 Phase 3, 570 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	7712	Completed 4992, Unknown 956, Recruiting 677, Active not recruiting 328, Not yet recruiting 285, Terminated 250, Withdrawn 151, Enrolling by invitation 62, Suspended 11
Phase 2	934	Completed 573, Recruiting 97, Unknown 64, Active not recruiting 58, Terminated 58, Not yet recruiting 42, Withdrawn 36, Enrolling by invitation 3, Suspended 3
Phase 1	749	Completed 482, Recruiting 105, Active not recruiting 46, Not yet recruiting 37, Terminated 30, Unknown 30, Withdrawn 17, Enrolling by invitation 1, Suspended 1
Phase 3	653	Completed 364, Recruiting 86, Unknown 57, Terminated 46, Active not recruiting 43, Not yet recruiting 38, Withdrawn 16, Suspended 2, Enrolling by invitation 1
Phase 4	570	Completed 322, Unknown 80, Recruiting 50, Not yet recruiting 37, Terminated 32, Active not recruiting 24, Withdrawn 20, Enrolling by invitation 4, Suspended 1
Early Phase 1	118	Completed 61, Unknown 15, Recruiting 13, Withdrawn 9, Active not recruiting 6, Not yet recruiting 5, Terminated 5, Suspended 3, Enrolling by invitation 1

Follow Obesity: new trials by email Literature Review of Obesity trials Research Report on Obesity

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Evaluating the Metabolic Effects of Polylactose: A Novel Prebiotic Polylactose, Placebo - Obesity, Adolescent, Obesity, Childhood	Not applicable	Withdrawn	University of Minnesota		2028-05-01	2025-07-11
A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults Body positioning - Healthy Volunteers Only	Not applicable	Not yet recruiting	Maurizio F. Cereda, MD	20	2028-01-01	2025-06-18
Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity	Not applicable	Not yet recruiting	Maurizio F. Cereda, MD	80	2028-01-01	2025-06-13
Community Active and Healthy Families Pragmatic Trial Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment - Child Obesity	Phase 4	Not yet recruiting	University of Colorado, Denver	416	2028-01-01	2026-10-09
Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients Tirzepatide + Standard Therapy (Intervention Group), Standard Oral Antidiabetic Drugs (OADs) - Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight	Not applicable	Not yet recruiting	Akhtar Saeed Medical and Dental College	52	2027-12-12	2026-10-29
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH AI-informed behavioral intervention, Standard behavioral intervention, Health Education - Obesity (Disorder)	Not applicable	Not yet recruiting	Aikaterini Karaivazoglou	840	2027-09-01	2026-04-14
Modifying Diet to Improve Gut Microbiome DASH diet, standard American diet - Obesity	Not applicable	Not yet recruiting	H. Lee Moffitt Cancer Center and Research Institute	28	2027-07-01	2026-09-17
Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression	Phase 2	Not yet recruiting	George Washington University	100	2027-05-15	2026-10-29
Simplifying Diet Tracking in a Digital Weight Loss Intervention Simplified Dietary Self-Monitoring, Detailed Dietary Self-Monitoring, Core Behavioral Weight Loss Intervention - Overweight, Obesity	Not applicable	Not yet recruiting	Stanford University	328	2027-05-01	2026-05-28
Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D) ESG with OverStitch - Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30)	Not applicable	Not yet recruiting	Boston Scientific Corporation	50	2027-04-01	2026-10-23
Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? NutriAct plus, Rescue VLCD - Obesity & Overweight, Weight Loss Maintenance	Not applicable	Not yet recruiting	Knut Mai	292	2027-03-01	2026-07-20
Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose Pecan, Control - Nutrition, Healthy, Dyslipidemia	Not applicable	Not yet recruiting	University of Georgia	90	2027-03-01	2026-08-11
Puerto Rican Obesity Intervention for Men TeleSalud Healthy Eating- Physical Activity/Sedentary Behavior (HE-PA/SB), TeleSalud General Health Intervention - Obesity	Not applicable	Not yet recruiting	Medical College of Wisconsin	48	2027-03-01	2026-10-30
Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults LUM-201, Placebo, Semagludtide - Obesity & Overweight	Phase 2	Not yet recruiting	Lumos Pharma	202	2027-02-15	2026-08-10
BRE-13: Mediterranean Diet Explore the effect of MedDiet vs. Usual Diet on Fatty Acid Profile, Explore the effect of MedDiet vs. Usual Diet on Breast Tumor Tissue, Explore the effect of MedDiet vs. Usual Diet on Lipids - Dietary Assessment, Dietary and Lifestyle Behaviour Change	Not applicable	Not yet recruiting	University of Illinois at Chicago	30	2027-02-15	2026-10-09
Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients Tirzepatide - Obesity / Overweight		Not yet recruiting	Nanjing First Hospital, Nanjing Medical University	80	2027-02-01	2026-10-15
Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30)	Phase 2	Not yet recruiting	Washington University School of Medicine	250	2027-02-01	2026-07-28
EMBodied psychOsocial Impacts of Weight Stigma During Pregnancy (EMBODY): A Prospective Cohort Study Weight Stigma, Pregnancy Outcomes		Not yet recruiting	Monash University	800	2027-02-01	2026-10-16
Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass One-anastomosis gastric bypass with observed biliopancreatic limb length - Obesity, Severe Obesity		Not yet recruiting	The Society of Bariatric and Metabolic Surgeons of Kazakhstan	120	2027-01-15	2026-09-14
AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight Zenagamtide, Placebo ( matched to Zenagamtide) - Obesity, Overweight	Phase 3	Not yet recruiting	Novo Nordisk A/S	400	2027-01-07	2026-08-24

Showing 20 of 13195. Sign in to see all of them.

Narrower conditions

Overweight (3056)  ·  Weight Loss (1175)  ·  Pediatric Obesity (1121)  ·  Motor Activity (1110)  ·  Diabetes Mellitus, Type 2 (1076)  ·  Obesity, Morbid (931)  ·  Diabetes Mellitus (804)  ·  Insulin Resistance (751)  ·  Metabolic Syndrome (699)  ·  Hypertension (571)  ·  Cardiovascular Diseases (471)  ·  Inflammation (308)  ·  Obesity, Abdominal (289)  ·  Body Weight (285)

Broader conditions

Nutritional and Metabolic Diseases (13175)  ·  Overnutrition (13156)  ·  Nutrition Disorders (13093)  ·  Pathological Conditions, Signs and Symptoms (13073)  ·  Signs and Symptoms (13038)  ·  Body Weight (12742)  ·  Overweight (10139)  ·  Metabolic Diseases (3140)  ·  Glucose Metabolism Disorders (2966)  ·  Endocrine System Diseases (2159)  ·  Behavior (2017)  ·  Body Weight Changes (1305)  ·  Hyperinsulinism (1305)  ·  Diabetes Mellitus (1180)

Interventions

Exercise (477)  ·  Diet (231)  ·  semaglutide (217)  ·  Bariatric Surgery (163)  ·  Tirzepatide (145)  ·  Liraglutide (121)  ·  Metformin (117)  ·  Gastric Bypass (116)  ·  Caloric Restriction (106)  ·  Nutrition Assessment (95)  ·  Control Groups (85)  ·  Resistance Training (79)  ·  Diet Therapy (77)  ·  Sodium Chloride (72)  ·  Standard of Care (71)

Sponsors

Novo Nordisk A/S (204)  ·  Eli Lilly and Company (117)  ·  University of Colorado, Denver (117)  ·  Mayo Clinic (112)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (103)  ·  The Miriam Hospital (90)  ·  Washington University School of Medicine (89)  ·  Pennington Biomedical Research Center (88)  ·  University of Copenhagen (85)  ·  Maastricht University Medical Center (84)  ·  University of Alabama at Birmingham (84)  ·  Massachusetts General Hospital (82)  ·  Yale University (81)  ·  Duke University (80)  ·  University of Pennsylvania (79)

Countries

United States (5408)  ·  Canada (631)  ·  China (619)  ·  France (563)  ·  United Kingdom (494)  ·  Spain (456)  ·  Turkey (Türkiye) (429)  ·  Italy (393)  ·  Denmark (384)  ·  Germany (356)  ·  Brazil (316)  ·  Netherlands (278)  ·  Mexico (235)  ·  Egypt (223)  ·  Sweden (219)

Top investigators

Samuel Klein, MD (22)  ·  Jack A Yanovski, M.D. (20)

Results publications

PMID 38375882, PMID 33512717, PMID 29718281, PMID 38376518, PMID 26210388, PMID 30122305, PMID 26708836, PMID 28386912, PMID 28950422, PMID 30230252, PMID 30651576, PMID 33238176, PMID 33782940, PMID 38271099, PMID 40839263, PMID 41029405, PMID 42014131, PMID 22085317, PMID 23987123, PMID 24500151, PMID 26599819, PMID 27482610, PMID 27817208, PMID 28473337, PMID 31004409, PMID 32002540, PMID 32909523, PMID 33567185, PMID 37652841, PMID 38698650, PMID 39226070, PMID 39952695, PMID 40705619, PMID 11832527, PMID 15479938, PMID 17715408, PMID 18673303, PMID 19858703, PMID 20573639, PMID 21932999, PMID 22963820, PMID 23661689, PMID 23703580, PMID 24570244, PMID 24586896, PMID 25343235, PMID 26132939, PMID 26418188, PMID 26589105, PMID 26609668

NIH funding

2025 (54), 2023 (36), 2017 (26), 2019 (22), 2018 (16), 2014 (15), 2015 (15), 2016 (14), 2009 (13), 2008 (10), UL1TR001082 (9), P50MD017338 (6), R01DK059853 (6), UL1TR000135 (6), 2005 (5)