12 completed, 2 not yet recruiting, 2 unknown, 1 enrolling by invitation. 20 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 12, Not yet recruiting 2, Unknown 2, Enrolling by invitation 1, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Nicotine Dependence, Cigarettes: new trials by email Literature Review of Nicotine Dependence, Cigarettes trials Research Report on Nicotine Dependence, Cigarettes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access - Nicotine Dependence, Cigarettes | Not applicable | Not yet recruiting | State University of New York at Buffalo | 100 | 2026-08-24 | 2026-08-06 |
| Effects of Nicotine Dependence on Multidimensional Health Outcomes Comprehensive Clinical Assessment - Tobacco Use Disorder, Nicotine Dependence, Cigarettes | Not applicable | Not yet recruiting | Izmir Democracy University | 212 | 2026-04-15 | 2026-03-16 |
| Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients Application of GLP-1RAs drugs, DPP-4i group - Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes | Not applicable | Enrolling by invitation | Shanghai East Hospital | 46 | 2025-06-21 | 2025-05-31 |
| Cigarette Harm Reduction With Electronic Cigarette Use SREC - Nicotine Dependence, Tobacco Toxicity | Not applicable | Withdrawn | University of California, San Francisco | 2022-08-01 | 2022-12-09 | |
| The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments Quit Card Intervention (QCI) - Nicotine Dependence, Cigarettes, Nicotine Withdrawal | Not applicable | Recruiting | Ottawa Heart Institute Research Corporation | 1208 | 2022-04-19 | 2026-11-04 |
| Re-Connect Application for Smoking Cessation Abstinent Contingent (AC) Re-Connect - Smoking Cessation, Acceptability of Health Care | Not applicable | Completed | Rowan University | 9 | 2021-12-14 | 2026-09-02 |
| Acute Oral Effects of Heated Tobacco Products IQOS 3.0 DOU with bland taste unit (Heated Tobacco Product), IQOS 3.0 DUO with menthol taste unit (Heated Tobacco Product), Marlboro Gold (Conventional cigarette) - Nicotine Dependence, Cigarettes | Not applicable | Completed | Semmelweis University | 10 | 2021-10-01 | 2023-11-27 |
| Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior Nicotine Corrective Messages - Nicotine Dependence, Cigarettes | Not applicable | Completed | University of Vermont | 794 | 2021-02-12 | 2022-12-02 |
| Evaluation of LLLT/Music for Smoking Cessation Fully Active, LLLT Only, Music Only - Nicotine Dependence, Cigarettes | Not applicable | Completed | Freedom Laser, Inc. | 28 | 2020-07-01 | 2021-04-05 |
| Improving Smoking Cessation in Socioeconomically-Disadvantaged Young Adults Web + text smoking cessation intervention - Nicotine Dependence, Cigarettes | Not applicable | Completed | University of Vermont | 437 | 2020-04-21 | 2021-02-11 |
| Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods. JUUL Virginia Tobacco flavored 5.0% ENDS, PMI iQOS Heat sticks, Reynolds VUSE Solo ENDS - Original - Nicotine Dependence, Nicotine Dependence, Cigarettes | Not applicable | Completed | Juul Labs, Inc. | 25 | 2018-12-04 | 2021-06-14 |
| United States Pre-Market Tobacco Application Pharmacokinetics Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS - Nicotine Dependence, Nicotine Dependence, Cigarettes | Not applicable | Completed | Juul Labs, Inc. | 67 | 2018-10-19 | 2021-06-14 |
| Reducing Nicotine Addiction in Adolescent Smokers Board Game, Tobacco Cesseation Education, Combined İntervention - Nicotine Dependence, Cigarettes, Cessation, Tobacco | Not applicable | Completed | Ministry of National Education, Turkey | 103 | 2018-09-03 | 2022-07-28 |
| Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers Tobacco flavored JUUL 1.7% ENDS, Tobacco flavored JUUL 5% ENDS, Mint flavored JUUL 1.7% ENDS - Nicotine Dependence, Nicotine Dependence, Cigarettes | Not applicable | Completed | Juul Labs, Inc. | 24 | 2018-06-29 | 2021-06-21 |
| Negotiating a Quit Date or Not in Online Interventions Endre: a digital smoking cessation counsellor - Nicotine Dependence, Cigarettes | Not applicable | Unknown | University of Oslo | 1500 | 2017-09-12 | 2021-10-08 |
| Online Lapse Management Intervention Endre: a digital smoking cessation counsellor, Lapse management system triggered from web-page, Lapse management system triggered by SMS-textmessage - Nicotine Dependence, Cigarettes | Not applicable | Unknown | University of Oslo | 1500 | 2017-09-12 | 2021-10-08 |
| Helping Poor Smokers Quit Specialized Quitline, Basic Needs Navigator - Smoking Cessation, Smoking, Tobacco | Not applicable | Completed | Washington University School of Medicine | 1944 | 2017-06-05 | 2023-12-26 |
| Epidemiology and Acute Oral Effects Electronic Cigarette ProVari v2.5 (E-cigarette), Marlboro Gold (Conventional cigarette), Cigarette tip - Nicotine Dependence, Cigarettes | Not applicable | Completed | Semmelweis University | 14 | 2015-09-01 | 2023-11-29 |
| Penn State TXT2Quit Study Motivational Text Messages, Control - Nicotine Dependence, Cigarettes | Not applicable | Completed | Milton S. Hershey Medical Center | 152 | 2015-01-01 | 2017-06-15 |
| Penn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay Quit Motivational Text Messages, Control - Nicotine Dependence, Cigarettes | Not applicable | Terminated | Milton S. Hershey Medical Center | 158 | 2013-12-01 | 2018-12-19 |
Tobacco Use Disorder (20) · Smoking Cessation (6) · Vaping (5) · Tobacco Smoking (4) · Tobacco Use (4) · Smoking (2) · Tobacco Use Cessation (2) · Behavior, Addictive (1) · Cigarette Smoking (1) · Diabetes Mellitus, Type 2 (1) · Emergencies (1) · Patient Acceptance of Health Care (1) · Pipe Smoking (1)
Chemically-Induced Disorders (20) · Mental Disorders (20) · Substance-Related Disorders (20) · Behavior (11) · Health Behavior (6) · Smoking (5) · Compulsive Behavior (1) · Diabetes Mellitus (1) · Disease Attributes (1) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1) · Impulsive Behavior (1) · Metabolic Diseases (1) · Nutritional and Metabolic Diseases (1) · Pathologic Processes (1)
Juul Labs, Inc. (3) · Milton S. Hershey Medical Center (2) · Semmelweis University (2) · University of Oslo (2) · University of Vermont (2) · Freedom Laser, Inc. (1) · Izmir Democracy University (1) · Ministry of National Education, Turkey (1) · Ottawa Heart Institute Research Corporation (1) · Rowan University (1) · Shanghai East Hospital (1) · State University of New York at Buffalo (1) · University of California, San Francisco (1) · Washington University School of Medicine (1)
United States (10) · Czechia (2) · New Zealand (2) · Norway (2) · Turkey (Türkiye) (2) · Canada (1) · China (1) · Hungary (1)
Andrea C Villanti, PhD, MPH (2) · Adam Bodian, MD (1) · Bethany Raiff, PhD (1) · Christopher Wynne, MD (1) · Concetta Carbonaro (1) · Eunhee Park, PhD, RN (1) · Jonathan Foulds, PhD (1) · Kerri-Anne Mullen, PhD (1) · Matthew Kreuter, PhD (1) · Neal L. Benowitz, MD (1) · Raymond Blanche (1) · Rebecca Settar, RN (1)
PMID 11206655, PMID 11298764, PMID 11738084, PMID 1370102, PMID 17712795, PMID 19165417, PMID 19750233, PMID 21379566, PMID 22343430, PMID 23219318, PMID 23698590, PMID 23955804, PMID 24036244, PMID 24361023, PMID 24622281, PMID 26388413, PMID 26971098, PMID 28101646, PMID 28305512, PMID 29578832, PMID 29724163, PMID 30110591, PMID 31443244, PMID 33849845, PMID 34688291, PMID 34849423, PMID 36215990, PMID 36335079, PMID 36876428, PMID 37114375, PMID 37115584, PMID 37408953, PMID 37989586, PMID 41704542, PMID 41989443, PMID 8367459, PMID 8374438, PMID 8426779, PMID 9468652
P20GM103644 (1), R01CA201429 (1), R01DA051001 (1), R34CA287720 (1), U01DA045519 (1)