591 completed. 591 Phase 2, 122 Phase 1, 12 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 591 | Completed 591 |
| Phase 1 | 122 | Completed 122 |
| Phase 3 | 12 | Completed 12 |
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Boron Neutron Capture Therapy (BNCT) Using B10 L-BPA in Recurrent Meningioma B10 L-BPA Injection - Meningioma, Boron Neutron Capture Therapy | Phase 1 / Phase 2 | Completed | Heron Neutron Medical Corp. | 10 | 2024-10-14 | 2026-05-11 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial Cognitive Behavioral Therapy for Insomnia - Primary Brain Tumor, Glioblastoma | Phase 2 | Completed | Virginia Commonwealth University | 70 | 2024-07-08 | 2025-10-01 |
| A Study of Rozanolixizumab in Pediatric Study Participants With Moderate to Severe Generalized Myasthenia Gravis rozanolixizumab - Generalized Myasthenia Gravis | Phase 2 / Phase 3 | Completed | UCB Biopharma SRL | 14 | 2024-06-14 | 2026-10-27 |
| High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis furmonertinib - Non-small Cell Lung Cancer Metastatic | Phase 2 | Completed | Sun Yat-sen University | 46 | 2024-01-01 | 2026-08-14 |
| HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease Patritumab deruxtecan - Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer | Phase 2 | Completed | MedSIR | 63 | 2023-11-24 | 2026-05-04 |
| Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases Serplulimab combined with bevacizumab and first-line chemotherapy - Non-small Cell Lung Cancer Stage II, Bevacizumab | Phase 2 / Phase 3 | Completed | Sun Yat-sen University | 40 | 2023-05-14 | 2024-11-13 |
| Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles Aumonertinib 165mg orally once daily and intrathecal chemotherapy with pemetrexed - Non-small Cell Lung Cancer | Phase 2 | Completed | Three Gorges Hospital of Chongqing University | 24 | 2023-01-01 | 2026-10-05 |
| Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases Best Practice, Neuropsychological Assessment, Quality-of-Life Assessment - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 110 | 2022-08-30 | 2026-10-21 |
| Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE) Furmonertinib 160 mg, Q.D. - Furmonertinib, EGFR-mutation | Phase 2 | Completed | Peking Union Medical College | 24 | 2022-07-11 | 2025-12-19 |
| Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation TY-9591 Tablets - NSCLC, EGFR Activating Mutation | Phase 2 | Completed | TYK Medicines, Inc | 29 | 2022-04-02 | 2024-12-30 |
| A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling avapritinib - Solid Tumor, Unspecified, Child, Relapsed Solid Neoplasm | Phase 1 / Phase 2 | Completed | Blueprint Medicines Corporation | 29 | 2022-02-24 | 2026-01-13 |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis Pemetrexed (1), Pemetrexed (2), Folic Acid - Leptomeningeal Metastases | Phase 1 / Phase 2 | Completed | The First Hospital of Jilin University | 34 | 2022-02-21 | 2025-05-04 |
| Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma TMZ, ipilimumab 3mg/kg, Nivolumab - Glioblastoma, Gliosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 47 | 2021-12-08 | 2026-04-17 |
| Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms. S-ketamine and pregabalin, Normal saline and placebo capsule - Esketamine, Pregabalin | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 90 | 2021-12-01 | 2023-07-06 |
| OH2 Oncolytic Viral Therapy in Central Nervous System Tumors OH2 injection - Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | Binhui Biopharmaceutical Co., Ltd. | 40 | 2021-11-16 | 2026-08-05 |
| Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Fluorescein Sodium, YELLOW560 filter - Vestibular Schwannoma | Phase 2 | Completed | Mayo Clinic | 12 | 2021-10-06 | 2023-08-01 |
| Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System tozuleristide, Canvas imaging system, Surgical resection of tumor - Central Nervous System Tumor | Phase 2 | Completed | John Yu | 50 | 2021-09-30 | 2026-07-10 |
| Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma Dendritic cell vaccination + temozolomide-based chemoradiation, Dendritic cell vaccination +- conventional next-line treatment - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Completed | University Hospital, Antwerp | 10 | 2021-09-10 | 2026-06-05 |
| Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis IA session, Rituximab - Anti-NMDAR Encephalitis | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 20 | 2021-06-23 | 2026-08-10 |
Showing 20 of 591. Sign in to see all of them.
Brain Neoplasms (373) · Glioblastoma (229) · Central Nervous System Neoplasms (202) · Gliosarcoma (158) · Glioma (133) · Astrocytoma (125) · Oligodendroglioma (93) · Sarcoma (42) · Medulloblastoma (40) · Ependymoma (37) · Breast Neoplasms (32) · Meningioma (32) · Neoplasm Metastasis (30) · Carcinoma, Non-Small-Cell Lung (29) · Neuroblastoma (28)
Nervous System Diseases (586) · Neoplasms (566) · Neoplasms by Site (559) · Neoplasms by Histologic Type (438) · Neoplasms, Nerve Tissue (416) · Central Nervous System Diseases (403) · Brain Diseases (395) · Neoplasms, Germ Cell and Embryonal (376) · Neuroectodermal Tumors (372) · Neoplasms, Glandular and Epithelial (356) · Neoplasms, Neuroepithelial (342) · Central Nervous System Neoplasms (313) · Glioma (195) · Astrocytoma (143)
Temozolomide (92) · Radiotherapy (70) · Bevacizumab (58) · Irinotecan (27) · Carboplatin (25) · Filgrastim (23) · Cyclophosphamide (21) · Etoposide (21) · Cisplatin (19) · Carmustine (16) · Vincristine (16) · Chemotherapy, Adjuvant (15) · Erlotinib Hydrochloride (15) · Peripheral Blood Stem Cell Transplantation (14) · Everolimus (13)
National Cancer Institute (NCI) (77) · Duke University (33) · Memorial Sloan Kettering Cancer Center (24) · M.D. Anderson Cancer Center (17) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (17) · European Organisation for Research and Treatment of Cancer - EORTC (16) · Radiation Therapy Oncology Group (14) · Children's Oncology Group (12) · Novartis Pharmaceuticals (12) · Alliance for Clinical Trials in Oncology (10) · Dana-Farber Cancer Institute (9) · New Approaches to Brain Tumor Therapy Consortium (9) · Assistance Publique - Hôpitaux de Paris (8) · Jonsson Comprehensive Cancer Center (6) · NYU Langone Health (6)
United States (449) · Canada (76) · France (52) · Germany (32) · Italy (30) · Australia (29) · Netherlands (29) · Belgium (28) · Spain (28) · Switzerland (27) · United Kingdom (26) · China (25) · Puerto Rico (17) · Austria (12) · Denmark (11)
Henry S. Friedman, MD (10) · David A. Reardon, MD (6) · Edward G. Shaw, MD (5) · Jan C. Buckner, MD (5) · Darell D. Bigner, MD, PhD (4) · Evanthia Galanis (4) · Lauren E. Abrey, MD (4) · Patrick Y. Wen, MD (4) · Susan M. Chang, MD (4) · Thomas Kaley, MD (4) · Annick Desjardins, MD, FRCPC (3) · Betty Lawrence (3) · David M. Peereboom, MD (3)
PMID 31401903, PMID 25098701, PMID 27243238, PMID 34331515, PMID 35350948, PMID 36884302, PMID 10501910, PMID 11705489, PMID 11772431, PMID 11835236, PMID 11907388, PMID 12525516, PMID 12528778, PMID 12649108, PMID 12829671, PMID 12957454, PMID 1408229, PMID 14586216, PMID 14625709, PMID 14670747, PMID 14769135, PMID 14769136, PMID 14769138, PMID 14769140, PMID 15010069, PMID 15073861, PMID 15117425, PMID 15177491, PMID 15292713, PMID 15514370, PMID 15565574, PMID 15592836, PMID 15659504, PMID 15667956, PMID 15758009, PMID 16012795, PMID 16034522, PMID 16053699, PMID 16133802, PMID 16170172, PMID 16200343, PMID 16314647, PMID 16391300, PMID 16408203, PMID 16443947, PMID 16528479, PMID 16532433, PMID 16533878, PMID 16549835, PMID 16750317
U10CA098543 (11), U10CA180886 (11), P30CA008748 (8), U01CA062399 (8), U01CA062475 (8), U10CA025224 (8), 2014 (7), P30CA006516 (6), U10CA021661 (5), 2016 (4), P30CA043703 (4), U01CA137443 (4), 2009 (3), 2015 (3), 2017 (3)