39 completed, 29 recruiting, 15 terminated, 13 active not recruiting. 71 Phase 1, 44 Phase 2, 7 Early Phase 1, 6 Not applicable, 4 Phase 3.
Follow Diffuse Intrinsic Pontine Glioma: new trials by email Literature Review of Diffuse Intrinsic Pontine Glioma trials Research Report on Diffuse Intrinsic Pontine Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-27 |
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-08-26 |
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2026-11-01 | 2026-09-09 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-09-30 | 2026-09-11 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-21 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor Gallium maltolate - High Grade Gliomas, Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 1 | Not yet recruiting | Sarah Rumler | 15 | 2026-05-15 | 2026-01-09 |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma VRT106 for injection - Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Intrinsic Pontine Glioma | Phase 2 | Recruiting | Guangzhou Virotech Pharmaceutical Co., Ltd. | 10 | 2026-05-07 | 2026-05-15 |
| Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation M032 - Glioma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 20 | 2026-04-23 | 2026-10-09 |
| Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2 - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Early Phase 1 | Recruiting | Nationwide Children's Hospital | 15 | 2025-08-03 | 2026-06-29 |
| ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas ACT001 - Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG | Phase 2 | Recruiting | Nationwide Children's Hospital | 60 | 2025-07-10 | 2026-09-21 |
| Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age SIACI of cetuximab and bevacizumab - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 1 / Phase 2 | Recruiting | University of Miami | 20 | 2025-06-19 | 2025-12-08 |
| Atovaquone Combined With Radiation in Children With Malignant Brain Tumors Atovaquone, Radiation Therapy - High-grade Glioma, Medulloblastoma | Phase 1 | Recruiting | Emory University | 18 | 2025-03-28 | 2026-08-03 |
| A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer Cobolimab, Dostarlimab - Melanoma, Hodgkin Lymphoma | Phase 1 / Phase 2 | Active not recruiting | GlaxoSmithKline | 83 | 2025-03-06 | 2025-11-12 |
| Study of Olutasidenib and Temozolomide in HGG Olutasidenib + TMZ - High Grade Glioma, Astrocytoma | Phase 2 | Recruiting | Rigel Pharmaceuticals | 60 | 2025-02-01 | 2026-09-01 |
Showing 20 of 118. Sign in to see all of them.
Glioma (57) · Brain Neoplasms (32) · Glioblastoma (27) · Astrocytoma (22) · Medulloblastoma (21) · Ependymoma (12) · Rhabdoid Tumor (11) · Recurrence (10) · Central Nervous System Neoplasms (9) · Neuroblastoma (7) · Gliosarcoma (6) · Neoplasms (6) · Neuroectodermal Tumors, Primitive (6) · Oligodendroglioma (6)
Central Nervous System Diseases (118) · Infratentorial Neoplasms (118) · Neoplasms by Histologic Type (118) · Neoplasms by Site (118) · Neoplasms, Glandular and Epithelial (118) · Neoplasms, Nerve Tissue (118) · Nervous System Diseases (118) · Neuroectodermal Tumors (118) · Brain Diseases (117) · Nervous System Neoplasms (117) · Brain Stem Neoplasms (116) · Neoplasms, Germ Cell and Embryonal (114) · Neoplasms, Neuroepithelial (114) · Neoplasms (112) · Central Nervous System Neoplasms (109)
Temozolomide (15) · Radiotherapy (11) · Bevacizumab (6) · Everolimus (6) · Cyclophosphamide (5) · Irinotecan (5) · Panobinostat (4) · Radiation (4) · ribociclib (4) · Dasatinib (3) · Etoposide (3) · Nivolumab (3) · Re-Irradiation (3) · Specimen Handling (3) · TIC10 compound (3)
Nationwide Children's Hospital (10) · National Cancer Institute (NCI) (8) · Children's Hospital Medical Center, Cincinnati (4) · Sabine Mueller, MD, PhD (4) · St. Jude Children's Research Hospital (4) · Children's Oncology Group (3) · M.D. Anderson Cancer Center (3) · University of Florida (3) · Baylor College of Medicine (2) · Capital Medical University (2) · Children's National Research Institute (2) · Columbia University (2) · Emory University (2) · Gustave Roussy, Cancer Campus, Grand Paris (2) · Pediatric Brain Tumor Consortium (2)
United States (88) · Canada (15) · Australia (12) · Germany (10) · China (9) · New Zealand (7) · Spain (6) · France (5) · Italy (5) · Netherlands (4) · United Kingdom (4) · Belgium (3) · Switzerland (3) · Czechia (2) · Denmark (2)
Maryam Fouladi, MD (8) · Margot Lazow, MD (4) · Alberto Broniscer, MD (2) · Hongwei Zhang, Prof. (2) · John W Glod, M.D. (2) · Rebecca Ronsley, MD (2) · Sabine Mueller, MD, PhD (2) · Sabine Mueller, MD, PhD, MAS (2) · Susan Chi, MD (2) · Adam Green, MD (1) · Allen Mellemed, MD (1) · Amar Gajjar, MD (1) · Anna Vinitsky, MD (1) · Ashley Plant-Fox, MD (1)
PMID 10655437, PMID 11937316, PMID 12177103, PMID 12434281, PMID 14506149, PMID 16011702, PMID 16078267, PMID 16265674, PMID 16510333, PMID 16598416, PMID 16645718, PMID 17544337, PMID 17647306, PMID 17909941, PMID 18217208, PMID 18577561, PMID 18990510, PMID 19147777, PMID 19223865, PMID 19957326, PMID 19985059, PMID 20694800, PMID 20708924, PMID 20921456, PMID 20974795, PMID 21087935, PMID 21171927, PMID 21292687, PMID 21297126, PMID 21297433, PMID 21327862, PMID 22132908, PMID 22331797, PMID 22492959, PMID 22747087, PMID 22747092, PMID 23043252, PMID 23092726, PMID 23536435, PMID 23813229, PMID 24076776, PMID 24297113, PMID 24327518, PMID 24560760, PMID 24626721, PMID 24696052, PMID 24705254, PMID 24847085, PMID 24894482, PMID 24903904
UM1CA081457 (5), 2009 (2), 2014 (2), 2015 (2), 2023 (2), UM1CA097452 (2), 2019 (1), 5UM1CA081457 (1), P30CA015083 (1), P30CA016672 (1), R01CA187202 (1), R01CA229646 (1), R01CA296813 (1), R01NS124607 (1), R44CA261516 (1)