7 completed, 6 unknown, 2 not yet recruiting, 2 terminated. 7 Not applicable, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 2, Not yet recruiting 2, Active not recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Withdrawn 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Multi Organ Failure: new trials by email Literature Review of Multi Organ Failure trials Research Report on Multi Organ Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study) Oxiris Filter (Blood Purification Device) - Septic Shock, Multi Organ Failure | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 62 | 2026-02-01 | 2026-01-14 |
| Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure RELiZORB™, Placebo - Multi Organ Failure, Exocrine Pancreatic Insufficiency | Not applicable | Active not recruiting | Inova Health Care Services | 32 | 2025-05-07 | 2026-10-13 |
| Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock Sepsis, Septic Shock | Enrolling by invitation | Ankara City Hospital Bilkent | 250 | 2025-05-01 | 2025-07-28 | |
| OXiris for Abdominal SEptic Shock (OASES Study) CRRT filter - Septic Shock, Abdominal Sepsis | Not applicable | Not yet recruiting | RenJi Hospital | 192 | 2024-08-15 | 2024-07-16 |
| High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill Optiflow Switch - Critical Illness, Respiratory Failure | Recruiting | Region Stockholm | 150 | 2023-09-25 | 2025-04-11 | |
| Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction Hemodialysis, ADVOS - Liver Cirrhosis, Kidney Failure, Acute | Not applicable | Unknown | University Medical Center Mainz | 14 | 2023-06-01 | 2023-11-13 |
| Acute Cardiac Dysfunction in Critical Illnes Echocardiography, Cardiac magnetic resonance imaging, Coronary CT - Multi Organ Failure, Left Ventricular Dysfunction | Unknown | Sahlgrenska University Hospital | 592 | 2023-05-29 | 2023-10-06 | |
| Doppler Ultrasound Renal Arterial Resistive Indices As Predictor Of Multiorgan Failure In Patients With Acute Hypoxic Respiratory Failure Admitted To Respiratory Intensive Care Unit (Cryptic Shock Index- RICU) Doppler ultrasound assessment of renal arteria resistive index - Respiratory Failure, Multi Organ Failure | Unknown | University of Modena and Reggio Emilia | 30 | 2023-01-01 | 2022-03-23 | |
| European Registry for Hemadsorption in Sepsis With the Seraph Filter Hemoperfusion - Sepsis, Acute Respiratory Distress Syndrome | Unknown | Croatian Society for Organ Support | 300 | 2022-10-25 | 2022-11-08 | |
| Registry for Hemoperfusion of Covid-19 ICU Patients Hemoperfusion - COVID-19 Acute Respiratory Distress Syndrome, Viral Disease | Completed | Croatian Society for Organ Support | 1050 | 2022-07-21 | 2025-02-13 | |
| Long Term Renal Function After CRRT in the Paediatric Intensive Care Unit, a Follow-up Study. Acute Kidney Injury, Multi Organ Failure | Completed | Region Stockholm | 156 | 2022-01-20 | 2025-07-31 | |
| The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock HA330 hemoadsorption technique - Septic Shock, Multi Organ Failure | Not applicable | Completed | Chulalongkorn University | 10 | 2021-07-01 | 2022-06-02 |
| Early Renal Replacement Therapy in COVID 19 Patients With AKI Does it Improve the Outcome? haemodialysis - Multi Organ Failure | Not applicable | Completed | Sohag University | 100 | 2021-06-01 | 2022-03-10 |
| Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients Blood Draw - Inflammatory Response, Multi Organ Failure | Unknown | Joseph M. Still Research Foundation, Inc. | 65 | 2019-10-02 | 2021-08-25 | |
| Postoperative Respiratory Abnormalities Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data - Respiratory Failure, Respiratory Arrest | Unknown | Efficacy Care R&D Ltd | 50000 | 2019-09-01 | 2020-06-24 | |
| Infusion of Prostacyclin vs Placebo for 72-hours in Trauma Patients With Haemorrhagic Shock Suffering From Organ Failure Iloprost, Isotonic saline - Multi Organ Failure | Phase 2 | Completed | Pär Johansson | 228 | 2019-05-22 | 2024-05-08 |
| Parathyroid Hormone Kinetics During CRRT parathyroid hormone - Critical Illness, Multi Organ Failure | Completed | Uniwersytecki Szpital Kliniczny w Opolu | 30 | 2019-05-06 | 2022-01-14 | |
| Vitamin D Status in Patients With Severe Sepsis vitamin D3, Placebo - Sepsis, Severe Sepsis | Phase 3 | Withdrawn | Massachusetts General Hospital | 2017-12-01 | 2021-05-05 | |
| Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA Interferon Beta-1A, Placebo - Preventive Medicine, Multi Organ Failure | Phase 2 | Terminated | Faron Pharmaceuticals Ltd | 40 | 2017-02-18 | 2021-01-14 |
| Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT biospecimen retention - Multi Organ Failure, Acute Kidney Injury | Completed | Uniwersytecki Szpital Kliniczny w Opolu | 40 | 2015-08-01 | 2022-01-14 |
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Multiple Organ Failure (22) · Acute Kidney Injury (8) · Critical Illness (5) · Shock, Septic (5) · Respiratory Insufficiency (4) · Sepsis (3) · Renal Insufficiency (2) · Respiratory Distress Syndrome (2) · Shock (2) · Systemic Inflammatory Response Syndrome (2) · Apnea (1) · Cross Infection (1) · Cytomegalovirus Infections (1) · Disease (1) · Exocrine Pancreatic Insufficiency (1)
Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Shock (20) · Infections (10) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Kidney Diseases (9) · Male Urogenital Diseases (9) · Urogenital Diseases (9) · Urologic Diseases (9) · Inflammation (8) · Renal Insufficiency (7) · Disease Attributes (6) · Systemic Inflammatory Response Syndrome (6) · Respiration Disorders (5)
Hemoperfusion (2) · Blood Specimen Collection (1) · Cholecalciferol (1) · Dialysis (1) · Drugs, Investigational (1) · Echocardiography (1) · Ganciclovir (1) · Iloprost (1) · Interferon beta-1a (1) · Methods (1) · Renal Dialysis (1) · Sodium Chloride (1)
Croatian Society for Organ Support (2) · Region Stockholm (2) · Uniwersytecki Szpital Kliniczny w Opolu (2) · Ankara City Hospital Bilkent (1) · Chulalongkorn University (1) · Efficacy Care R&D Ltd (1) · Faron Pharmaceuticals Ltd (1) · Inova Health Care Services (1) · Joseph M. Still Research Foundation, Inc. (1) · Massachusetts General Hospital (1) · Pusan National University Yangsan Hospital (1) · Pär Johansson (1) · RenJi Hospital (1) · Sahlgrenska University Hospital (1) · Sohag University (1)
United States (4) · Sweden (3) · Croatia (2) · Norway (2) · Poland (2) · Belgium (1) · China (1) · Denmark (1) · Egypt (1) · Estonia (1) · Finland (1) · Germany (1) · Lithuania (1) · Thailand (1) · Turkey (Türkiye) (1)
Anders Hartmann, MD, Ph.D. (1) · George Kasotakis, MD MPH (1) · Harri Hakovirta, MD (1) · Jan F Bugge, MD, Ph.D. (1) · Julia Weinmann-Menke, Prof. (1) · Maarit Venermo, MD (1) · Michael Quinn, MD (1) · Nadav Lankin (1) · Paul G Loubser, MD (1) · Raymond Vanholder, MD, PhD (1) · Sadeq A Quraishi, MD (1) · Tomasz Czarnik, MD PhD (1)
PMID 16374442, PMID 17464154, PMID 19327959, PMID 20042260, PMID 22206744, PMID 25683273, PMID 29199512, PMID 29385364, PMID 29396136, PMID 31157412, PMID 33242935, PMID 33393084, PMID 34010434, PMID 35115574, PMID 40633959, PMID 41179859
2014 (1), 2019 (1), 2023 (1)