7 completed, 7 recruiting, 3 active not recruiting, 2 terminated. 10 Phase 2, 8 Phase 1, 4 Not applicable, 3 Phase 3, 1 Early Phase 1.
Follow Metastatic Malignant Neoplasm in the Lung: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Lung trials Research Report on Metastatic Malignant Neoplasm in the Lung
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using an Artificial Intelligence Software Tool (iSeg) During Radiation Treatment Planning for Patients With Lung Tumors Artificial Intelligence-based Intervention, Best Practice, Computed Tomography - Lung Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Not yet recruiting | Northwestern University | 34 | 2027-02-13 | 2026-10-27 |
| Aerosolized Sargramostim Added to Immunotherapy for the Treatment of Patients With Metastatic Melanoma to the Lung Aerosol Sargramostim, Biospecimen Collection, Computed Tomography - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Lung | Phase 1 | Withdrawn | Mayo Clinic | 2025-10-28 | 2025-08-07 | |
| Molecular Analysis of Suspected or High-Risk Lung Cancer to Drive Individualized Care Non-Interventional Study - Lung Carcinoma, Metastatic Malignant Neoplasm in the Lung | Recruiting | Mayo Clinic | 250 | 2024-06-24 | 2026-09-08 | |
| Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Lung Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Recruiting | Northwestern University | 70 | 2023-11-20 | 2026-05-29 |
| Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies Hafnium Oxide-containing Nanoparticles NBTXR3, Radiation Therapy - Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 40 | 2023-05-08 | 2026-07-30 |
| Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma Biospecimen Collection, Computed Tomography, Questionnaire Administration - Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 62 | 2022-04-01 | 2026-08-25 |
| Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING Study Computed Tomography, Indocyanine Green Solution, Therapeutic Bronchoscopy - Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2022-01-26 | 2024-10-23 | |
| Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases Cisplatin, Isolated Chemotherapeutic Lung Perfusion, Metastasectomy - Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 99 | 2020-07-16 | 2026-08-21 |
| Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers Nivolumab, Ipilimumab, Stereotactic Body Radiation Therapy - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Completed | University of Washington | 20 | 2019-01-15 | 2023-12-29 |
| Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery Near-Infrared Fluorescence Imaging, Panitumumab-IRDye800, Pharmacokinetic Study - Lung Carcinoma, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Recruiting | Stanford University | 30 | 2018-07-19 | 2026-10-05 |
| Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer Biphasic Positive Airway Pressure, Computed Tomography, Continuous Positive Airway Pressure - Lung Carcinoma, Malignant Respiratory Tract Neoplasm | Not applicable | Recruiting | M.D. Anderson Cancer Center | 30 | 2018-03-16 | 2026-08-11 |
| First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide 18F-αvβ6-BP - Breast Carcinoma, Colorectal Carcinoma | Early Phase 1 | Active not recruiting | Julie L. Sutcliffe, Ph.D | 27 | 2016-11-01 | 2026-02-27 |
| Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery Chemotherapy, Laboratory Biomarker Analysis, Metastasectomy - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Terminated | M.D. Anderson Cancer Center | 29 | 2016-09-23 | 2026-02-17 |
| Dinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma Dinutuximab, Laboratory Biomarker Analysis, Pharmacological Study - Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 41 | 2016-02-04 | 2023-10-26 |
| CT Perfusion Imaging in Predicting Treatment Response in Patients With Non-small Cell Lung Cancer or Lung Metastases Treated With Stereotactic Ablative Radiation Therapy CAPP-Seq, Isovue-200, Computed Tomography Perfusion Imaging - Malignant Lung Neoplasm, Metastatic Malignant Neoplasm in the Lung | Phase 1 | Completed | Stanford University | 19 | 2016-01-19 | 2023-11-22 |
| Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival Stereotactic Body Radiotherapy, Surgery - Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma | Phase 2 / Phase 3 | Completed | NRG Oncology | 129 | 2014-12-24 | 2026-07-10 |
| Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Cyclophosphamide, Doxorubicin, Doxorubicin Hydrochloride - Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 312 | 2014-12-12 | 2026-10-22 |
| Proton Beam Re-Irradiation in Thoracic Cancers Proton Beam Radiation Therapy - Metastatic Malignant Neoplasm in the Lung, Recurrent Disease | Not applicable | Completed | University of Washington | 6 | 2014-09-09 | 2018-11-20 |
| Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy Doxepin Hydrochloride, Placebo, Quality-of-Life Assessment - Esophageal Carcinoma, Hypopharyngeal Carcinoma | Phase 2 | Terminated | Mayo Clinic | 5 | 2014-04-14 | 2019-10-01 |
| Aerosolized Aldesleukin in Treating Patients With Lung Metastases Aerosolized Aldesleukin, Laboratory Biomarker Analysis - Metastatic Malignant Neoplasm in the Lung, Metastatic Melanoma | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 70 | 2012-06-28 | 2026-10-15 |
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Lung Neoplasms (9) · Carcinoma, Non-Small-Cell Lung (6) · Colorectal Neoplasms (4) · Sarcoma (4) · Osteosarcoma (3) · Breast Neoplasms (2) · Melanoma (2) · Bone Neoplasms (1) · Carcinoma, Renal Cell (1) · Esophageal Neoplasms (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1) · Lymphatic Metastasis (1) · Lymphoma (1) · Mesothelioma (1)
Neoplasms (22) · Neoplasms by Site (18) · Lung Diseases (11) · Respiratory Tract Diseases (11) · Respiratory Tract Neoplasms (11) · Thoracic Neoplasms (11) · Neoplasms by Histologic Type (8) · Neoplasms, Connective and Soft Tissue (7) · Bronchial Neoplasms (6) · Carcinoma, Bronchogenic (6) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Gastrointestinal Neoplasms (5) · Colonic Diseases (4)
Radiosurgery (6) · Magnetic Resonance Spectroscopy (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Cisplatin (2) · Metastasectomy (2) · Nivolumab (2) · Platinum (2) · Radiation (2) · Specimen Handling (2) · X-Rays (2) · CTLA-4 Antigen (1) · Colony-Stimulating Factors (1) · Congresses as Topic (1) · Continuous Positive Airway Pressure (1) · Cyclophosphamide (1)
M.D. Anderson Cancer Center (6) · Mayo Clinic (3) · National Cancer Institute (NCI) (2) · Northwestern University (2) · Roswell Park Cancer Institute (2) · Stanford University (2) · University of Washington (2) · Children's Oncology Group (1) · Julie L. Sutcliffe, Ph.D (1) · NRG Oncology (1)
United States (22) · Canada (4) · Puerto Rico (3) · Australia (2) · New Zealand (2) · Saudi Arabia (2) · South Korea (1)
Chukwumere Nwogu (1) · Cristina Rodriguez (1) · David W Rice (1) · Janani S. Reisenauer, M.D. (1) · Jing Zeng (1) · John J Doski (1) · Julianne M Pollard (1) · Julie Sutcliffe (1) · Kenneth Seastedt (1) · Maximilian Diehn (1) · Mohamed E Abazeed (1) · Mohamed E Abazeed, MD, PhD (1) · Najat Daw (1) · Natalie Lui (1) · Osama Mawlawi (1)
PMID 35602670, PMID 36669140, PMID 42208702
U10CA180886 (3), P30CA060553 (2), P30CA015083 (1), P30CA015704 (1), P30CA016672 (1), P30CA093373 (1), U10CA098543 (1), U10CA180868 (1)