4 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 4 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 2, Completed 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Massive Hemorrhage: new trials by email Literature Review of Massive Hemorrhage trials Research Report on Massive Hemorrhage
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Point of Care Fibrinogen Measurement in Trauma Patients in the Emergency Department Trauma Induced Coagulopathy, Trauma Coagulopathy | Recruiting | Erasmus Medical Center | 50 | 2025-11-01 | 2026-10-06 | |
| Calcium Administration in Life-saving Management During Massive Hemorrhage calcium gluconate, Control: Placebo - Massive Hemorrhage, Trauma | Phase 2 / Phase 3 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 81 | 2025-05-01 | 2025-02-11 |
| Study to Actively Warm Trauma Patients-2 Ready-Heat Chemical Heating Blankets, Warmed blankets or FAWB - Trauma Injury, Hypothermia | Not applicable | Unknown | Sunnybrook Health Sciences Centre | 74 | 2024-03-01 | 2024-03-20 |
| Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance Albumin solution, Balanced crystalloid solution - Bleeding, Massive Hemorrhage | Not applicable | Unknown | Seoul National University Hospital | 36 | 2023-11-15 | 2023-11-01 |
| Factor In the Initial Resuscitation of Severe Trauma 2 Patients Fibrinogen + PCC, Frozen Plasma - Traumatic Hemorrhage, Coagulopathy | Phase 4 | Terminated | University Health Network, Toronto | 142 | 2021-04-01 | 2026-10-21 |
| Prediction of Massive Transfusion in Trauma Patients Comparison of score performances (Overall performance, discrimination and calibration) - Trauma Injury, Haemorrhagic Shock | Completed | Centre Hospitalier Universitaire Vaudois | 13222 | 2020-08-01 | 2022-03-08 | |
| Use of Viscoelastic Tests in the Treatment of Traumatic Induced Coagulopathy: a Pragmatic Randomized Clinical Trial. Trauma-induced coagulopathy treatment - Trauma, Multiple, Coagulopathy | Not applicable | Withdrawn | A.O. Ospedale Papa Giovanni XXIII | 2019-12-01 | 2021-03-03 | |
| Patient Blood Management for Massive Obstetric Hemorrhage Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human - Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage | Not applicable | Completed | Angel Augusto Perez Calatayud | 100 | 2018-11-01 | 2021-06-08 |
| Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains Malaysia NovoSeven - Massive Hemorrhage, Massive Blood Loss | Completed | Universiti Sains Malaysia | 76 | 2017-08-21 | 2018-10-10 | |
| Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC) Human Fibrinogen Concentrate, Placebo - Trauma, Massive Hemorrhage | Phase 1 / Phase 2 | Completed | Medical University Innsbruck | 67 | 2011-09-01 | 2015-12-08 |
Wounds and Injuries (4) · Accidental Injuries (2) · Hemorrhage (2) · Hemostatic Disorders (2) · Afibrinogenemia (1) · Disseminated Intravascular Coagulation (1) · Emergencies (1) · Hemophilia B (1) · Hypocalcemia (1) · Hypothermia (1) · Multiple Trauma (1) · Postpartum Hemorrhage (1) · Shock, Hemorrhagic (1) · Thrombocytopenia (1)
Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Hemorrhagic Disorders (4) · Pathological Conditions, Signs and Symptoms (4) · Blood Coagulation Disorders (3) · Pathologic Processes (3) · Blood Coagulation Disorders, Inherited (2) · Cardiovascular Diseases (2) · Coagulation Protein Disorders (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Vascular Diseases (2) · Wounds and Injuries (2) · Blood Platelet Disorders (1) · Body Temperature Changes (1)
Fibrinogen (3) · prothrombin complex concentrates (2) · Blood Coagulation Tests (1) · Calcium (1) · Calcium Gluconate (1) · Calibration (1) · Erythrocyte Count (1) · Platelet Count (1) · Sodium Chloride (1) · Thrombelastography (1) · recombinant FVIIa (1)
A.O. Ospedale Papa Giovanni XXIII (1) · Angel Augusto Perez Calatayud (1) · Centre Hospitalier Universitaire Vaudois (1) · Erasmus Medical Center (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Medical University Innsbruck (1) · Seoul National University Hospital (1) · Sunnybrook Health Sciences Centre (1) · Universiti Sains Malaysia (1) · University Health Network, Toronto (1)
Austria (1) · Canada (1) · Czechia (1) · Germany (1) · Italy (1) · Malaysia (1) · Mexico (1) · Netherlands (1) · Switzerland (1)
Angel Augusto Perez Calatayud, M.D. (1) · Caroline van der Marel, MD, PhD (1) · Chong Soon Eu, MD, MMed (1) · Dietmar Fries, Prof. MD (1) · Luis Da Luz, MD (1) · Luis T Da Luz, MD (1) · Niki A. Ottenhof, MD, PhD (1) · Nurfatin Mohd Shah, BSc (1) · Pierre-Nicolas Carron, MD (1) · Seung-young Oh, M.D. (1)
PMID 26591047, PMID 33109923, PMID 34479938, PMID 36171598, PMID 40982282