621 completed, 117 unknown, 107 recruiting, 79 terminated. 228 Phase 3, 141 Not applicable, 136 Phase 1, 122 Phase 2, 83 Phase 4.
Follow Coagulation Protein Disorders: new trials by email Literature Review of Coagulation Protein Disorders trials Research Report on Coagulation Protein Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lentiviral FIX Gene Therapy YUVA-GT-F901 - Hemophilia B | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2027-06-01 | 2026-08-26 |
| Lentiviral FVIII Gene Therapy YUVA-GT-F801 - Hemophilia A | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2027-06-01 | 2026-09-01 |
| Post Approval Phase 4 Study to Learn More About How Safe Octocog Alfa is, and How Well it Works in Patients With Severe Hemophilia A in India Octocog alfa - Severe Hemophilia A | Not yet recruiting | Bayer | 30 | 2027-04-05 | 2026-10-21 | |
| Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy Multicomponent pain self-management programme - Hemophilic Arthropathy, Chronic Pain | Not applicable | Not yet recruiting | Investigación en Hemofilia y Fisioterapia | 70 | 2027-03-01 | 2026-10-06 |
| Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%) Joint Ultrasound (HEAD-US), Blood Sample for Coagulation Factor Measurement - Mild Hemophilia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 150 | 2027-02-01 | 2026-08-17 |
| Efanesoctocog Prophylaxis Or The Optimization Of Treatment: Real-World Experience Of Taylorizing Clotting Therapy In Hemophilia A Study questionnaires, Clinical/pharmacological data collection - Hemophilia A Patient | Not yet recruiting | Nantes University Hospital | 553 | 2027-01-01 | 2026-09-25 | |
| Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A FRSW107 - Severe Hemophilia A | Phase 3 | Not yet recruiting | Hangzhou Gensciences Biopharmaceutical Co., Ltd. | 76 | 2026-12-25 | 2024-06-20 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Clinical Trial of NXT007 for the Prophylactic Treatment of Hemophilia A in Infants and Children NXT007 - Hemophilia A | Phase 3 | Not yet recruiting | Hoffmann-La Roche | 50 | 2026-11-30 | 2026-10-19 |
| Liver Biopsy Following Gene Therapy For Hemophilia Liver Biopsy - Hemophilia A, Hemophilia B | Not yet recruiting | St. Jude Children's Research Hospital | 8 | 2026-11-01 | 2026-10-22 | |
| A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A Denecimig - Haemophilia A | Phase 3 | Not yet recruiting | Novo Nordisk A/S | 84 | 2026-10-09 | 2026-09-21 |
| A Study to Learn About the Study Medicine (Called Marstacimab) in People With Hemophilia A or B Marstacimab - Hemophilia | Not yet recruiting | Pfizer | 100 | 2026-10-05 | 2026-10-05 | |
| Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE) Aripiprazole (low-dose, 1mg), Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Christiana Franke | 138 | 2026-10-01 | 2026-07-20 |
| A Study of Elranatamab for Inhibitor Eradication in Patients With Hemophilia A Elranatamab - Hemophilia A With Inhibitors | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 20 | 2026-10-01 | 2026-08-26 |
| A Phase 2 Study of Foscenvivint in Liver Cirrhosis Patients Caused by HIV/HCV Co-infection With Hemophilia Foscenvivint - Liver Cirrhosis | Phase 2 | Recruiting | Kiminori Kimura, MD | 7 | 2026-10-01 | 2026-10-05 |
| A Phase III Clinical Trial Evaluating SR604 Injection for Prophylactic Treatment in Patients With Hemophilia SR604 - Hemophilia A, Hemophilia A and B | Phase 3 | Not yet recruiting | Shanghai RAAS Blood Products Co., Ltd. | 90 | 2026-09-30 | 2026-10-15 |
| Study of a Smart Sharps Disposal Device in Patients With Hemophilia The smart Sharps device is given to the patient and they use it to throw needles away in. It is not internal to the patient. - Hemophilia A and B | Not applicable | Not yet recruiting | University of Pennsylvania | 23 | 2026-09-30 | 2026-07-09 |
| Patient Preferences in Treatment of Haemophilia A With and Without Inhibitors: a Discrete Choice Experiment in Germany No treatment given - Haemophilia A | Enrolling by invitation | Novo Nordisk A/S | 150 | 2026-09-25 | 2026-10-06 | |
| A Prospective Assessment of Bone Health in Patients With Severe Hemophilia A on Factor VIII vs Factor Mimetic Prophylaxis (Efa Emi Bone Health Study) Hemophilia a | Recruiting | Arkansas Children's Hospital Research Institute | 50 | 2026-09-21 | 2026-10-05 | |
| Cryo-FIRST: Effectiveness of INTERCEPT Fibrinogen Complex (IFC) for Trauma-Associated Hemorrhage Pathogen Reduced Cryoprecipitated Fibrinogen Complex - Hypofibrinogenemia, Hemorrhage | Enrolling by invitation | Cerus Corporation | 320 | 2026-09-15 | 2026-10-14 |
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Hemophilia A (787) · Hemophilia B (260) · von Willebrand Diseases (95) · Blood Coagulation Disorders (42) · Hemostatic Disorders (42) · Hematologic Diseases (40) · Hemorrhage (31) · Joint Diseases (30) · Afibrinogenemia (25) · Hemorrhagic Disorders (25) · Genetic Diseases, Inborn (22) · Blood Coagulation Disorders, Inherited (18) · Motor Activity (18) · Thrombosis (15)
Hemic and Lymphatic Diseases (1048) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1046) · Blood Coagulation Disorders, Inherited (1028) · Genetic Diseases, Inborn (1024) · Hemorrhagic Disorders (1020) · Hematologic Diseases (1008) · Blood Coagulation Disorders (1006) · Genetic Diseases, X-Linked (257) · Pathological Conditions, Signs and Symptoms (123) · Blood Platelet Disorders (98) · Pathologic Processes (90) · Musculoskeletal Diseases (73) · Cardiovascular Diseases (69) · Vascular Diseases (63)
Factor VIII (136) · F8 protein, human (56) · Factor IX (34) · emicizumab (34) · BAY 14-2222 (22) · von Willebrand Factor (20) · factor VIII-Fc fusion protein (19) · recombinant factor VIII N8 (19) · BAX 855 (18) · Injections (16) · Blood Specimen Collection (15) · recombinant factor VIII SQ (14) · recombinant FVIIa (13) · BIVV001 (11) · Fibrinogen (11)
Novo Nordisk A/S (80) · Bayer (57) · Baxalta now part of Shire (56) · Pfizer (44) · CSL Behring (41) · Octapharma (23) · Wyeth is now a wholly owned subsidiary of Pfizer (21) · Investigación en Hemofilia y Fisioterapia (20) · Hoffmann-La Roche (19) · Bio Products Laboratory (16) · Swedish Orphan Biovitrum (16) · Institute of Hematology & Blood Diseases Hospital, China (15) · Takeda (15) · Hospices Civils de Lyon (13) · Bioverativ Therapeutics Inc. (11)
United States (374) · Spain (203) · United Kingdom (202) · France (194) · Germany (186) · Italy (183) · Canada (128) · China (109) · Turkey (Türkiye) (109) · Japan (96) · Poland (94) · Netherlands (91) · Austria (86) · Australia (78) · Sweden (76)
Lei Zhang, MD (11) · Renchi Yang, PhD (6)
PMID 40750723, PMID 26196195, PMID 40386832, PMID 42698050, PMID 19216617, PMID 35939785, PMID 36408876, PMID 25495795, PMID 26931631, PMID 31697801, PMID 33719084, PMID 36848635, PMID 39091324, PMID 17687129, PMID 22149959, PMID 22212248, PMID 22765835, PMID 25273984, PMID 26157075, PMID 26679394, PMID 27002680, PMID 28691557, PMID 29224506, PMID 30157389, PMID 32293786, PMID 32744769, PMID 32915950, PMID 33269010, PMID 34788507, PMID 34922648, PMID 35857660, PMID 35879931, PMID 36796484, PMID 36884286, PMID 37341915, PMID 38237075, PMID 39341368, PMID 39642315, PMID 40099428, PMID 40188458, PMID 40197980, PMID 40347119, PMID 40986187, PMID 41637644, PMID 10529148, PMID 10792474, PMID 10960937, PMID 12828678, PMID 1347102, PMID 1374895
2016 (19), 2023 (19), 2009 (16), 2015 (13), 2017 (13), 2008 (12), 2014 (11), 2018 (10), 2025 (5), 2019 (4), 2005 (3), 1UG3HL165064-01 (1), 2004 (1), K23HL105785 (1), R01AI049508 (1)