157 completed, 27 recruiting, 27 terminated, 21 unknown. 57 Phase 3, 52 Phase 1, 38 Phase 2, 17 Not applicable, 15 Phase 4.
Follow Hemophilia B: new trials by email Literature Review of Hemophilia B trials Research Report on Hemophilia B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lentiviral FIX Gene Therapy YUVA-GT-F901 - Hemophilia B | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2027-06-01 | 2026-08-26 |
| Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy Multicomponent pain self-management programme - Hemophilic Arthropathy, Chronic Pain | Not applicable | Not yet recruiting | Investigación en Hemofilia y Fisioterapia | 70 | 2027-03-01 | 2026-10-06 |
| Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%) Joint Ultrasound (HEAD-US), Blood Sample for Coagulation Factor Measurement - Mild Hemophilia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 150 | 2027-02-01 | 2026-08-17 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Liver Biopsy Following Gene Therapy For Hemophilia Liver Biopsy - Hemophilia A, Hemophilia B | Not yet recruiting | St. Jude Children's Research Hospital | 8 | 2026-11-01 | 2026-10-22 | |
| A Study to Learn About the Study Medicine (Called Marstacimab) in People With Hemophilia A or B Marstacimab - Hemophilia | Not yet recruiting | Pfizer | 100 | 2026-10-05 | 2026-10-05 | |
| Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE) Aripiprazole (low-dose, 1mg), Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Christiana Franke | 138 | 2026-10-01 | 2026-07-20 |
| A Phase III Clinical Trial Evaluating SR604 Injection for Prophylactic Treatment in Patients With Hemophilia SR604 - Hemophilia A, Hemophilia A and B | Phase 3 | Not yet recruiting | Shanghai RAAS Blood Products Co., Ltd. | 90 | 2026-09-30 | 2026-10-15 |
| SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis Emicizumab, FEIBA, rFVIIa - Hemophilia A | Phase 3 | Recruiting | Emory University | 5 | 2026-09-01 | 2026-08-21 |
| Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock Anisodamine intravenous infusion - Septic Shock, Sepsis | Not applicable | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 20 | 2026-08-01 | 2026-06-18 |
| Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock Dexmedetomidine Intravenous Infusion - Septic Shock, Sepsis | Not applicable | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 20 | 2026-08-01 | 2026-06-18 |
| Comparison of 30-Second Sit-to-Stand Test Performance Between Individuals With Hemophilia and Healthy Peers Hemophilia A and B | Not yet recruiting | Bahçeşehir University | 58 | 2026-08-01 | 2026-07-31 | |
| Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery fresh frozen plasma, prothrombin complex concentrate - Cardiac Valve Disease | Phase 4 | Recruiting | Konkuk University Medical Center | 100 | 2026-03-27 | 2026-06-17 |
| Validity and Reliability of the Two-minute Step Test in Hemophilia Hemophilia, Step | Completed | Hasan Kalyoncu University | 31 | 2026-02-25 | 2026-09-23 | |
| Phase 3, Open-label, Single-dose Study of CSL222 in Adolescent Male Subjects (≥ 12 to < 18 Years of Age) With Severe or Moderately Severe Hemophilia B CSL222 (Adeno-associated viral vector serotype 5 [AAV5]-hFIXco-Padua) - Hemophilia B | Phase 3 | Recruiting | CSL Behring | 20 | 2025-07-28 | 2026-10-20 |
| Synovial Proliferation on Routine Ultrasound: Active or Inactive? Ultrasound imaging - Haemophilia, Hemophilia A | Recruiting | Van Creveldkliniek | 46 | 2025-06-01 | 2026-05-05 | |
| Post-marketing Surveillance (Special Use-results Surveillance) on Treatment With Alhemo Concizumab - Haemophilia A, Haemophilia B | Enrolling by invitation | Novo Nordisk A/S | 30 | 2025-05-02 | 2026-06-15 | |
| Patient Interview Study to Explore the Impact of Gene Therapy in Hemophilia A & B Hemophilia A, Hemophilia B | Withdrawn | Pfizer | 2025-03-17 | 2025-08-29 | ||
| BeCoMe-9: A Clinical Study of BE-101 for the Treatment of Adults With Moderately Severe or Severe Hemophilia B BE-101 - Hemophilia B, Hemophilia B, Moderately Severe or Severe | Phase 1 / Phase 2 | Terminated | Be Biopharma | 5 | 2024-12-04 | 2026-06-15 |
| An Open-Label, Comparative Study of the Efficacy, Safety and Pharmacodynamics of Single Dose of ANB-002 in Patients With Hemophilia B ANB-002 - Hemophilia B | Phase 3 | Recruiting | Biocad | 24 | 2024-11-07 | 2025-11-18 |
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Hemophilia A (137) · Blood Coagulation Disorders (11) · Hematologic Diseases (11) · Hemorrhage (9) · Coagulation Protein Disorders (8) · Genetic Diseases, Inborn (7) · Hemorrhagic Disorders (7) · Thrombosis (7) · Anemia, Sickle Cell (6) · Hemostatic Disorders (6) · von Willebrand Diseases (6) · Joint Diseases (5) · Blood Coagulation Disorders, Inherited (4) · Cystic Fibrosis (4)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (260) · Hemic and Lymphatic Diseases (260) · Genetic Diseases, X-Linked (257) · Blood Coagulation Disorders, Inherited (256) · Genetic Diseases, Inborn (253) · Hemorrhagic Disorders (253) · Coagulation Protein Disorders (252) · Blood Coagulation Disorders (249) · Hematologic Diseases (249) · Pathological Conditions, Signs and Symptoms (27) · Pathologic Processes (22) · Cardiovascular Diseases (16) · Musculoskeletal Diseases (12) · Vascular Diseases (12) · Immune System Diseases (9)
Factor IX (31) · factor IX Fc fusion protein (9) · nonacog beta pegol (9) · prothrombin complex concentrates (6) · Blood Specimen Collection (5) · albutrepenonacog alfa (5) · Factor VII (4) · IB1001 (4) · marstacimab (4) · High-Energy Shock Waves (3) · Protein C (3) · factor IX, factor VII, factor X, prothrombin drug combination (3) · fitusiran (3) · recombinant FVIIa (3) · Factor VIII (2)
Novo Nordisk A/S (36) · Pfizer (21) · Baxalta now part of Shire (17) · CSL Behring (17) · Wyeth is now a wholly owned subsidiary of Pfizer (11) · Institute of Hematology & Blood Diseases Hospital, China (7) · Swedish Orphan Biovitrum (7) · American Thrombosis and Hemostasis Network (5) · ApcinteX Ltd (5) · Bayer (5) · Bio Products Laboratory (5) · Bioverativ Therapeutics Inc. (5) · Assistance Publique - Hôpitaux de Paris (3) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (3) · Genzyme, a Sanofi Company (3)
United States (102) · United Kingdom (69) · France (54) · Germany (52) · Italy (44) · Spain (44) · Canada (41) · Japan (33) · Turkey (Türkiye) (31) · China (29) · Australia (27) · Poland (25) · Russia (24) · South Africa (24) · Bulgaria (23)
Lei Zhang, MD (5) · Ulrike Reiss, MD (3)
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