27 completed, 8 terminated, 5 not yet recruiting, 3 recruiting. 25 Not applicable, 4 Phase 4, 3 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 25 | Completed 14, Terminated 5, Not yet recruiting 4, Recruiting 1, Unknown 1 |
| Phase 4 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 1 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Knee Pain: new trials by email Literature Review of Knee Pain trials Research Report on Knee Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| US-Guided Saphenous Block in Knee OA Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program - Knee Osteoarthritis, Osteoarthritis, Knee | Not applicable | Not yet recruiting | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | 60 | 2026-10-02 | 2026-10-09 |
| A Clinical Trial to Investigate the Efficacy and Safety of a Plant-based Cetylated Fatty Acids (CFA) on Knee Pain and Stiffness in Healthy Adults With Persistent Knee Pain Plant-derived cetylated fatty acids (CFA), Placebo - Joint Health, Mobility | Not applicable | Not yet recruiting | Everwell Health | 80 | 2026-09-01 | 2026-09-28 |
| Mikhled Knee Exercise Program With and Without Stecco Fascial Manipulation Effect in Patellofemoral Pain Syndrome Mikhled Knee Exercises with Stecco Fascial Manipulation, Mikhled Knee Exercise Program (MKEP) - Knee Pain, Patellofemoral Pain Syndrome | Not applicable | Not yet recruiting | Riphah International University | 58 | 2026-07-01 | 2026-07-21 |
| Validity and Reliability of Video-Based Functional Physiotherapy Assessment of Subacute Knee Injuries Physiotherapy digital assessment, Physiotherapy assessment - only functional tests - Knee Pain | Not applicable | Recruiting | Vastra Gotaland Region | 138 | 2026-01-26 | 2026-08-26 |
| Mobile App-Assisted Home Exercise for Musculoskeletal Disorders Mobile App-Assisted Home Exercise with Standard Physiotherapy, Traditional Home Exercise with Standard Physiotherapy - Musculoskeletal Disorders, Low Back Pain | Not applicable | Completed | National Yang Ming Chiao Tung University | 30 | 2026-01-15 | 2026-10-15 |
| Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-12-10 | 2025-11-20 | |
| Genicular Nerve Block for Knee Pain in the ED Genicular nerve block with bupivacaine and corticosteroids, Standard of Care - Knee Pain | Not applicable | Completed | University of Pennsylvania | 8 | 2025-08-06 | 2026-10-02 |
| Effects of Short Foot Exercise on Knee Pain, Muscle Tone, Balance, and Quality of Life in Flexible Flatfoot Patients Short Foot Exercise, Conventional Physical Therapy - Flexible Flatfoot, Knee Pain | Not applicable | Not yet recruiting | Sahmyook University | 44 | 2025-03-02 | 2025-03-06 |
| FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis Patellofemoral Osteoarthritis, Knee Osteoarthritis | Recruiting | University of California, San Francisco | 50 | 2025-02-19 | 2026-06-04 | |
| Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty Embozene Color-Advanced Microspheres. - Knee Pain | Not applicable | Terminated | NYU Langone Health | 2 | 2024-05-24 | 2025-08-07 |
| Biopsychosocial Factors in Resistance Exercise in Individuals with Knee Pain Leg Extension Exercise - Knee Pain | Not applicable | Completed | University of Central Florida | 57 | 2024-01-16 | 2024-09-26 |
| Clinical Outcomes of Intraarticular Platelet-Rich Plasma Injection in Knee Osteoarthritis Platelet-Rich Plasma (PRP) - Knee Osteoarthritis, Osteoarthritis (OA) | Not applicable | Completed | KIST Medical and Teaching Hospital | 59 | 2022-11-05 | 2026-09-18 |
| Cryoneurolysis for Knee and Shoulder Pain in an Inpatient Setting Cryoneurolysis - Shoulder Pain, Knee Pain | Unknown | Vancouver Island Health Authority | 25 | 2022-10-10 | 2024-06-14 | |
| TENS in Post-operative Total Knee Arthroplasty Recovery and Intra-venous Analgesics Requirement Routine Physical Therapy and Intra-venous analgesic regimen, Transcutaneous Electrical Nerve Stimulation along with Routine Physical Therapy and Intra-venous analgesic regimen - Total Knee Arthoplasty, Knee Pain | Not applicable | Completed | University of Lahore | 60 | 2022-07-13 | 2023-04-07 |
| A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain Arch supports - Plantar Fasciitis of Both Feet, Metatarsalgia | Completed | Massachusetts General Hospital | 43 | 2022-06-13 | 2025-08-08 | |
| A Reliability and Validity Study of Urdu Version of Knee Outcome Survey-Activities of Daily Living Scale Knee Pain | Completed | Riphah International University | 150 | 2021-05-30 | 2022-07-06 | |
| ROSA Total Knee Post Market Study EMEA Device: Persona Total Knee, Device: NexGen Total Knee, Device: Vanguard Total Knee - Knee Pain, Chronic Osteoarthritis | Not applicable | Completed | Zimmer Biomet | 252 | 2020-12-15 | 2026-05-12 |
| ROSA Robot Used in Total Knee Replacement Post Market Study PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee - Knee Pain, Chronic Osteoarthritis | Not applicable | Completed | Zimmer Biomet | 181 | 2020-05-01 | 2024-05-03 |
| Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis Methotrexate, Placebo - Knee Osteoarthritis, Effusion Synovial | Not applicable | Completed | Zhujiang Hospital | 215 | 2019-07-18 | 2024-02-28 |
| The Effects of Transcutaneous Electrical Nerve Stimulation on People With Knee Osteoarthritis (OA) and or Chronic Pain electrical stimulation, Sham - Knee Pain | Not applicable | Unknown | Omron Healthcare Co., Ltd. | 30 | 2019-07-15 | 2020-03-16 |
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Osteoarthritis, Knee (13) · Osteoarthritis (6) · Pain (5) · Low Back Pain (4) · Arthritis, Rheumatoid (3) · Genu Valgum (3) · Patellofemoral Pain Syndrome (3) · Shoulder Pain (3) · Arthralgia (2) · Chronic Pain (2) · Knee Injuries (2) · Motor Activity (2) · Neck Pain (2) · Agnosia (1) · Blindness, Cortical (1)
Joint Diseases (27) · Musculoskeletal Diseases (27) · Arthritis (19) · Rheumatic Diseases (19) · Pathological Conditions, Signs and Symptoms (17) · Signs and Symptoms (16) · Neurologic Manifestations (15) · Osteoarthritis (10) · Pain (8) · Nervous System Diseases (6) · Back Pain (4) · Bone Diseases (4) · Pathologic Processes (4) · Skin and Connective Tissue Diseases (4) · Arthralgia (3)
Adrenal Cortex Hormones (3) · Bupivacaine (2) · Acupuncture Therapy (1) · Blood Specimen Collection (1) · Bonolive (1) · Botulinum Toxins, Type A (1) · Cognitive Behavioral Therapy (1) · Control Groups (1) · Electric Stimulation (1) · Foot Orthoses (1) · Fracture Fixation, Intramedullary (1) · High-Energy Shock Waves (1) · Massage (1) · Methotrexate (1) · Muscle Stretching Exercises (1)
Zimmer Biomet (3) · Aalborg University (2) · Riphah International University (2) · Alexandria University (1) · Brock Foster (1) · Chengdu University of Traditional Chinese Medicine (1) · China Medical University Hospital (1) · Dr. S R Thanthulage (1) · Everwell Health (1) · Gaziler Physical Medicine and Rehabilitation Education and Research Hospital (1) · Henning Bliddal (1) · Hilal Yeşil (1) · Jaseng Hospital of Korean Medicine (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · KIST Medical and Teaching Hospital (1)
United States (16) · Canada (3) · Denmark (3) · Pakistan (3) · Turkey (Türkiye) (3) · Belgium (2) · Israel (2) · South Korea (2) · Taiwan (2) · Australia (1) · China (1) · Croatia (1) · Egypt (1) · Germany (1) · Italy (1)
Abigail Wilson (1) · Adam S Landsman, DPM, PhD (1) · Alessandro Andreucci, PhD (1) · Ann M. Rogers, M.D. (1) · Bedros Taslakian, MD (1) · Changhai Ding, MD (1) · Charles Jaggard (1) · Christopher Ingersoll, PhD (1) · Daniel I Sessler, M.D. (1) · David Crowley (1) · Emilie Rohmer (1) · Eugene Y Roh, MD (1) · Filiz Can, Prof. (1) · Gary S Kitay, MD (1) · Gregory V. Hickman, MD (1)
PMID 19433134, PMID 19997004, PMID 20810509, PMID 24167727, PMID 25818278, PMID 25985806, PMID 26850111, PMID 28631699, PMID 28768617, PMID 28928789, PMID 31142518, PMID 32318673, PMID 32399187, PMID 32938470, PMID 34239634, PMID 34924251, PMID 37070890, PMID 39757775, PMID 40455462, PMID 42177223
K24AR072133 (1), R21AG041942 (1)