11 unknown, 5 completed, 3 not yet recruiting, 3 recruiting. 4 Not applicable, 3 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 3 | Not yet recruiting 2, Terminated 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Intrahepatic Cholestasis of Pregnancy: new trials by email Literature Review of Intrahepatic Cholestasis of Pregnancy trials Research Report on Intrahepatic Cholestasis of Pregnancy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MRX-901: An Open-label Study to Assess Safety and Tolerability of Maralixibat in Participants With Intrahepatic Cholestasis of Pregnancy (ICP) Maralixibat - Intrahepatic Cholestasis of Pregnancy | Phase 2 | Not yet recruiting | Mirum Pharmaceuticals, Inc. | 15 | 2027-01-15 | 2026-09-16 |
| The Effect of a Single Intravenous Injection of Esketamine During Cesarean Section on Postoperative Pruritus in Patients With Intrahepatic Cholestasis of Pregnancy Normal Saline (0.9% NaCl), Esketamine 0.3mg/kg - Intrahepatic Cholestasis of Pregnancy | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 160 | 2026-05-05 | 2026-05-01 |
| Maralixibat for Intrahepatic Cholestasis of Pregnancy Maralixibat - Intrahepatic Cholestasis of Pregnancy | Phase 2 | Not yet recruiting | Imperial College London | 28 | 2026-04-01 | 2026-02-05 |
| Impact of Intrahepatic Cholestasis of Pregnancy on Neonatal Respiratory Outcomes Intrahepatic Cholestasis of Pregnancy, Respiratory Distress Syndrome, Newborn | Enrolling by invitation | Carol Davila University of Medicine and Pharmacy | 120 | 2024-10-28 | 2026-02-18 | |
| Serum Bile Acid Profiles in Patients With Intrahepatic Cholestasis of Pregnancy Intrahepatic Cholestasis of Pregnancy | Recruiting | Jena University Hospital | 74 | 2024-07-01 | 2026-02-23 | |
| Unraveling the Pathogenesis of Pruritus in Intrahepatic Cholestasis of Pregnancy Intrahepatic Cholestasis of Pregnancy | Unknown | Peking University | 600 | 2024-04-20 | 2024-04-16 | |
| Investigation of the Pruritogens of Liver-related Diseases Cholestasis, Intrahepatic Cholestasis of Pregnancy | Unknown | Peking University | 200 | 2024-04-20 | 2024-04-16 | |
| Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population Intrahepatic Cholestasis of Pregnancy, Genetic Mutation | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 150 | 2022-12-08 | 2026-05-18 | |
| Different Effects of Delayed Clamping on Neonatal Bilirubin Levels Between Pregnant Women With Intrahepatic Cholestasis of Pregnancy and Normal Pregnant Women clamp time of umbilical - Intrahepatic Cholestasis of Pregnancy | Not applicable | Unknown | Second Affiliated Hospital of Wenzhou Medical University | 200 | 2022-12-01 | 2023-02-22 |
| Diet in Twin Pregnancy: the Wellness of Mother and Babies. Specific Diet - Twin Pregnancy, Antepartum Condition or Complication, Gestational Diabetes | Not applicable | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 200 | 2022-10-10 | 2023-03-20 |
| Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation Cholestasis of Pregnancy | Recruiting | University Hospital, Brest | 322 | 2022-06-21 | 2024-10-16 | |
| Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases Thermal imaging, Echocardiogram, ECG - Diabetes Mellitus, Intrahepatic Cholestasis of Pregnancy | Unknown | Guy's and St Thomas' NHS Foundation Trust | 80 | 2021-06-01 | 2021-05-18 | |
| A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA) Volixibat, Placebo - Intrahepatic Cholestasis of Pregnancy | Phase 2 | Terminated | Mirum Pharmaceuticals, Inc. | 4 | 2021-01-04 | 2024-08-06 |
| Liver Disease in Pregnancy Pregnancy Disease, Cirrhosis, Liver | Unknown | King's College Hospital NHS Trust | 100 | 2019-05-09 | 2020-03-27 | |
| Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives ursofalk - Cholestasis of Pregnancy | Unknown | Alexandra Hospital, Athens, Greece | 50 | 2018-01-01 | 2021-09-02 | |
| The Microbiome Composition in Women With Recurring Intrahepatic Cholestasis of Pregnancy (ICP) Exploratory - Intrahepatic Cholestasis of Pregnancy | Completed | MetaboGen AB | 105 | 2017-02-14 | 2021-12-09 | |
| Serum Autotaxin Levels in Cholestasis of Pregnancy Intrahepatic Cholestasis of Pregnancy | Unknown | Sisli Hamidiye Etfal Training and Research Hospital | 50 | 2015-06-01 | 2016-04-20 | |
| Bile Acid Effects in Fetal Arrhythmia Study Monica AN24 - Cholestasis of Pregnancy, Intrahepatic Cholestasis of Pregnancy | Unknown | Guy's and St Thomas' NHS Foundation Trust | 400 | 2015-02-27 | 2019-08-02 | |
| P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Intrahepatic Cholestasis of Pregnancy, Arrhythmia | Unknown | Zekai Tahir Burak Women's Health Research and Education Hospital | 90 | 2013-07-01 | 2014-03-18 | |
| Il-17 Levels in Intrahepatic Cholestasis of Pregnancy Intrahepatic Cholestasis of Pregnancy | Unknown | Zekai Tahir Burak Women's Health Research and Education Hospital | 30 | 2013-07-01 | 2014-03-18 |
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Cholestasis (8) · Pruritus (6) · Diabetes, Gestational (3) · Cholestasis, Intrahepatic (2) · Acute fatty liver of pregnancy (1) · Arrhythmias, Cardiac (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Disease (1) · Feeding Behavior (1) · HELLP Syndrome (1) · Hypertension, Pregnancy-Induced (1) · Inflammation (1)
Pathological Conditions, Signs and Symptoms (12) · Digestive System Diseases (11) · Bile Duct Diseases (10) · Biliary Tract Diseases (10) · Pathologic Processes (6) · Signs and Symptoms (6) · Skin Diseases (6) · Skin Manifestations (6) · Skin and Connective Tissue Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (5) · Pregnancy Complications (5) · Urogenital Diseases (5) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Liver Diseases (3)
Ursodeoxycholic Acid (2) · maralixibat (2) · Docosahexaenoic Acids (1) · Echocardiography (1) · Electrocardiography (1) · Esketamine (1) · Magnetic Resonance Imaging (1) · Saline Solution (1) · volixibat (1)
Guy's and St Thomas' NHS Foundation Trust (2) · Imperial College London (2) · Mirum Pharmaceuticals, Inc. (2) · Peking University (2) · Zekai Tahir Burak Women's Health Research and Education Hospital (2) · Alexandra Hospital, Athens, Greece (1) · Carol Davila University of Medicine and Pharmacy (1) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Icahn School of Medicine at Mount Sinai (1) · Jena University Hospital (1) · Karolinska Institutet (1) · King's College Hospital NHS Trust (1) · MetaboGen AB (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1)
China (5) · United Kingdom (5) · Turkey (Türkiye) (3) · France (2) · Italy (2) · Germany (1) · Greece (1) · India (1) · New Zealand (1) · Romania (1) · Sweden (1) · United States (1)
Yulong Li (2) · Catherine Williamson (1) · Catherine Williamson, MBChBMDFRCP (1) · Catherine Williamson, MD (1) · Francesco Azzaroli, Professor (1) · Giuseppe Mazzella, Professor (1) · Guolin Wang (1) · Hakan Erenel, MD,OBGYN (1) · Helena Strevens, MD, PhD (1) · Katherine Kohari, MD (1) · Madhumita Premkumar (1) · Michael Heneghan (1) · Tanja Groten, Prof. Dr. med. (1)