7 completed, 2 recruiting, 1 enrolling by invitation, 1 not yet recruiting. 5 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 4, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Idiopathic Normal Pressure Hydrocephalus (INPH): new trials by email Literature Review of Idiopathic Normal Pressure Hydrocephalus (INPH) trials Research Report on Idiopathic Normal Pressure Hydrocephalus (INPH)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study Brain Pulsatility, Idiopathic Normal Pressure Hydrocephalus (INPH) | Not yet recruiting | University Hospital, Tours | 110 | 2026-05-01 | 2026-04-30 | |
| Functional Outcomes After LumbOpenitoneal Shunt Placement UndeR Local Anesthesia for Patients With Idiopathic Normal preSsure Hydrocephalus (FLOURISH) Trial ventriculoperitoneal shunt surgery under general anesthesia, lumbar-peritoneal shunt procedure under local anesthesia - Idiopathic Normal Pressure Hydrocephalus (INPH) | Phase 4 | Withdrawn | Institute for Clinical Effectiveness, Japan | 2026-04-01 | 2026-08-21 | |
| Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG) Observational Data Collection - Freezing of Gait, Parkinson's Disease | Recruiting | Tianjin Huanhu Hospital | 700 | 2026-02-28 | 2026-03-10 | |
| Unsteady Gait in Older People May be a Common and Treatable Neurological Disease Associated With Increased Mortality Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic | Enrolling by invitation | Umeå University | 450 | 2025-09-01 | 2026-04-29 | |
| Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST) Endoscopic third ventriculostomy (ETV), Ventriculoperitoneal shunt (VPS) - Idiopathic Normal Pressure Hydrocephalus (INPH) | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 150 | 2025-01-17 | 2025-02-03 |
| The Pilot Study of Medical Device-Neuclare for Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH) Neuclare - Idiopathic Normal Pressure Hydrocephalus (iNPH) | Not applicable | Completed | Deepsonbio | 20 | 2024-07-22 | 2026-08-24 |
| Efficacy in iNPH Shunting (PENS) Trial programmable CSF shunt valve - Idiopathic Normal Pressure Hydrocephalus (INPH) | Not applicable | Completed | Johns Hopkins University | 99 | 2022-05-18 | 2026-08-27 |
| Acetazolamide Trial in Normal Pressure Hydrocephalus Acetazolamide, Placebo - Idiopathic Normal Pressure Hydrocephalus (INPH) | Phase 2 | Completed | Uppsala University Hospital | 50 | 2022-02-17 | 2026-05-06 |
| Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH) Ventriculoperitoneal shunt - Idiopathic Normal Pressure Hydrocephalus (INPH) | Completed | Oslo University Hospital | 276 | 2018-09-01 | 2026-09-08 | |
| A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial programmable CSF shunt valve - Idiopathic Normal Pressure Hydrocephalus (INPH) | Not applicable | Completed | Johns Hopkins University | 18 | 2018-05-21 | 2022-08-02 |
| Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases | Completed | Umeå University | 6500 | 2018-02-14 | 2022-01-24 | |
| Walking Pattern Characteristics in Normal Pressure Hydrocephalus Characterization of walking pattern characteristics in an ambulatory setting using wearable IMUs (ZurichMOVE sensors) - Idiopathic Normal Pressure Hydrocephalus (INPH) | Not applicable | Completed | University of Zurich | 60 | 2018-01-01 | 2024-04-26 |
Dementia (2) · Gait Disorders, Neurologic (2) · Hydrocephalus, Normal Pressure (2) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cognitive Dysfunction (1) · Frailty (1) · Mobility Limitation (1) · Parkinson Disease (1) · Parkinsonian Disorders (1)
Nervous System Diseases (5) · Brain Diseases (3) · Central Nervous System Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Hydrocephalus (2) · Mental Disorders (2) · Neurocognitive Disorders (2) · Neurologic Manifestations (2) · Basal Ganglia Diseases (1) · Cognition Disorders (1) · Movement Disorders (1) · Neurodegenerative Diseases (1) · Pathologic Processes (1) · Synucleinopathies (1)
Ventriculoperitoneal Shunt (2) · Acetazolamide (1) · Ventriculostomy (1)
Johns Hopkins University (2) · Umeå University (2) · Deepsonbio (1) · Institute for Clinical Effectiveness, Japan (1) · Oslo University Hospital (1) · Tianjin Huanhu Hospital (1) · University Hospital, Basel, Switzerland (1) · University Hospital, Tours (1) · University of Zurich (1) · Uppsala University Hospital (1)
Sweden (5) · Canada (2) · Switzerland (2) · United States (2) · China (1) · France (1) · Japan (1) · Norway (1) · South Korea (1)
Florian Marc Ebel, Dr. med. (1) · Jaeho Kim, M.D. Ph.D (1) · Jenny Larsson, MD, PhD (1) · Johan Virhammar, MD, PhD (1) · Mark Luciano, MD (1) · Mark Luciano, MD, PhD (1) · Peipei Liu, MD (1) · Richard Holubkov, PhD (1) · Takeshi Morimoto, MD, PhD, MPH (1)
PMID 36700738, PMID 40960253, PMID 41164400, PMID 42127932
2025 (1), U01NS122764 (1)