9 completed, 4 recruiting, 1 unknown, 1 withdrawn. 15 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 15 | Completed 9, Recruiting 4, Unknown 1, Withdrawn 1 |
Follow Hypoglycemia: new trials by email Literature Review of Hypoglycemia trials Research Report on Hypoglycemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of C-peptide on Hypoglycemic Counterregulation Saline, C-peptide - Hypoglycemia, Type 1 Diabetes | Early Phase 1 | Recruiting | University of Cincinnati | 38 | 2024-06-01 | 2026-02-17 |
| Micro Glucagon During Exercise in Type 1 Diabetes Micro-glucagon, Mini-glucagon - Type 1 Diabetes, Hypoglycemia | Early Phase 1 | Withdrawn | Insel Gruppe AG, University Hospital Bern | 2023-04-01 | 2023-09-01 | |
| Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I Triheptanoin - Glycogen Storage Disease Type I | Early Phase 1 | Completed | Areeg El-Gharbawy | 4 | 2020-10-16 | 2021-12-15 |
| Adrenergic System in Islet Transplantation Phentolamine, Propranolol, Placebo - Type1diabetes, Hypoglycemia | Early Phase 1 | Completed | University of Pennsylvania | 9 | 2017-01-20 | 2026-04-27 |
| Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes Insulin, Glucose, Potassium phosphate - Hypoglycemia | Early Phase 1 | Completed | University of Minnesota | 27 | 2016-11-01 | 2021-02-01 |
| The Effects of Bariatric Surgeries on Glucose Metabolism Exendin-(9-39), Atropine - Post Bariatric Surgery, Gastric Bypass | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2015-07-01 | 2025-09-09 |
| Differing Levels of Hypoglycemia Glucose clamp - Hypoglycemia | Early Phase 1 | Completed | University of Maryland, Baltimore | 32 | 2015-07-01 | 2026-11-06 |
| Preventing Hypoglycemia During Exercise With Proactive Snacking on Closed Loop Medtronic MiniMed Closed Loop (CL) System, Snacking - Type 1 Diabetes | Early Phase 1 | Completed | Yale University | 15 | 2015-01-01 | 2020-04-20 |
| 68Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of Nesidioblastosis 68Ga-NOTA-exendin-4 - Insulinoma, Nesidioblastosis | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 100 | 2014-02-01 | 2015-09-25 |
| GLP-1 and Hypoglycemia Glucagon-Like Peptide- 1 (GLP-1) infusion, Placebo Comparator: Saline Infusion - Type 2 Diabetes Mellitus | Early Phase 1 | Completed | University of Maryland, Baltimore | 28 | 2013-07-01 | 2026-11-06 |
| Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus Dehydroepiandrosterone, Placebo - Type 1 Diabetes | Early Phase 1 | Completed | University of Maryland, Baltimore | 50 | 2010-10-01 | 2019-09-12 |
| Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery Exendin-(9-39), Atropine, GLP-1 and GIP - Post Bariatricsurgery, Hypoglycemia | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 160 | 2009-10-01 | 2025-09-09 |
| Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia Insulin - Brain Neoplasms, Intracranial Aneurysm | Early Phase 1 | Completed | Northwestern University | 120 | 2009-10-01 | 2019-12-13 |
| Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4 Hyperinsulinemic Hypoglycemic Clamp - Type 2 Diabetes | Early Phase 1 | Completed | University of Maryland, Baltimore | 20 | 2007-05-01 | 2019-09-12 |
| Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass exendin-(9-39), exendin -(9-39) - Post-bariatric Surgery | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 80 | 2005-11-01 | 2025-09-09 |
Diabetes Mellitus, Type 1 (4) · Diabetes Mellitus, Type 2 (2) · Motor Activity (2) · Brain Neoplasms (1) · Glycogen Storage Disease Type I (1) · Insulin Resistance (1) · Insulinoma (1) · Intracranial Aneurysm (1) · Nesidioblastosis (1)
Glucose Metabolism Disorders (15) · Metabolic Diseases (15) · Nutritional and Metabolic Diseases (15) · Endocrine System Diseases (7) · Diabetes Mellitus (6) · Autoimmune Diseases (4) · Immune System Diseases (4) · Behavior (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Hyperinsulinism (2) · Neoplasms (2) · Neoplasms by Site (2) · Adenoma (1) · Adenoma, Islet Cell (1) · Aneurysm (1)
exendin (9-39) (3) · Atropine (2) · Glucagon-Like Peptide 1 (2) · Glucose (2) · Insulin (2) · Insulin, Regular, Human (2) · Sodium Chloride (2) · 68Ga-NOTA-exendin-4 (1) · C-Peptide (1) · Dehydroepiandrosterone (1) · Drug Delivery Systems (1) · Glucose Clamp Technique (1) · Phentolamine (1) · Propranolol (1) · Snacks (1)
University of Maryland, Baltimore (4) · The University of Texas Health Science Center at San Antonio (3) · Areeg El-Gharbawy (1) · Insel Gruppe AG, University Hospital Bern (1) · Northwestern University (1) · Peking Union Medical College Hospital (1) · University of Cincinnati (1) · University of Minnesota (1) · University of Pennsylvania (1) · Yale University (1)
United States (13) · China (1)
Marzieh Salehi, MD, MS (2) · Stephen N. Davis, MD (2) · Areeg El-Gharbawy, MD (1) · Christoph Stettler, MD (1) · Dhanesh Gupta, MD (1) · Fang Li, MD (1) · Jason Winnick, PhD (1) · Jennifer Sherr, MD, PhD (1) · Marzieh Salehi, MD,MS (1) · Michael R Rickels, MD., MS (1) · Silvia Mangia, PhD (1) · Stephen N Davis, MBBS (1)
PMID 20587723, PMID 24315990, PMID 25695946, PMID 37166980, PMID 41712301
R01DK069803 (1), R01DK091331 (1), R01DK105379 (1), T32DK063703 (1), ZIAEB000073 (1)