23 completed, 3 recruiting, 3 terminated, 1 active not recruiting. 19 Not applicable, 8 Phase 1, 3 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 14, Recruiting 2, Terminated 2, Active not recruiting 1 |
| Phase 1 | 8 | Completed 8 |
| Phase 4 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow Glucose Clamp Technique: new trials by email Literature Review of Glucose Clamp Technique trials Research Report on Glucose Clamp Technique
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Glucagon on Cerebral Glucose Metabolism in Healthy Humans Glucagon (part C), Glucose clamp (part C), Saline (part C) - Cerebral Glucose Metabolism | Not applicable | Active not recruiting | Nicolai Jacob Wewer Albrechtsen | 12 | 2025-03-18 | 2026-04-29 |
| The Glucose-Independent Effects of Exogenous Glucagon on Insulin Secretion and Cognitive Function in Healthy Subjects Glucagon Infusion, Glucose clamp - Glucose Metabolism, Insulin Secretion | Not applicable | Completed | Nicolai Jacob Wewer Albrechtsen | 15 | 2024-11-08 | 2026-04-29 |
| Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise Muscle Biopsy, Adipose Biopsy, Glucose Clamp - Obesity | Not applicable | Recruiting | AdventHealth Translational Research Institute | 70 | 2024-09-11 | 2026-03-27 |
| Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes Oral glucose tolerance test (OGTT), Hyperglycemic clamp test, Continuous glucose monitoring - Type1 Diabetes Mellitus | Not applicable | Recruiting | Universitair Ziekenhuis Brussel | 75 | 2023-08-09 | 2026-08-17 |
| A Trial Investigating the Pharmacodynamics of BC Combo THDB0207 Compared With Humalog® Mix25 and Simultaneous Injections of Humalog® and Lantus® in Healthy Chinese Volunteers Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Humalog® Mix25, Euglycemic clamp with Humalog® and Lantus® - Healthy | Phase 1 | Completed | Adocia | 27 | 2022-05-12 | 2023-10-12 |
| A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Lantus®, Euglycemic clamp with Humalog® - Type 1 Diabetes | Phase 1 | Completed | Adocia | 30 | 2022-05-12 | 2023-09-15 |
| A Trial Investigating the Dose Linearity and Safety of BC Combo THDB0207 in Subjects With Type 2 Diabetes Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Humalog® Mix25 - Type 2 Diabetes | Phase 1 | Completed | Adocia | 40 | 2022-05-12 | 2023-09-15 |
| Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion Somatostatin, Dextrose, Insulin - Healthy | Phase 4 | Withdrawn | Mayo Clinic | 2020-02-01 | 2022-09-09 | |
| Effect of Glucose on QTc Interval in Type 1 Diabetes Moxifloxacin, hyper-glycaemic clamp - Diabetes | Phase 1 | Completed | Richmond Research Institute | 24 | 2019-02-10 | 2021-05-05 |
| Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation Euglycaemic Clamp, Hyperinsulinaemic/Hypoglycaemic Clamp - Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2 | Not applicable | Completed | Medical University of Graz | 14 | 2018-02-12 | 2019-11-18 |
| Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes Hypoglycaemic clamp, Euglycaemic clamp - Diabetes Mellitus, Type II, Hypoglycemia | Not applicable | Completed | Bispebjerg Hospital | 28 | 2017-06-13 | 2020-01-28 |
| Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects Glucose clamp technique - Hypoglycemia, Diabetes Mellitus, Type 1 | Not applicable | Completed | University of Aarhus | 18 | 2017-02-23 | 2022-10-05 |
| Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2) Hyperinsulinemic, euglycemic clamp, 20% dextrose - Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2 | Phase 1 | Completed | Vanderbilt University | 33 | 2016-12-01 | 2019-08-01 |
| Differing Levels of Hypoglycemia Glucose clamp - Hypoglycemia | Early Phase 1 | Recruiting | University of Maryland, Baltimore | 32 | 2015-07-01 | 2025-11-10 |
| Adipose Tissue Imaging in Type 2 Diabetes 18F-FDG PET/CT, euglycemic clamp, hypoglycemic clamp - Diabetes Mellitus Type 2 | Not applicable | Completed | Radboud University Medical Center | 15 | 2014-11-01 | 2017-05-31 |
| PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes Pre-study dietary and exercise instruction., Screening examination and oral glucose tolerance test, Euglycemic clamp - Diabetes, Obesity | Not applicable | Terminated | Mayo Clinic | 26 | 2014-05-01 | 2016-05-12 |
| Metabolomic Analysis of Hepatic Insulin Resistance Hyperinsulinemic-euglycemic clamp - Type 2 Diabetes, Obesity | Not applicable | Completed | University of Minnesota | 4 | 2013-04-01 | 2017-04-20 |
| A Trial Investigating the Effect of Acute Hypoglycaemia on Cognitive Function and Brain Activation Patterns in Subjects With Type 1 Diabetes glucose clamp - Diabetes, Diabetes Mellitus, Type 1 | Phase 1 | Completed | Novo Nordisk A/S | 29 | 2013-01-14 | 2018-01-12 |
| A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes glucose clamp - Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | Novo Nordisk A/S | 26 | 2013-01-01 | 2017-01-23 |
| Tissue-Specific Metabolic Reprogramming in Diabetic Complications Euglycemic clamp (normal blood sugar clamp) for 4 hours, hyperglycemic clamp (elevated blood sugar to 300) for 4 hours - Type 1 Diabetes Mellitus | Not applicable | Completed | University of Michigan | 35 | 2012-05-01 | 2018-06-28 |
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Diabetes Mellitus, Type 2 (9) · Diabetes Mellitus (7) · Diabetes Mellitus, Type 1 (6) · Hypoglycemia (5) · Obesity (5) · Hyperglycemia (2) · Insulin Resistance (2) · Depression (1) · Depressive Disorder, Major (1) · Dyslipidemias (1) · Glucose Intolerance (1) · Maturity-Onset Diabetes of the Young, Type 2 (1) · Schizophrenia (1)
Vanderbilt University (7) · Adocia (3) · Mayo Clinic (2) · Nicolai Jacob Wewer Albrechtsen (2) · Novo Nordisk A/S (2) · University of Aarhus (2) · AdventHealth Translational Research Institute (1) · Albert Einstein College of Medicine (1) · Beth Israel Deaconess Medical Center (1) · Bispebjerg Hospital (1) · Central Institute of Mental Health, Mannheim (1) · Medical University of Graz (1) · Pfizer (1) · Radboud University Medical Center (1) · Richmond Research Institute (1)
United States (12) · Denmark (7) · Germany (4) · Austria (1) · Belgium (1) · Netherlands (1) · United Kingdom (1)
Nicolai J Wewer Albrecthsen, MD PhD (2) · Oliver Klein, MD (2) · Stephen N Davis, MD (2) · Stephen N. Davis, MD (2) · Adrian Vella, MD (1) · Bart Keymeulen (1) · Daniel Kopf, M.D. (1) · Harald Sourij (1) · Jorg Taubel, MD FFPM (1) · Justin M Gregory, MD (1) · Lauren Sparks, PhD (1) · Lawrence J. Mandarino, Ph.D. (1) · Lisa Chow, MD (1)
PMID 19488737, PMID 25173047, PMID 26407587, PMID 29188338, PMID 31092478, PMID 31367958, PMID 32295804, PMID 32927476, PMID 35417272, PMID 35596173, PMID 35596784, PMID 35724307
1DP3DK094292-01 (1), R01DK078646 (1), R01DK091748 (1)